1998
DOI: 10.1002/hep.510270112
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Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma

Abstract: To assess whether ultrasound-guided percutaneous acetic acid injection is superior to percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC), 60 patients with one to four HCCs smaller than 3 cm were entered onto a randomized controlled trial. Thirty-one and 29 patients, respectively, were treated by percutaneous acetic acid injection using 50% acetic acid or by percutaneous ethanol injection using absolute ethanol. There were no significant differences in age, sex ratio, Child-… Show more

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Cited by 220 publications
(152 citation statements)
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“…However, up to 30% of the tumor cells could be transduced by this technique, which would be sufficient for effective gene therapy using suicide genes exhibiting a strong bystander effect 14 or using immunomodulatory genes. 15,16,18,19 As the technique of ultrasoundguided injection of ethanol or acetic acid into intrahepatic tumors 42 is routinely used in clinical practice, direct injection into HCCs might become a feasible route of vector administration for future gene therapeutic approaches. However, despite the high transduction efficiency in the tumor tissue, we observed transduced hepatocytes scattered throughout the liver parenchyma, which were most likely infected by recirculating adenovirus vectors having being drained into the circulation from the injected tumors.…”
Section: Discussionmentioning
confidence: 99%
“…However, up to 30% of the tumor cells could be transduced by this technique, which would be sufficient for effective gene therapy using suicide genes exhibiting a strong bystander effect 14 or using immunomodulatory genes. 15,16,18,19 As the technique of ultrasoundguided injection of ethanol or acetic acid into intrahepatic tumors 42 is routinely used in clinical practice, direct injection into HCCs might become a feasible route of vector administration for future gene therapeutic approaches. However, despite the high transduction efficiency in the tumor tissue, we observed transduced hepatocytes scattered throughout the liver parenchyma, which were most likely infected by recirculating adenovirus vectors having being drained into the circulation from the injected tumors.…”
Section: Discussionmentioning
confidence: 99%
“…The remaining 47 studies were excluded, either because they compared 2 active antitumoral treatments in 35 cases (involving percutaneous treatments [5], [22][23][24][25][26] …”
Section: Selection Of Trialsmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] For patients who undergo tumor resection, recurrence rates are about 40% to 60% at 2 years and 80% at 5 years. 3 Liver transplantation is associated with a moderate risk for recurrence, but this strategy is confined to very few patients.…”
mentioning
confidence: 99%