Prospective Randomized Controlled Study to Determine the Effect of Topical Application of Botulinum Toxin A for Crow's Feet After Treatment With Ablative Fractional CO2 Laser

Mahmoud, Bassel H.; Burnett, Christopher T.; Ozog, David M.

doi:10.1097/01.dss.0000452642.83894.ab

Cited by 39 publications

(28 citation statements)

References 12 publications

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“…BoNTA is typically injected into the subcutaneous or intramuscular compartments with potential associated pain, discomfort, erythema, bruising and risk of infection. Recent work suggests that topical application of BoNTA (in its current form) may not penetrate the stratum corneum to elicit clinically discernible endpoints compared with injected toxin [45]. A spilt face study was conducted on ten subjects involving CO 2 -AFXL of the face with application of topical BoNTA on one side and normal saline on the other side as a control [45].…”

Section: Cosmetic Applicationsmentioning

confidence: 99%

“…Recent work suggests that topical application of BoNTA (in its current form) may not penetrate the stratum corneum to elicit clinically discernible endpoints compared with injected toxin [45]. A spilt face study was conducted on ten subjects involving CO 2 -AFXL of the face with application of topical BoNTA on one side and normal saline on the other side as a control [45]. Compared with the control side, topical application of BoNTA resulted in significant reduction in the number of periorbital wrinkles at 1 week and 1 month following treatment.…”

Section: Cosmetic Applicationsmentioning

confidence: 99%

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Laser-assisted drug delivery in dermatology: from animal models to clinical practice

Ali

Al‐Niaimi

2015

Lasers Med Sci

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Topical medicaments are the mainstay of the dermatologists' therapeutic arsenal. Laser-assisted drug delivery enhances the ability of topically applied medicaments to penetrate the skin. We discuss the mechanisms of laser-assisted drug delivery and animal models that have informed clinical practice. We review clinical studies that have employed laser-assisted drug delivery for a range of indications to date including non-melanoma skin cancer, vitiligo, scarring, vaccination, local anaesthesia, analgesia, viral warts, infantile haemangiomas and cosmetic uses. Studies thus far suggest that laser pre-treatment improves transepidermal absorption of topical agents and allows for a much deeper penetration of drugs than is possible with topical medicaments alone. This may allow more efficacious action of current treatments, such that conventional duration of treatment can be shortened or lower concentrations of active agents be used, potentially obviating side effects of treatment. The prospect of using laser technologies to facilitate transdermal vaccination and as an adjunct for inflammatory dermatoses and cosmetic indications remains in its infancy. As larger trials are published, involving greater numbers of patients and utilising various laser and topical medicament parameters, we will enhance our understanding of this nascent modality of treatment delivery.

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Section: Cosmetic Applicationsmentioning

confidence: 99%

Section: Cosmetic Applicationsmentioning

confidence: 99%

Laser-assisted drug delivery in dermatology: from animal models to clinical practice

Ali

Al‐Niaimi

2015

Lasers Med Sci

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“…54 Two studies have used a fractional ablative laser to create microscopic columns in the epidermis and dermis with the expectation that this would permit molecules of ABO to reach the superficial orbicularis oculi in the lower dermis. 55,56 …”

Section: Aesthetic Developmentsmentioning

confidence: 99%

“…Although the combination treatment was successful, the investigators point out that the procedure is more complicated and more expensive than injections. 56 …”

Section: Aesthetic Developmentsmentioning

confidence: 99%

New Uses of AbobotulinumtoxinA in Aesthetics

Schlessinger¹,

Gilbert²,

Cohen³

et al. 2017

Aesthetic Surgery Journal

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BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. These may be achieved through use of combinations of BoNT-A with other aesthetic procedures, tailoring the dose of toxin to the patient’s muscle mass or by using novel injection and application techniques. Beyond amelioration of facial lines, encouraging results have been seen with the use of BoNT-A to improve the appearance of hypertrophic and keloid scars and even to prevent them. Studies have been conducted with scars in various parts of the body and further research is ongoing. Dermatological and other medical uses for BoNT-A are also active areas of research. Injections of BoNT-A have been shown to reduce signs and symptoms of acne, rosacea, and psoriasis, to reduce neuromuscular pain, and to bring about significant improvements in a number of rare diseases that are caused or exacerbated by hyperhidrosis. This paper reviews these new uses for BoNT-A, looking at the rationale for their use and discussing the results of published case studies and clinical trials. These areas have shown great promise to date, but more and larger clinical studies will be required before these treatments become a clinical reality. To this end details are also provided of clinical trials currently listed in the main clinical trials database to highlight research areas of particular interest.

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“…4 Many physicians combine aesthetic products and energy-emitting devices to achieve 3-dimensional facial rejuvenation and optimal aesthetic results [5][6][7][8][9][10][11][12][13][14] ; however, the safety of combining MFU-V with other aesthetic products has not been evaluated. Limited clinical data exist on combining MFU-V with injectable products or multiple treatment modalities.…”

mentioning

confidence: 99%

Combining Microfocused Ultrasound With Botulinum Toxin and Temporary and Semi-Permanent Dermal Fillers

Fabi

Goldman

Mills

et al. 2016

Dermatologic Surgery

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Prospective Randomized Controlled Study to Determine the Effect of Topical Application of Botulinum Toxin A for Crow's Feet After Treatment With Ablative Fractional CO2 Laser

Abstract: Topically, noninjectable form of BoNT A applied on the surface of the skin after ablative fractional CO2 laser is effective in the treatment of lateral periorbital wrinkles.

Cited by 39 publications

References 12 publications

Laser-assisted drug delivery in dermatology: from animal models to clinical practice

Laser-assisted drug delivery in dermatology: from animal models to clinical practice

New Uses of AbobotulinumtoxinA in Aesthetics

Combining Microfocused Ultrasound With Botulinum Toxin and Temporary and Semi-Permanent Dermal Fillers

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