Prospective study of risk factors in natural rubber latex hypersensitivity

Moneret‐Vautrin, D.A.; Beaudouin, É.; Widmer, S.; Mouton, C.; Kanny, G.; Prestat, Frédérique; Kohler, Chantal; Feldmann, L.

doi:10.1016/s0335-7457(05)80410-1

Cited by 33 publications

(67 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the prevalence of sensitization was determined by SPT, the most sensitive diagnostic method (30,31,40,47,48), using three commercial latex extracts. SPT were performed with no adverse reaction, contrary to Kelly et al (31), who found a prevalence of 8 % of systemic reactions.…”

Section: Discussionmentioning

confidence: 99%

“…Rubber industry workers also have high sensitization prevalence (21). Atopy also seems to be another risk factor of latex sensitization, mainly if associated with frequent contact to latex products (22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

“…Several published studies found prevalences between 4.3 % and 73.3 % (table I) (5)(6)(7)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). The variability of results can be related with differences in the methodology, namely variables related with the population in study (dimension and age group) or the diagnostic method (SPT and/or serum IgE determination, absence of allergenic extract standardization and different methodology of SPT).…”

Section: Introductionmentioning

confidence: 99%

“…The high prevalence of sensitization seems to be a result, mainly, of early (33,34,(39)(40)(41) and frequent contact with latex products (7,29,30,33,37,(39)(40)(41)(42)(43). The exposure begins, frequently, in the first day of life, with myelomeningocele surgical closure, and continues during several surgical procedures to correct neurologic, urologic and orthopedic congenital malformations.…”

Section: Introductionmentioning

confidence: 99%

“…The predisposition to produce high levels of specific IgE in response to allergenic exposure, related to a high atopic risk, has been a factor frequently associated to latex sensitization in this population (7,29,30,37,40,41).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Risk factors for latex sensitization in children with spina bifida

Pires

Morais‐Almeida

Gáspár

et al. 2002

Allergologia et Immunopathologia

View full text Add to dashboard Cite

SUMMARYBackground: Children with spina bifida represent the major risk group for latex sensitization.Purpose: To determine the prevalence of latex sensitization in these children and to identify risk factors.Material and methods: We studied 57 patients with spina bifida. The mean age was 5.6 years and the male/female ratio was 0.8/1. In all patients a questionnaire, skin prick test (SPT) with latex (UCBStallergènes, Lofarma and ALK-Abelló), common aeroallergens and fruits (UCB-Stallergènes) and serum determination of total IgE (AlaSTAT) were performed.Results: The prevalence of latex sensitization was 30 %; only two sensitized children (12 %) had symptoms after exposure. Risk factors for latex sensitization were age Ն 5 years (p = 0.008; OR = 6.0; 95 % CI = 1.7-22.1), having at least four previous surgical interventions (p < 0.0001; OR = 18.5; 95 % CI = 3.6-94.8), having undergone surgery in the first 3 months of life (p = 0.008; OR = 5.4; 95 % CI = 0.7-29.2) and total serum IgE Ն 44 IU/ml (p = 0.03; OR = 3.8; 95 %CI = 1.1-13.1). Multiple logistic regression analysis showed that only a history of four or more surgical interventions (p < 0.0001; OR = 26.3; 95 %CI = 2.9-234.2) and total serum IgE Ն 44 IU/ml (p = 0.02; OR = 8.6; 95 % CI = 1.4-53.4) were independently associated with latex sensitization. Sex, family and personal allergic history, hydrocephalus with ventriculoperitoneal shunt, cystourethrograms, intermittent bladder catheterization and atopy were not related to latex sensitization. Conclusions:In children with spina bifida, significant and independent risk factors identified for latex sensitization were multiple interventions and higher levels of total serum IgE. A prospective study will clarify the clinical evolution of assymptomatic children sensitized to latex.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Risk factors for latex sensitization in children with spina bifida

Pires

Morais‐Almeida

Gáspár

et al. 2002

Allergologia et Immunopathologia

View full text Add to dashboard Cite

show abstract

Latex Allergy

Gawchik

2011

Mount Sinai J Medicine

View full text Add to dashboard Cite

Allergy to natural rubber latex is an important clinical condition that occurred after the institution of universal precautions to protect healthcare workers. A rapid increase and production of both examination and surgical gloves resulted in an epidemic of allergy to latex protein. Healthcare workers in both the medical and dental environments, as well as specific groups of individuals including those with spina bifida, myelodysplasia, and food allergies (banana, kiwi, avocado, and others), were at increased risk of sensitization. Clinical symptoms in the latex allergic individual ranged from type I hypersensitivity reaction including rhinoconjunctivitis, asthma, and systemic reaction to type IV hypersensitivity reaction, which occur from the chemicals added during the manufacturing process. Diagnosis of latex allergy is based on a clinical history that correlates the development of symptoms in relationship to exposure. In the United States there are no skin tests approved by the Food and Drug Administration. Therefore a combination of clinical judgment and serologic testing such as ImmunoCAP and Immulite is helpful. The primary treatment of latex allergy is avoidance of exposure to the latex protein.

show abstract

Barrier Protection and Latex Allergy Associated with Surgical Gloves

Korniewics¹,

Kelly²

1995

AORN Journal

View full text Add to dashboard Cite

Latex continues to be the material of choice for surgical gloves because it is resealable and flexible, and it maintains the wearer's tactile sensitivity. The use of latex gloves for barrier protection may need to be reevaluated in light of the increasing number of individuals who are sensitive to latex. Hospital personnel can use low-allergen gloves or nonlatex gloves when caring for patients with known sensitivity to latex; however, only nonlatex gloves may be effectives at reducing or preventing anaphylactic reaction. Health care facilities must develop policies and procedures for dealing with latex-sensitive patients and health care workers.

show abstract

Prospective study of risk factors in natural rubber latex hypersensitivity

Cited by 33 publications

References 44 publications

Risk factors for latex sensitization in children with spina bifida

Risk factors for latex sensitization in children with spina bifida

Latex Allergy

Barrier Protection and Latex Allergy Associated with Surgical Gloves

Contact Info

Product

Resources

About