This study uses computational fluid dynamics (CFD) models for an improved performance of secondary settling tanks, taking as a case study. Unlike previous studies, which focused primarily on simulations of real-time clarifiers by independent measures, this study combines different operating criteria and geometric standards on clarifiers to estimate the SST ultimate capacity. Numerical simulations were performed to assess the SST hydraulic performance under different conditions in order to (i) eliminate vortex zones; (ii) optimize the surface overflow rate (SOR) and predict sludge blanket height (SBH), and finally, (ii) estimate SST ultimate capacity. Based on the current configuration of the SST of Souk-Ahras WWTP, its hydraulic treatment capacity was found to be 49,000 m3/d. The results obtained, which were validated by field observations, showed that optimizing the different parameters yields a significantly improved SST performance. Furthermore, the tests considered were shown to be satisfactorily correlated with SOR. Validation using the receiver operating characteristic (ROC) curve analysis yielded an area under curve (AUC) value of 90%, implying thereby a reasonably good performance. Indeed, optimization resulted in increased solid removal efficiency and increased SOR to 1.4 m/h (compared to 0.8 m/h in literature) without overflow beyond the SBH.