Prospective randomized, double-blinded, placebo-controlled trial of preoperative rofecoxib for pain relief in uterine curettage

Poomtavorn, Yenrudee; Phupong, Vorapong

doi:10.1007/s00404-005-0041-y

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…However, the combination of intrauterine anesthesia and naproxen sodium has been shown to have a promising effect on pain reduction. In addition to the study by Poomtavorn and Phupong [22], this study also reveals that there are different sources of uterine pain. We used a different type of NSAID administered rectally and were also unable to demonstrate a pain-reducing effect.…”

Section: Discussionmentioning

confidence: 99%

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Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

Telli

Aydın²,

Öge

et al. 2014

Gynecol Obstet Invest

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Background: To evaluate and compare the efficacy of vaginal misoprostol and a rectal nonsteroidal anti-inflammatory drug (NSAID) on pain relief during Pipelle endometrial biopsies in a placebo-controlled randomized study. Methods: One hundred and fifty-one women who had an indication for a Pipelle endometrial biopsy were randomized into three groups as follows: group 1, vaginal misoprostol; group 2, rectal NSAID, and group 3, control. After the procedure, the women were asked to record their pain severity on a visual analog scale. The secondary outcome of the study was patient acceptability, and vasovagal symptoms and analgesic requirements after the procedure were also recorded. Results: There were no statistically significant differences in the demographic characteristics of the patients. The primary study outcome was the comparison of the median visual analog scale pain scores of groups 1 and 2 versus group 3 (controls); no statistically significant differences were found (p = 0.502). In addition, the patient acceptability (Likert scale), vasovagal symptoms and analgesic requirements after the procedure were similar among the groups (p = 0.204, 1 and 0.546, respectively). Conclusion: Our study did not demonstrate a reduction in pain relief during Pipelle endometrial biopsies for patients receiving vaginal misoprostol or a rectal NSAID when compared to patients receiving placebo treatment.

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Section: Discussionmentioning

confidence: 99%

“…Poomtavorn and Phupong [22] administered 50 mg of rofecoxib, an NSAID, 60 min prior to uterine curettage under a paracervical bloc and were not able to demonstrate a significant pain reduction during the procedure. They also suggested that prostaglandins are not the main source of pain during the procedure.…”

Section: Discussionmentioning

confidence: 99%

Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

Telli

Aydın²,

Öge

et al. 2014

Gynecol Obstet Invest

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“…The largest trial of NSAIDs prior to IUD insertion used ibuprofen 400 mg, a dose lower than is commonly recommended in the United States [7]. Interestingly, NSAIDs are often recommended prior to other office-based gynecologic procedures, such as colposcopy [8], endometrial biopsy [9] and dilation and curettage [10][11][12], though data are mixed about their effectiveness with these procedures as well.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

et al. 2015

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TitleProphylactic ibuprofen does not improve pain with IUD insertion: a randomized trial. AbstractObjective: To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design: We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion.Results: A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions: Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

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“…Öte yandan rofekoksib, etorikoksib ve naproksen sodyum gibi NSAID'lerin analjezik etkinliğinin araştırıldığı diğer çalışmalarda, tek başına kullanıldıklarında NSAİD'lerin plaseboya göre anlamlı etkilerinin gözükmediği saptanmıştır (4,(19)(20)(21). Bununla beraber Doğan ve ark.…”

Section: Discussionunclassified

Endometriyal biopsi işlemi öncesinde kullanılan oral Hyosine N Butil Bromur’ün analjezik etkinliği

Akdemir

Sel

Aynali

et al. 2019

Zeynep Kamil Tıp Bülteni

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Objective: To investigate the efficacy of oral 10 mg Hyoscine N Butyl Bromur (HBB) on pain perception of the patients who underwent endometrial biopsy with Pipelle. Material and Methods: The charts of the patients who were 18-49 years and underwent endometrial biopsy with Pipelle for evaluation of abnormal uterine bleeding at Zonguldak Bülent Ecevit University, between September 2018 and September 2019 were retrospectively evaluated. 48 patients were seperated as HBB Group who used oral 10 mg HBB 30 minutes before endometrial biopsy and 56 patients as Control Group who did not used any pain relief medication before endometrial biopsy. Results: There were no statistically significant difference between two groups in age, BMI, parity, number of vaginal and cesarean births, nulliparity, multipartiy, and menopausal status. On the other hand, VAS (0) scores which were recorded immediately after endometrial biopsy and VAS (30) scores which were recorded 30 minutes after endometrial biopsy of the patients of the HBB Group were lower than the Control Group

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Prospective randomized, double-blinded, placebo-controlled trial of preoperative rofecoxib for pain relief in uterine curettage

Abstract: The preoperative administration of rofecoxib was not effective in reducing pain in uterine curettage.

Cited by 14 publications

References 19 publications

Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

Endometriyal biopsi işlemi öncesinde kullanılan oral Hyosine N Butil Bromur’ün analjezik etkinliği

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