Prospective randomized controlled trial to compare 3‐dimensional conformal radiotherapy to intensity‐modulated radiotherapy in head and neck squamous cell carcinoma: Long‐term results

Abstract

IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1481-E1487, 2016.

Radiotherapeutic management of cervical lymph node metastases from an unknown primary site – experiences from a large cohort treated with modern radiation techniques

“…Bilateral radiotherapy, especially when combined with radiotherapy to large mucosal areas was reported to provoke high toxicity rates for CCUP patients, but these patients were treated with older 2-or 3-dimensional techniques [33]. Our study focused on patients that were treated with IGRT and IMRT, as these newer techniques have demonstrated superior toxicity profiles for head-and-neck treatments in various analyses [2,22,23,[34][35][36]. Hence, in our cohort, only 5.2% of patients exhibited acute grade 3 radiation dermatitis and 22.4% of patients had acute grade ≥ 3 mucositis with no reported grade 5 toxicities, demonstrating an acceptable tolerance for extended radiotherapy.…”

Rescue Effects and Underlying Mechanisms of IntraglandShhGene Delivery on Irradiation-Induced Hyposalivation

“…4 Novel intensity-modulated radiotherapy significantly decreased irradiation dose to salivary glands and the incidence of xerostomia, but about 20% of patients treated with intensitymodulated radiotherapy still have long-term xerostomia and related weight loss. 5 Hyposalivation exacerbates dental caries and periodontal disease and causes problems of mastication, swallowing, sleep, and speech, a burning sensation of the mouth, and dysgeusia, which severely impair the quality of life of patients. The irreversible hyposalivation is caused by the loss or impairment of saliva-producing acinar cells and their replacement by connective tissue and fibrosis, which has been attributed to the loss of functional glandular stem/progenitor cells 6 and the impairment of parasympathetic innervation 7 and microvessels.…”

Maintenance of Head and Neck Tumor On-Chip: Gateway to Personalized Treatment?

“…A significant proportion of patients present with regional nodal involvement (40%) and a further 10% present with the additional complication of distant metastasis [4]. Chemoradiation is the predominant primary treatment, but despite multiple advances over recent years, such as the introduction of intensity-modulated radiotherapy [5,6], treatment resistance is a persistent problem, contributing to the low overall 5-year survival figures of 40–60% for patients treated with radiotherapy or chemoradiotherapy [7]. …”