Prospective, randomized, controlled, observer-blinded trial of combined infrared photocoagulation and micronized purified flavonoid fraction versus each alone for the treatment of hemorrhoidal disease

Dimitroulopoulos, Dimitrios; Tsamakidis, Klisthenis; Xinopoulos, Dimitrios; Karaïtianos, I; Fotopoulou, Aikaterini; Paraskevas, E.

doi:10.1016/j.clinthera.2005.06.016

Cited by 37 publications

(32 citation statements)

References 26 publications

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“…Dimitroulopoulos in a RCT reported 48.7% of postoperative pain; in Gupta's RCT 100% of patient complained pain (32,34). In contrast, Ahmad reported only 16% of pain rates (35).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, Ahmad reported only 16% of pain rates (35). Post-operative bleeding ranged from 44% in Dimitroulopoulos' to 15% in Gupta's RCTs (32,34). Two RCTs reported 13% of recurrence rates for bleeding in @ C I C E d i z i o n i I n t e r n a z i o n a l i I-II degrees in a mean follow-up period of three months (32,34).…”

Section: Discussionmentioning

confidence: 97%

“…Two RCTs reported 13% of recurrence rates for bleeding in I-II degrees in a mean follow-up period of three months (32,34). Recurrences after IRC treatment are shown in Table 7.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, Ahmad reported only 16% of pain rates (35). Post-operative bleeding ranged from 44% in Dimitroulopoulos' to 15% in Gupta's RCTs (32,34). We evaluated the effectiveness in bleeding and prolapses control for different degrees of hemorrhoids; results are shown in Table 5.…”

Section: Resultsmentioning

confidence: 99%

“…We evaluated the effectiveness in bleeding and prolapses control for different degrees of hemorrhoids; results are shown in Table 5. Only one RCT evaluated the percentages of improvement for different hemorrhoidal degrees reporting an improvement in 78%, 51% and 22% for I, II and III hemorrhoidal degrees respectively (32). However, two RCTs reported a subjective moderate improvement in 81% and 93% of patients with I and II degrees of hemorrhoids (24,35).…”

Section: Resultsmentioning

confidence: 99%

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The non-surgical management for hemorrhoidal disease. A systematic review

Cocorullo¹

2017

GHIR

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IntroductionRationale. The non-surgical treatments for hemorrhoids include rubber band ligation (RBL), injection sclerotherapy (IS), infrared coagulation (IRC), anal stretch, cryosurgery, laser hemorroidectomy. These treatments are usually performed in outpatient clinics without anesthesia, so reducing the costs related to hospital stay, operation-theatre and anesthesia; moreover, these techniques are time-saving and allow preserving patients' working days. These procedures have found a large use in patients suffering bleeding and prolapse caused by early hemorrhoidal stages that did not found an improvement with conservative therapy.Objectives. The aim of this review is to provide a framework to select the best procedure for different patients in order to minimize complications and to obtain the cure for this widespread social problem. Among the treatments RBL, IS and IRC are the most utilized and were analyzed. It was analyzed: 1) Does these procedures help? 2) What are the common harms? 3) What are the rare harms? 4) How many are the recurrences? MethodsThis systematic review was undertaken in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (2).Eligibility criteria. Studies on patient complaining of bleeding or prolapse due to hemorroidal disease managed with RBL, IS and IRC were collected. The hemorroidal degrees and the presence of bleeding or prolapses were analyzed. The well-defined treatment modality and the symptoms resolution as outcome measures were The non-surgical treatments for hemorrhoids are cost and time-saving techniques usually performed in patients suffering early hemorrhoidal disease. The most used are rubber band ligation (RBL), injection sclerotherapy (IS), and infrared coagulation (IRC

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“…Dimitroulopoulos in a RCT reported 48.7% of postoperative pain; in Gupta's RCT 100% of patient complained pain (32,34). In contrast, Ahmad reported only 16% of pain rates (35).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

“…Two RCTs reported 13% of recurrence rates for bleeding in I-II degrees in a mean follow-up period of three months (32,34). Recurrences after IRC treatment are shown in Table 7.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The non-surgical management for hemorrhoidal disease. A systematic review

Cocorullo¹

2017

GHIR

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Phlebotonics for haemorrhoids

Perera

Liolitsa

Iype

et al. 2012

Cochrane Database of Systematic Reviews

101

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The evidence suggests that there is a potential benefit in using phlebotonics in treating haemorrhoidal disease as well as a benefit in alleviating post-haemorrhoidectomy symptoms. Outcomes such as bleeding and overall symptom improvement show a statistically significant beneficial effect and there were few concerns regarding their overall safety from the evidence presented in the clinical trials.However methodological limitations were encountered. In order to enhance our conclusion further, more robust clinical trials which take into account these limitations will need to be performed in the future.

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Traditional Chinese medicine herbs for preventing bleeding from haemorrhoids

Gan

Wang

et al. 2007

Cochrane Database of Systematic Reviews

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Prospective, randomized, controlled, observer-blinded trial of combined infrared photocoagulation and micronized purified flavonoid fraction versus each alone for the treatment of hemorrhoidal disease

Cited by 37 publications

References 26 publications

The non-surgical management for hemorrhoidal disease. A systematic review

The non-surgical management for hemorrhoidal disease. A systematic review

Phlebotonics for haemorrhoids

Traditional Chinese medicine herbs for preventing bleeding from haemorrhoids

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