Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Abstract

Background: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. Objective: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. Methods: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm², n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm², n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. Results: Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064). Conclusion: UV-free blue light home treatment is safe and improves Pv plaques.

Shedding light on the variability of optical skin properties: finding a path towards more accurate prediction of light propagation in human cutaneous compartments

“…Application of visible and NIR light for therapeutic purposes covers a whole spectrum of cutaneous interventions across both cosmetic and medical domains. Examples include removal of vascular and pigmentary lesions [6], unwanted hair [7], and tattoos [8] to wound healing [9], scar resurfacing [10], skin rejuvenation [11,12], and stimulation of hair growth [13][14][15], treatment of psoriasis and eczema [16,17] and more [18]. Effective therapeutic modalities, which rely on all five types of light-tissue interactions (plasma ablation, photodisruption, photoablation, photothermolysis and photochemical reactions), and where the impact of photons on tissue depends on the wavelength, optical power density and exposure time [19], have already been very successfully embraced by a range of professional and home-use devices [20,21].…”

Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome

“…In dermatology, application of PBM spans the cosmetic and medical fields including androgenetic alopecia 7, 8 , alopecia areata 9 , skin rejuvenation 10 , wound healing 11 and alleviation of psoriasis vulgaris and atopic dermatitis symptoms 12, 13 , where many commercialized professional and home-use devices exist 3, 14 .…”

Effects of blue light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects

“…Additional evidence in this respect came from in vitro studies using HaCaT cells, where gene expression analysis showed downregulated pathways implicated in inflammatory responses, and using dendritic cells, where a reduced ability to release pro‐inflammatory cytokines was shown . At the clinical level, the recently reported positive impact of blue light on alleviating symptoms of psoriasis vulgaris (PV) and atopic dermatitis (AD), chronic inflammatory skin diseases characterized by hyperproliferation and inflammatory infiltrates, holds promise for its therapeutic potential …”