Prospective Study of Chlamydial Infection in Neonates

Schachter, Julius; Grossman, Moses; Holt, Jane; Sweet, Richard L.; Goodner, Ernest K.; Mills, John A.

doi:10.1016/s0140-6736(79)90400-8

Cited by 140 publications

(36 citation statements)

References 16 publications

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“…trachomatis infection, a prevalent sexually transmitted proved a definite role of C. trachomatis infection in adverse disease, is associated with complications like ectopic pregnancy outcome. [1][2][3][4] If not treated on time their newborns pregnancy, fallopian tube block and adverse pregnancy run a 20-40% risk of developing chlamydial conjunctivitis [7][8][9] outcome. [1][2][3][4] In majority of the women the infection with this and a 10-20% risk of developing chlamydial pneumonia.…”

Section: Abstract: Chlamydia Trachomatis Antigen Blocking Antibodymentioning

confidence: 99%

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Chlamydia trachomatisantigen detection in pregnancy and its verification by antibody blocking assay

Malenie

Mathur

2006

Indian J Med Microbiol

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Purpose: To detect the prevalence of genital infection caused by Chlamydia trachomatis in pregnant women and also to confirm the positive results using blocking antibody assay. Methods: Endocervical specimens were collected from 200 symptomatic and asymptomatic pregnant women attending the ANC OPD at M P Shah Medical College, Jamnagar. The samples were tested for presence of Chlamydia trachomatis antigen using the monoclonal antibody. Blocking antibody assay was used to further verify the positive results. Results: Out of 200 pregnant women, 38 (19%) were found positive for Chlamydia trachomatis antigen. Out of the 68 symptomatic patients, C. trachomatis antigen was detected in 26.4%. After verification of the positive samples 13.6% of the asymptomatic pregnant women were found to be harbouring the infection in their genital tract. Two (5.2%) out of the 38 positive samples, on verification with the blocking antibody assay, were found to be false positive by IDEIA, TM thus the specificity of the IDEIA TM being 94.8%. In patients with previous history of abortions, 27.7% were tested positive for C. trachomatis infection. Conclusions: Significant number of pregnant women shad C. trachomatis antigen in their endocervical canal, which can be easily diagnosed by this simple enzyme immuno assay having a specificity of 94.8%. Verification of positive results by antibody blocking assay can further improve the specificity of this non-culture test. Asymptomatic patients should also be screened for the infection. History of previous abortions places the patient at a higher risk for C. trachomatis infection thus such patients should be definitely tested for chlamydia infection. Key words: Chlamydia trachomatis, antigen, blocking antibody, pregnancyC. trachomatis infection, a prevalent sexually transmitted proved a definite role of C. trachomatis infection in adverse disease, is associated with complications like ectopic pregnancy outcome. [1][2][3][4] If not treated on time their newborns pregnancy, fallopian tube block and adverse pregnancy run a 20-40% risk of developing chlamydial conjunctivitis [7][8][9] outcome. [1][2][3][4] In majority of the women the infection with this and a 10-20% risk of developing chlamydial pneumonia. 7,9,10 organism is asymptomatic or with minimal symptoms. Studies from India have reported that 15% of young Therefore, screening of women at risk is highly recommended. asymptomatic women are positive for this infection. 11 In this study, an effort was made to detect C. trachomatis antigen Women at highest risk often have the least access to health from the endocervical specimens of the pregnant women and care facilities. Therefore there is a need for a rapid, simple and to verify the positive results with the antibody blocking assay accurate test to detect C. trachomatis infection, which can so as to achieve the most accurate results. be performed outside the laboratory setting when the patient is still in the clinical setting. Materials and Methods Detection of C. trachomatis infection b...

