Prospective Randomized Trial of LLETZ versus Laser Ablation in Patients with Cervical Intraepithelial Neoplasia

Rd, Alvarez; Cw, Helm; Rp, Edwards; Naumann, R. Wendel; Ee, Partridge; Hm, Shingleton; Ja, McGee; Jb, Hall; Rv, Higgins; Jm, Malone

doi:10.1006/gyno.1994.1027

Cited by 80 publications

(23 citation statements)

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“…The recurrent rate of CIN treated with LEEP in the present study was 2.8%; this rate was substantially lower when compared with the rates of 5-24% in previous reports (Alvarez et al, 1994;Ayhan et al, 2009;Lodi et al, 2011). The glandular involvement and positive margins in the LEEP specimen were potential factors for disease recurrence (Kietpeerakool et al, 2007;Lodi et al, 2011;Kir et al, 2012).…”

Section: Discussioncontrasting

confidence: 52%

Long-term Outcomes of a Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia in a High Incidence Country

Sangkarat

Ruengkhachorn²,

Benjapibal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 52%

Long-term Outcomes of a Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia in a High Incidence Country

Sangkarat

Ruengkhachorn²,

Benjapibal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Only 11 cases were considered treatment failures. Failure rates between 5% and 15% have been reported by other authors (1,2,5,11,16,29). The rate of treatment failure in our study is higher (18.6%).…”

Section: Resultssupporting

confidence: 54%

Human Papillomavirus Infection After Treatment for High-Grade Cervical Intraepithelial Neoplasia

Shikova

Ivanova

Žvirblienė

et al. 2012

Biotechnology & Biotechnological Equipment

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“…LEEP is highly effective and offers the following advantages: (a) unlike ablative techniques, LEEP provides a tissue specimen for histologic evaluation, and (b) compared with cold knife conization, LEEP removes less normal tissue (2,3). However, following LEEP, f10% of women have CIN2+ due to either residual or recurrent disease (2,3).…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Testing Following Loop Electrosurgical Excision Procedure Identifies Women at Risk for Posttreatment Cervical Intraepithelial Neoplasia Grade 2 or 3 Disease

Kreimer

Guido

Solomon

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

104

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Background: Loop electrosurgical excision procedure (LEEP) is the predominant treatment for cervical intraepithelial neoplasia grade 2 or 3 (CIN2+) in the United States, yet following treatment f10% of women are diagnosed again with CIN2+, necessitating close follow-up of such patients. Methods: Surveillance strategies using cytology and/or human papillomavirus (HPV) testing were compared among women who underwent LEEP (n = 610) in the Atypical Squamous Cells of Undetermined Significance (ASCUS) Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study. Cervical specimens, collected at 6-month visits for 2 years, were used for cytology, Hybrid Capture 2 (HC2) detection of carcinogenic HPVs, and PCR for genotyping of carcinogenic and noncarcinogenic HPV types. At exit, women had colposcopy for safety and disease ascertainment. Results: At the visit post-LEEP (median time: 4.5 months after LEEP), 36.9% [95% confidence interval (95% CI), 32.7-41.1%] of women were positive for carcinogenic HPV by PCR and 33.7% (95% CI, 29.7-37.9) had ASCUS or more severe (AS-CUS+) cytology. The overall 2-year cumulative incidence of histologically confirmed posttreatment CIN2+ was 7.0%; this could be further stratified by the HPV risk category detected

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Prospective Randomized Trial of LLETZ versus Laser Ablation in Patients with Cervical Intraepithelial Neoplasia

Cited by 80 publications

References 0 publications

Long-term Outcomes of a Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia in a High Incidence Country

Long-term Outcomes of a Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia in a High Incidence Country

Human Papillomavirus Infection After Treatment for High-Grade Cervical Intraepithelial Neoplasia

Human Papillomavirus Testing Following Loop Electrosurgical Excision Procedure Identifies Women at Risk for Posttreatment Cervical Intraepithelial Neoplasia Grade 2 or 3 Disease

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