Prospective Randomized Comparison of Safety and Efficacy of Nicardipine and Nitroprusside Drip for Control of Hypertension in the Neurosurgical Intensive Care Unit

Roitberg, Ben; Hardman, Julian; Urbaniak, Klaudia; Merchant, Amina; Mangubat, Erwin Zeta; Alaraj, Ali; Mlinarevich, Nada; Watson, Karriem S.; Ruland, Sean

doi:10.1227/01.neu.0000319634.02983.cb

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…Therefore, until the ruptured aneurysm is treated, systolic blood pressure can be carefully titrated below 160 mm Hg [7]. Possible agents that have been reported to achieve blood pressure control in patients with SAH in prospective [15] and retrospective [16] series include labetalol, nicardipine and nitroprusside, among others.…”

Section: Diagnosis and Workup At Admissionmentioning

confidence: 99%

Management of aneurysmal subarachnoid haemorrhage

Schattlo¹,

Fathi²,

Fandiño³

2014

Swiss Med Wkly

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Aneurysmal subarachnoid haemorrhage (aSAH) occurs as a result of rupture of an intracranial aneurysm and affects a younger population compared with ischaemic stroke or intracerebral haemorrhage. Although it makes up only about 5% of all cerebrovascular events, it accounts for over a quarter of the productive life-years lost to stroke. Its surgical and medical treatment represents a multidisciplinary effort. We herein provide an overview of current management options for aSAH.

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Section: Diagnosis and Workup At Admissionmentioning

confidence: 99%

Management of aneurysmal subarachnoid haemorrhage

Schattlo¹,

Fathi²,

Fandiño³

2014

Swiss Med Wkly

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Interventions for deliberately altering blood pressure in acute stroke

Geeganage

Bath

2014

Cochrane Database of Systematic Reviews

118

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There is insu icient evidence to say that lowering blood pressure saves lives or reduces disability in people with acute stroke. Immediately restarting blood pressure-lowering drugs taken before the stroke may increase disability. Conclusion: More research is needed to identify those people who are most likely to benefit from altering blood pressure in acute stroke, the time window in which the treatment is likely to be of benefit, what types of stroke are likely to respond favourably, and the environment in which such treatment may be best given in routine practice.

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Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke

Bath

Krishnan

Appleton

2017

Cochrane Database of Systematic Reviews

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Background Nitric oxide (NO) has multiple effects that may be beneficial in acute stroke, including lowering blood pressure, and promoting reperfusion and cytoprotection. Some forms of nitric oxide synthase inhibition (NOS-I) may also be beneficial. However, high concentrations of NO are likely to be toxic to brain tissue. This is an update of a Cochrane review first published in 1998, and last updated in 2002.

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Prospective Randomized Comparison of Safety and Efficacy of Nicardipine and Nitroprusside Drip for Control of Hypertension in the Neurosurgical Intensive Care Unit

Cited by 8 publications

References 12 publications

Management of aneurysmal subarachnoid haemorrhage

Management of aneurysmal subarachnoid haemorrhage

Interventions for deliberately altering blood pressure in acute stroke

Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke

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