2017
DOI: 10.1111/os.12304
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Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts

Abstract: Stem cell research has been a popular topic in the past few decades. This review aims to discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) differentiation into osteoblasts for bone regeneration. The factors analyzed include bone morphogenic protein (BMP), transforming growth factor β (TGF-β), stromal cellderived factor 1 (SDF-1), insulin-like growth factor type 1 (IGF-1), histone demethylase JMJD3, cyclin dependent kinase 1 (CDK1), fucoidan, Runx2 transcription factor, and TAZ… Show more

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Cited by 153 publications
(123 citation statements)
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“…TGF‐β initiates the signaling for BMP synthesis in osteoprogenitor cells, inhibits the osteoclast activation, and stimulates osteoclast apoptosis. TGF‐β is required for normal fracture healing . Without these factors, MSCs do not differentiate toward the osteogenic lineage, inhibiting healing .…”
Section: Discussionmentioning
confidence: 99%
“…TGF‐β initiates the signaling for BMP synthesis in osteoprogenitor cells, inhibits the osteoclast activation, and stimulates osteoclast apoptosis. TGF‐β is required for normal fracture healing . Without these factors, MSCs do not differentiate toward the osteogenic lineage, inhibiting healing .…”
Section: Discussionmentioning
confidence: 99%
“…Reports have indicated that T1DM patients have an approximately fivefold higher risk of hip fracture compared with individuals without diabetes, which is partly due to the reduced bone mineral density (BMD) and bone quality . Bone regeneration is a complex process with overlapping phases in which bone marrow mesenchymal stem cells (BMSCs) play a central role . During the bone regeneration process, BMSCs are recruited and induced to migrate, proliferate, and differentiate into osteoblasts, which can synthesize proteoglycans, type I collagen and other noncollagenous proteins for bone matrix mineralization .…”
Section: Introductionmentioning
confidence: 99%
“…Bone regeneration is a complex process with overlapping phases in which bone marrow mesenchymal stem cells (BMSCs) play a central role . During the bone regeneration process, BMSCs are recruited and induced to migrate, proliferate, and differentiate into osteoblasts, which can synthesize proteoglycans, type I collagen and other noncollagenous proteins for bone matrix mineralization . Recently, researchers have demonstrated that T1DM and hyperglycemia adversely affect the osteogenic potential of BMSCs .…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, as a cell proliferation-associated gene, CDK1 was reported to be an important driver for MM disease progression [20,21]. Besides, previous studies also showed that the downregulation of CDK1 was related to osteogenic differentiation disorder and senescence of MSCs [22][23][24]. In addition, it was interesting that expression knockdown of CDK1 resulted in significantly increased adipogenic differentiation of AD-MSCs [25].…”
Section: Discussionmentioning
confidence: 99%