1988
DOI: 10.1002/mpo.2950160302
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Prospective study of childhood acute lymphocytic leukemia: Hematologic, immunologic, and cytogenetic correlations

Abstract: We studied the karyotype in 81 consecutively diagnosed children with acute lymphocytic leukemia (ALL) treated at one institution on a randomized treatment protocol. In 75 patients (93%), a morphological cytogenetic result was obtained, and 57 (65%) were successfully G-banded. Of the 75 patients, 46 (61%) showed abnormal chromosomes, mainly hyperdiploidy and pseudodiploidy, and 29 had no detectable abnormality. Our findings confirmed that the karyotype has prognostic significance. Duration of complete remission… Show more

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Cited by 25 publications
(5 citation statements)
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“…Subsequently, Kaneko et al (1981) described six children who all achieved complete remission (CR) after induction treatment comprised only of vincristine and prednisolone and who remained in CR for several years. During the following years, numerous studies confirmed the favorable outcome of this cytogenetic subgroup (Kaneko et al, 1982;Williams et al, 1982;Harbott et al, 1987;Heinonen et al, 1988;Michael et al, 1988;Prigogina et al, 1988;Bloomfield et al, 1989;Fenaux et al, 1989;Secker-Walker et al, 1989), and by the end of the 1980s, the favorable prognosis of high hyperdiploid ALL had become widely recognized.…”
Section: Immunophenotypic Featuresmentioning
confidence: 86%
See 1 more Smart Citation
“…Subsequently, Kaneko et al (1981) described six children who all achieved complete remission (CR) after induction treatment comprised only of vincristine and prednisolone and who remained in CR for several years. During the following years, numerous studies confirmed the favorable outcome of this cytogenetic subgroup (Kaneko et al, 1982;Williams et al, 1982;Harbott et al, 1987;Heinonen et al, 1988;Michael et al, 1988;Prigogina et al, 1988;Bloomfield et al, 1989;Fenaux et al, 1989;Secker-Walker et al, 1989), and by the end of the 1980s, the favorable prognosis of high hyperdiploid ALL had become widely recognized.…”
Section: Immunophenotypic Featuresmentioning
confidence: 86%
“…Subsequent studies during the 1980s showed that the high hyperdiploid cases were characterized by the expression of the ''common'' (CD10) ALL antigen (Third International Workshop on Chromosomes in Leukemia, 1981a,b;Kaneko et al, 1982;Williams et al, 1982;Heerema et al, 1985;Smets et al, 1985;Harbott et al, 1987;Heinonen et al, 1988;Michael et al, 1988;Pui et al, 1988b;Fenaux et al, 1989;Secker-Walker et al, 1989;Uckun et al, 1989). As more surface markers were identified and used in immunophenotypic analyses, it gradually became apparent that high hyperdiploid lymphoblasts typically are positive for TdT, HLA-DR, CD10, CD19, CD22, CD24, CD34, and CD66c and negative for CD13, CD33, CD45, CD65, cIg, and sIg Behm et al, 1992; Groupe Français de Cytogé né tique Hé matologique, 1993;Lavabre-Bertrand et al, 1994;Raimondi et al, 1996;Hrušá k et al, 1998;Hruîsá k and PorwitMacDonald, 2002).…”
Section: Immunophenotypic Featuresmentioning
confidence: 97%
“…A recent study of a similar sized group also failed to show survival differences between the conventional cytogenetic groups,6 but others have suggested that high hyperdiploidy confers an advantage,4 [11][12][13][14][15] whereas hypodiploidy bodes ill.9 These discrepancies may partly be due to small numbers and incomplete follow up, though it is at least possible that the prognostic importance of cytogenetic features could be modified by improvements in treatment. 6 There did seem to be an increased risk of CNS relapse with certain karyotypes.…”
Section: Discussionmentioning
confidence: 99%
“…Three cases are variants of t($ll), five of t(9;11), and two of t(ll;l9); three involve other translocation partners. In the three t(4;ll) variants, the movement of 4q to l l q is conserved, whereas l l q is translocated to the third, variable chromosome (Bastard et al, 1985;Testa et al, 1986;Michael et al, 1988). All five t(9;ll) variants involve the translocation of 9p to llq, with the translocation of l l q to another chromosome (Harris et al, 1988Koller et al, 1989Raimondi et al, @ 1992 Wiley-Liss, Inc. 1989).…”
mentioning
confidence: 99%