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Section: Abstract: Chlamydia Trachomatis Antigen Blocking Antibodymentioning

confidence: 99%

“…[1][2][3][4] In majority of the women the infection with this and a 10-20% risk of developing chlamydial pneumonia. 7,9,10 organism is asymptomatic or with minimal symptoms. Studies from India have reported that 15% of young Therefore, screening of women at risk is highly recommended.…”

Section: Abstract: Chlamydia Trachomatis Antigen Blocking Antibodymentioning

confidence: 99%

Chlamydia trachomatisantigen detection in pregnancy and its verification by antibody blocking assay

Malenie

Mathur

2006

Indian J Med Microbiol

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“…The prevalence of urogenital Ct infection is known to be high in women attending antenatal clinics in the Solomon Islands 25 , which probably explains the high seroprevalence in adults as anti-Pgp3 antibodies do not distinguish between biovars. Exposure during parturition may also be a major contributor to the 10% of 1-year-olds in our study who had evidence of prior Pgp3 exposure 27 .…”

Section: Discussionmentioning

confidence: 80%

Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with Chlamydia trachomatis

Butcher¹,

Sokana²,

Jack³

et al. 2018

Wellcome Open Res

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Background: The low population-prevalence of trachomatous trichiasis and high prevalence of trachomatous inflammation–follicular (TF) provide contradictory estimates of the magnitude of the public health threat from trachoma in the Solomon Islands. Improved characterisation of the biology of trachoma in the region may support policy makers as they decide what interventions are required. Here, age-specific profiles of anti-Pgp3 antibodies and conjunctival scarring were examined to determine whether there is evidence of ongoing transmission and pathology from ocular Chlamydia trachomatis (Ct) infection. Methods: A total of 1511 individuals aged ≥1 year were enrolled from randomly selected households in 13 villages in which >10% of children aged 1–9 years had TF prior to a single round of azithromycin mass drug administration undertaken six months previously. Blood was collected to be screened for antibodies to the Ct antigen Pgp3. Tarsal conjunctival photographs were collected for analysis of scarring severity. Results: Anti-Pgp3 seropositivity was 18% in 1–9 year olds, sharply increasing around the age of sexual debut to reach 69% in those over 25 years. Anti-Pgp3 seropositivity did not increase significantly between the ages of 1–9 years and was not associated with TF (p=0.581) or scarring in children (p=0.472). Conjunctival scars were visible in 13.1% of photographs. Mild (p<0.0001) but not severe (p=0.149) scars increased in prevalence with age. Conclusions: Neither conjunctival scars nor lymphoid follicles were associated with antibodies to Ct, suggesting that they are unlikely to be a direct result of ocular Ct infection . Clinical signs of trachoma were prevalent in this population but were not indicative of the underlying rates of Ct infection. The current World Health Organization guidelines for trachoma elimination indicated that this population should receive intervention with mass distribution of antibiotics, but the data presented here suggest that this may not have been appropriate.

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“…A pneumonia por C. trachomatis foi descrita por Schacter et al 28 em 1975 em uma criança pós-recuperação de uma conjuntivite de inclusão. Os achados clínicos, descritos por Benn; Saxon 26 ,em 1977, manifestam-se geralmente entre a segunda e 16ª semana de vida no RN; o quadro respiratório costuma ser mais grave que no lactente, com aumento progressivo da freqüência respiratória (entre 50 e 70 movimentos respiratórios/minuto), cianose, deterioração do estado geral à ausculta pulmonar, roncos e estertores crepitantes difusos 29,30 .…”

Section: Pneumoniaunclassified

Infecção por Chlamydia trachomatis no período neonatal: aspectos clínicos e laboratoriais. Experiência de uma década: 1987-1998

Vaz¹,

Ceccon²,

Diniz³

1999

Rev. Assoc. Med. Bras.

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Prospective Study of Chlamydial Infection in Neonates

Cited by 140 publications

References 16 publications

Chlamydia trachomatisantigen detection in pregnancy and its verification by antibody blocking assay

Chlamydia trachomatisantigen detection in pregnancy and its verification by antibody blocking assay

Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with Chlamydia trachomatis

Infecção por Chlamydia trachomatis no período neonatal: aspectos clínicos e laboratoriais. Experiência de uma década: 1987-1998

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