Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Camilleri, Michael; McKinzie, Sanna; Busciglio, Irene; Low, Phillip A.; Sweetser, Seth; Burton, Duane D.; Baxter, Kari; Ryks, Michael; Zinsmeister, Alan R.

doi:10.1016/j.cgh.2008.02.060

Cited by 214 publications

(190 citation statements)

References 64 publications

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“…29 Psychological or affective disorders have been shown to be strongly associated with IBS. 30 There was an improvement in diagnostic test accuracy when other investigators added these to a biomarker panel in a recent study. 17 Rates of somatoform-type behavior, in particular, have been shown to be significantly higher in patients with IBS, 31 and to differentiate IBS from health with greater accuracy, compared with markers of anxiety and depression.…”

Section: Diagnostic Performance Of Rome III Criteriamentioning

confidence: 99%

Enhancing Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by Additional History and Limited Diagnostic Evaluation

Sood

Camilleri

Gracie

et al. 2016

American Journal of Gastroenterology

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Section: Diagnostic Performance Of Rome III Criteriamentioning

confidence: 99%

Enhancing Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by Additional History and Limited Diagnostic Evaluation

Sood

Camilleri

Gracie

et al. 2016

American Journal of Gastroenterology

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“…A total of six studies were included. 15,17,18,37,38,65 In those studies, healthy-control groups were used for multiple comparisons with the three IBS-subtypes; we divided the healthy-control group into three groups for meta-analysis of three IBS-subtypes alongside healthy controls. Depression levels were significantly higher in IBS-C (SMD = 0.83; 95% CI, 0.61-1.06; I 2 = 0%; P < 0.001), IBS-D (SMD = 0.73; 95% CI, 0.51-0.96; I 2 = 0%; P < 0.001), and IBS with mixed bowel habits (SMD = 0.62; 95% CI, 0.39-0.84; I 2 = 0%; P < 0.001) (Fig.…”

Section: Depression and Anxiety In Irritable Bowel Syndrome-subtypementioning

confidence: 99%

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

177

151

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Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes. ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.

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“…Update on Irritable Bowel Syndrome Program of Research (Camilleri et al, 2008). A current hypothesis is that abnormal microbiota activate mucosal innate immune responses which increase epithelial permeability, activate nociceptive sensory pathways and dysregulate the enteric nervous system (Arumugam et al, 2011;.…”

Section: Microbiomementioning

confidence: 99%

Update on Irritable Bowel Syndrome Program of Research

2013

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Purpose: This article provides an update and overview of a nursing research program focused on understanding the pathophysiology and management of irritable bowel syndrome (IBS). Methods: This review includes English language papers from the United States, Europe, and Asia (e.g., South Korea) from 1999 to 2013. We addressed IBS as a health problem, emerging etiologies, diagnostic and treatment approaches and the importance of a biopsychosocial model. Results: IBS is a chronic, functional gastrointestinal disorder characterized by recurrent episodes of abdominal pain and alterations in bowel habit (diarrhea, constipation, mixed). It is a condition for which adults, particularly women ages 20-45, seek health care services in both the United States and South Korea. Clinically, nurses play key roles in symptom prevention and management including designing and implementing approaches to enhance the patients' self-management strategies. Multiple mechanisms are believed to participate in the development and maintenance of IBS symptoms including autonomic nervous system dysregulation, intestinal inflammation, intestinal dysbiosis, dietary intolerances, alterations in emotion regulation, heightened visceral pain sensitivity, hypothalamic-pituitary-adrenal dysregulation, and dysmotility. Because IBS tends to occur in families, genetic factors may also contribute to the pathophysiology. Patients with IBS often report a number of co-morbid disorders and/or symptoms including poor sleep. Conclusion: The key to planning effective management strategies is to understand the heterogeneity of this disorder. Interventions for IBS include non-pharmacological strategies such as cognitive behavior therapy, relaxation strategies, and exclusion diets.

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Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Abstract: Background/Aim-To assess pathophysiology in irritable bowel syndrome (IBS).

Cited by 214 publications

References 64 publications

Enhancing Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by Additional History and Limited Diagnostic Evaluation

Enhancing Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by Additional History and Limited Diagnostic Evaluation

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Update on Irritable Bowel Syndrome Program of Research

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