Prospective study of iron metabolism and RLS in blood donors

Triguero, L. Lillo; Guillem, A; Castillo, Alejandro; Valdés, I.; Rio, R. Del; Peraita-Adrados, Rosa

doi:10.1016/j.sleep.2015.02.180

Cited by 2 publications

(4 citation statements)

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“…The main finding of our study is consistent with other population‐based studies that also found no association between RLS and measures of iron stores (Benediktsdottir et al, ; Berger et al, ; Didriksen et al, ; Lillo‐Triguero et al, ). We extend those findings by showing a lack of association in young adults.…”

Section: Discussionsupporting

confidence: 92%

“…In children, it has been reported that the frequency of RLS is higher if ferritin levels are < 50 µg L −1 (Halac et al, 2015), and that low serum ferritin may contribute to the severity of symptoms (Picchietti & Picchietti, 2010). However, other studies have failed to show associations between measures of iron stores and RLS (Benediktsdottir et al, 2010;Berger et al, 2002;Didriksen et al, 2017;Lillo-Triguero, Castillo-Rueda, Valdés-Gross, Guillem-Mesado, & Río-Villegas, 2016), and a systematic review from 2012 assessing six studies did not find sufficient evidence to determine whether iron therapy is beneficial for the treatment of RLS (Trotti, Bhadriraju, & Becker, 2012). It remains unclear if serum ferritin is a risk marker for RLS or a predictor for RLS severity.…”

Section: Introductionmentioning

confidence: 99%

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Are serum ferritin and transferrin saturation risk markers for restless legs syndrome in young adults? Longitudinal and cross‐sectional data from the Western Australian Pregnancy Cohort (Raine) Study

Lammers

Curry‐Hyde

Smith

et al. 2018

Journal of Sleep Research

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Restless legs syndrome has been associated with serum iron deficiency in clinical studies. However, studies investigating this relationship have had inconsistent results and there are no studies in young adults. Therefore, we investigated the relationship between serum measures of iron stores and restless legs syndrome in young adults in the community. Participants in the Western Australian Pregnancy Cohort (Raine) Study answered questions on restless legs syndrome (n = 1,100, 54% female) at age 22 years, and provided serum measures of iron stores (ferritin and transferrin saturation) at ages 17 and 22 years. Restless legs syndrome was diagnosed when four International RLS Study Group criteria were met (urge to move, dysaesthesia, relief by movement, worsening during evening/night) and these symptoms occurred ≥5 times per month. Logistic regression was used to assess associations between serum iron stores and restless legs syndrome, adjusting for potential confounders. The prevalence of restless legs syndrome at age 22 years was 3.0% (n = 33, 70% female). Among those who provided restless legs syndrome and iron data at age 22 years (n = 865), the median (interquartile range) ferritin was not different between the restless legs syndrome (55 [29.5-103.5] µg L ) and the non-restless legs syndrome group (65.0 [35.0-103.3] µg L , p = 0.2), nor were there differences in iron deficiency prevalence (p = 0.36). There was no association between restless legs syndrome (22 years) and iron stores (17, 22 years) before or after adjustment for potential confounders. There was no association between restless legs syndrome at 22 years and iron stores at 17 or 22 years in this cohort. Serum iron stores may not be a useful indicator of restless legs syndrome risk in young adults in the community.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Are serum ferritin and transferrin saturation risk markers for restless legs syndrome in young adults? Longitudinal and cross‐sectional data from the Western Australian Pregnancy Cohort (Raine) Study

Lammers

Curry‐Hyde

Smith

et al. 2018

Journal of Sleep Research

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“…Sleep apnea was also reported to be prevalent in more than half of the patients with ESRD among the three dialysis centers in Jeddah, Saudi Arabia [ 24 ]. Patients undergoing either HD or PD were both found to suffer from recurring sleep disturbance with noted mood disorders and restless leg syndrome [ 25 ]. However, the study did not determine the factors that might influence sleep quality [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients undergoing either HD or PD were both found to suffer from recurring sleep disturbance with noted mood disorders and restless leg syndrome [ 25 ]. However, the study did not determine the factors that might influence sleep quality [ 25 ]. In view of the concluded studies regarding patients with CKD undergoing HD and its apparent effects on their sleep quality, the mentioned factors and problems in this aspect remain understudied.…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality and Its Affecting Factors among Hemodialysis Patients: A Multicenter Cross-Sectional Study

Alshammari,

Alkubati,

Pasay-an

et al. 2023

Healthcare

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(1) Background: Sleep quality is one of the most important clinical outcomes of hemodialysis (HD) patients, as it can affect their physical and mental health. This study aimed to investigate sleep quality and its affecting factors among patients with HD. (2) Methods: A cross-sectional design was used to investigate the quality of sleep among HD patients in two cities in Saudi Arabia. The data were collected during the period from January to December 2022. A convenience sample of 250 HD patients was selected in this study. Data were collected using the Arabic version of the Pittsburgh Sleep Quality Index (PSQI). (3) Results: About two-thirds of participants (63.6%) had normal sleep, while one-third had poor sleep (36.4%). There was a significant relationship between the participants’ age and the quality of sleep, where participants who were aged more than 50 had poorer sleep than those who were younger (p < 0.001). Male and married participants significantly had poor sleep more than female and single participants (p = 0.011 and 0.015, respectively). In addition, participants who were retired, had a higher number of dependents, did not adhere to exercise, and had more comorbidities had significantly poorer sleep than other groups (p = 0.002, 0.016, 0.023, and <0.001, respectively). The level of education, financial status, distance from home to dialysis center, and participants’ satisfaction at the time of dialysis had no influence on the quality of sleep among HD patients. The multiple linear regression shows that exercise (p = 0.017), the number of comorbidities (p = 0.008), and the duration of dialysis (p < 0.020) were the independent factors affecting the quality of sleep among HD patients. (4) Conclusions: About one-third of HD patients in this study had poor sleep. There were significant differences between patients’ age, gender, marital status, and sleep-quality levels. Moreover, participants who retired, had a higher number of dependents, did not adhere to exercise, and had more comorbidities had significantly poorer sleep than other groups. Future studies should develop appropriate interventions to address the problem of poor sleep quality among HD patients.

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Prospective study of iron metabolism and RLS in blood donors

Cited by 2 publications

References 0 publications

Are serum ferritin and transferrin saturation risk markers for restless legs syndrome in young adults? Longitudinal and cross‐sectional data from the Western Australian Pregnancy Cohort (Raine) Study

Are serum ferritin and transferrin saturation risk markers for restless legs syndrome in young adults? Longitudinal and cross‐sectional data from the Western Australian Pregnancy Cohort (Raine) Study

Sleep Quality and Its Affecting Factors among Hemodialysis Patients: A Multicenter Cross-Sectional Study

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