Prospective Randomized Controlled Trial Comparing 1- Versus 7-Day Manipulation Following Collagenase Injection for Dupuytren Contracture

Mickelson, Dayne; Noland, Shelley S.; Watt, Andrew; Kollitz, Kathleen M.; Vedder, Nicholas B.; Huang, Jerry I.

doi:10.1016/j.jhsa.2014.07.010

Cited by 42 publications

(49 citation statements)

References 18 publications

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“…or equal clinical improvement for the MCP joint compared with the PIP joint. 2,20,24,26,30 the Michigan hand questionnaire (MHQ). 33,34 Only three studies recorded PROMs, but none used the same measures and two did not include post-treatment scores.…”

Section: Resultsmentioning

confidence: 99%

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Dupuytren’s disease and collagenase: evidence for a paradigm shift in management

Paynter¹,

Tobin²,

Rozen³

et al. 2018

Australas J Plast Surg

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Introduction: Dupuytren’s disease (DD) is a common disease which leads to significant functional impairment of the hand. The recent introduction of Collagenase Clostridium Histolyticum (CCH) as a therapeutic option has changed the approach to disease management. Currently no management paradigm exists for treating Dupuytren’s disease within Australia. Methods: Databases were searched for Dupuytren’s disease patients receiving CCH. PRISMA guidelines were used to screen predefined classification of effectiveness, safety and recurrence of CCH. Results: In this review, 18 studies were included and analysed to evaluate the effectiveness, safety and recurrence of CCH. Conclusion: CCH has the potential as a non-surgical therapeutic option to expand the management paradigm for DD. This may minimise treatment time, cost and improve the public health care sector’s treatment of DD.

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Section: Resultsmentioning

confidence: 99%

“…18,24 Furthermore, three studies injected over three locations in the fibrous cord. 19,21,30 The measurement protocol for assessing contracture degree was scarce within the literature. Only five studies recorded their goniometer and goniometer user method.…”

Section: Serious Adverse Effectsmentioning

confidence: 99%

Dupuytren’s disease and collagenase: evidence for a paradigm shift in management

Paynter¹,

Tobin²,

Rozen³

et al. 2018

Australas J Plast Surg

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“…9 Warwick 38 performed a series in which results regarding "unusual" cords (natatory, Y-shaped or crow-foot cords) were specified in the same way as Verheyden. 39 Several studies [40][41][42] assessed the impact with respect to the extension time following consistent administration of treatment.…”

Section: Results Of the Clinical Studiesmentioning

confidence: 99%

“…The extension time varied among the studies, ranging from 24 hours (predominantly) up to 7 days in a clinical trial by Mickelson. 40 The systematic implementation of a physiotherapy protocol after CCH treatment is another controversial point regarding the outcomes. Thirteen articles indicate that patients were systematically referred to an established physiotherapy protocol or that monitoring was performed by specialist physiotherapists, 20,25,29,32,34,35,40,41,44,48,[51][52][53] four specify that patients did not receive physical therapy, 6,22,49,54 two have indicated it only if necessary, 46,55 and the rest did not indicate whether or not a physiotherapy protocol was included in the treatment protocol.…”

Section: Results Of the Clinical Studiesmentioning

confidence: 99%

“…56 The bibliography is variable in this regard. Twenty-seven articles refer to the systematic use of this device, 6,14,15,17,20,22,25,26,30,33,35,36,[38][39][40][41]44,[46][47][48][49]51,54,[57][58][59][60] and a multicenter study reports that only one of the centers used it without performing a statistical analysis of what this measurement could indicate. 61…”

Section: Results Of the Clinical Studiesmentioning

confidence: 99%

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Efficacy of Collagenase Clostridium Histolyticum for Dupuytren Disease: A Systematic Review

Sanjuán-Cerveró¹,

Vázquez-Ferreiro

Herrero

et al. 2017

Rev Iberoam Cir Mano

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Introduction Collagenase Clostridium Histolyticum (CCH) has become a therapeutic alternative for Dupuytren disease. However, its efficacy in the medium to long term is unknown. The objective of our study is to carry out a systematic review of the studies conducted on the subject. Material and Methods Systematic bibliographic search. Analysis depending on the time of progression, looking into 2 groups with the follow-up cut-off point of 1 year. Analysis of the number of patients who reached the primary endpoint, of the mean correction in degrees, and of the proportional correction of each joint.

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Cost-effectiveness of Recurrent Dupuytren Contracture Treatment

et al. 2020

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IMPORTANCE Owing to its tendency to recur, Dupuytren contracture often requires multiple treatments, which places additional economic burden on health care. The likelihood of contracture recurrence varies not only with treatment but also with disease characteristics, such as contracture severity and location, but prior cost-effectiveness analyses of Dupuytren contracture treatments have not considered these patient-specific disease characteristics. OBJECTIVE To identify the most cost-effective treatment regimen for patients with recurrent Dupuytren contracture. DESIGN, SETTING, AND PARTICIPANTS This economic evaluation was conducted with statetransition microsimulation modeling using data from published studies and Medicare. A simulated cohort of 10 000 individuals with Dupuytren contracture was created. Patients could transition yearly between the following health states: symptom-free, symptomatic, and death. Available treatments were collagenase clostridium histolyticum injection, percutaneous needle aponeurotomy (PNA), and limited fasciectomy (LF); individuals randomly chose any treatment when symptomatic. Patients were limited to 3 rounds of treatment for a contracture affecting 1 joint, totaling 27 unique combinations. If the contracture recurred after 3 treatments, patients lived with the disease for the remainder of life.

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Prospective Randomized Controlled Trial Comparing 1- Versus 7-Day Manipulation Following Collagenase Injection for Dupuytren Contracture

Cited by 42 publications

References 18 publications

Dupuytren’s disease and collagenase: evidence for a paradigm shift in management

Dupuytren’s disease and collagenase: evidence for a paradigm shift in management

Efficacy of Collagenase Clostridium Histolyticum for Dupuytren Disease: A Systematic Review

Cost-effectiveness of Recurrent Dupuytren Contracture Treatment

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