Prospective study of sexual dysfunction in men with rectal cancer: feasibility and results of nerve sparing surgery

Celentano, Valerio; G, Fabbrocile; Luglio, Gaetano; Antonelli, Giovanni; Tarquini, R.; Bucci, Luigi

doi:10.1007/s00384-010-0995-5

Cited by 45 publications

(31 citation statements)

References 19 publications

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“…ED in the patient with bilateral nerve sparing may have been associated with adjuvant radiochemotherapy and severe reactive depression subsequent to surgery. Taken together, our findings provide strong presumptive evidence that bilateral nerve sparing is an essential prerequisite for maintaining male EF, which is in accordance with previous studies of EF following nerve-sparing rectal cancer surgery [23,24]. It is of note that none of the patients reporting postoperative de novo ED had concomitant lower urinary tract or anorectal dysfunction.…”

Section: Discussionsupporting

confidence: 79%

Intraoperative Monitoring of Bladder and Internal Anal Sphincter Innervation: A Predictor of Erectile Function following Low Anterior Rectal Resection for Rectal Cancer? Results of a Prospective Clinical Study

Kneist¹,

Kauff²,

Rubenwolf

et al. 2013

Dig Surg

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Background: The objective was to investigate whether two-dimensional intraoperative neuromonitoring (IONM) of pelvic autonomic nerves has the potential to predict erectile function (EF) following surgery for rectal cancer. Methods: A consecutive series of 17 sexually active male rectal cancer patients undergoing IONM-based nerve-sparing low anterior rectal resection were evaluated prospectively. IONM was performed by electric stimulation of the pelvic splanchnic nerves with concomitant electromyography of the internal anal sphincter and cystomanometry. Sexual function was assessed using a validated questionnaire. Results: The degree of agreement between electromyography-based and cystomanometry-based IONM with postoperative EF was moderate and good (κ = 0.43 and κ = 0.66). Combined assessment yielded the best agreement (κ = 0.76) with sensitivity of 90%, specificity of 86%, positive predictive value of 90%, negative predictive value of 86%, and overall accuracy of 88%, respectively, in terms of prediction of postoperative EF. Conclusion: The method may be suitable to predict male EF following rectal resection.

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Section: Discussionsupporting

confidence: 79%

Intraoperative Monitoring of Bladder and Internal Anal Sphincter Innervation: A Predictor of Erectile Function following Low Anterior Rectal Resection for Rectal Cancer? Results of a Prospective Clinical Study

Kneist¹,

Kauff²,

Rubenwolf

et al. 2013

Dig Surg

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“…Sexual dysfunction arises in the form of impotence and retrograde ejaculation [32]. In a study investigating the functions following the scarification of the anatomic nerve, it has been reported that inferior hypogastric plexus was related to impotence and superior hypogastric plexus was related to ejaculation [24,33].…”

Section: Discussionmentioning

confidence: 99%

Urinary and sexual dysfunction rates and risk factors following rectal cancer surgery

Duran

Tanrıseven

Ersoz

et al. 2015

Int J Colorectal Dis

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“…They proposed that this was secondary to nerve injury in the hypogastric plexus and autonomic nerves encountered during the dissection of Denonvilliers fascia. Celentano et al 21 showed that avoiding macroscopic damage to nerves intraoperatively (nerve sparing) helps with preserving erectile function. Unfortunately, this technique is not applicable in every patient.…”

Section: Pelvic Surgerymentioning

confidence: 99%

Understanding and Managing Erectile Dysfunction in Patients Treated for Cancer

Voznesensky

Annam

Kreder

2016

JOP

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Cancer can cause sexual adverse effects by direct and indirect pathways. It can involve sexual organs, indirectly affect body image, or cause fatigue or depression with subsequent effects on libido. Erectile dysfunction (ED), the inability to obtain or maintain an erection firm enough for sexual intercourse, can also result from adverse effects of cancer treatment, such as fatigue, pain, or anxiety about therapy. In addition, depressed feelings about having cancer can affect sexuality, causing a range of signs and symptoms that can lead to ED. Chemotherapy, hormone therapy, surgery, and radiation can all cause sexual adverse effects. Additional factors that play a role include patient age and degree of ED before starting cancer treatment. In this article, we discuss how chemotherapy, hormone therapy, surgery, and radiation affect erectile function as well as possible treatment options for ED.

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Prospective study of sexual dysfunction in men with rectal cancer: feasibility and results of nerve sparing surgery

Cited by 45 publications

References 19 publications

Intraoperative Monitoring of Bladder and Internal Anal Sphincter Innervation: A Predictor of Erectile Function following Low Anterior Rectal Resection for Rectal Cancer? Results of a Prospective Clinical Study

Intraoperative Monitoring of Bladder and Internal Anal Sphincter Innervation: A Predictor of Erectile Function following Low Anterior Rectal Resection for Rectal Cancer? Results of a Prospective Clinical Study

Urinary and sexual dysfunction rates and risk factors following rectal cancer surgery

Understanding and Managing Erectile Dysfunction in Patients Treated for Cancer

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