Prospective study of vulvar nevi

Rock, Barbara; Hood, Antoinette F.; Rock, John A.

doi:10.1016/0190-9622(90)70017-c

Cited by 78 publications

(61 citation statements)

References 6 publications

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“…Studies focusing on pigmented lesions on the vulva report that melanotic macules/melanosis are the most frequently encountered diagnoses among women undergoing gynecological visits [13,23]. In contrast, vulvar melanoma is rare with an estimated incidence of 0.10/100,000 women per year.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of Pigmented Lesions of the Vulva: A Retrospective Morphological Study

et al. 2011

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Background: The dermoscopic patterns of pigmented skin tumors are influenced by the body site. Objective: To evaluate the clinical and dermoscopic features associated with pigmented vulvar lesions. Methods: Retrospective analysis of clinical and dermoscopic images of vulvar lesions. The χ² test was used to test the association between clinical data and histopathological diagnosis. Results: A total of 42 (32.8%) melanocytic and 86 (67.2%) nonmelanocytic vulvar lesions were analyzed. Nevi significantly prevailed in younger women compared with melanomas and melanosis and exhibited most commonly a globular/cobblestone (51.3%) and a mixed (21.6%) pattern. Dermoscopically all melanomas showed a multicomponent pattern. Melanotic macules showed clinical overlapping features with melanoma, but their dermoscopic patterns differed significantly from those observed in melanomas. Conclusion: The diagnosis and management of pigmented vulvar lesions should be based on a good clinicodermoscopic correlation. Dermoscopy may be helpful in the differentiation of solitary melanotic macules from early melanoma.

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Section: Discussionmentioning

confidence: 99%

Dermoscopy of Pigmented Lesions of the Vulva: A Retrospective Morphological Study

et al. 2011

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“…52 Vulvar nevi themselves are quite uncommon; in a recent study of 301 new patients in a gynecology practice, the prevalence of melanocytic nevi on vulvar skin was only 2.3%. 55 The atypical features appear to represent a histologic curiosity seen in a minority of vulvar nevi, with no clinical significance except the possibility of diagnostic error. In our consultation practices, we have seen tragic examples of errors that have been followed by unnecessary ablative surgery in young women.…”

Section: Clinical Featuresmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

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Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma.

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“…Although MN in the vulvar area are not so rare, being found in 2.3% of the females, their dermoscopic features had not been described prior to the present study [8]. From our sample of 84 pigmented vulvar lesions, we selected 10 which had been diagnosed as MN by visual inspection alone and then subjected to dermoscopic and histopathological analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Vulvar melanosis is the most common among these disorders, being diagnosed in 7% of the females [8]. Hence, vulvar melanosis has also been the most studied pigmented lesion from a dermoscopical perspective, and its analysis has consented description of various morphological patterns.…”

Section: Discussionmentioning

confidence: 99%

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Vulvar Melanocytic Nevi: A Dermoscopic Investigation

Zampino¹,

Marzola

Corazza³

2010

Dermatology

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Background: Very few dermoscopic investigations into pigmented genital lesions have been performed to date. To the best of our knowledge, no dermoscopical description of vulvar melanocytic nevi (MN) has yet been proposed. Objective: Our aims were to analyze the dermoscopic features of vulvar MN and to review the literature of dermoscopy of the vulvar area. Methods: Among 74 women presenting 84 vulvar pigmented lesions, 10 who received a visual diagnosis of MN were submitted to dermoscopic and histopathological analysis. Results: Histology confirmed the clinical diagnosis of MN in 8 out of 10 cases, while the remaining 2 pigmented lesions were diagnosed as seborrheic keratosis. Vulvar MN were generally found to share similar dermoscopic patterns with their cutaneous equivalent. Conclusions: Although further observation will be necessary to provide additional data and establish key morphological criteria and/or algorithms useful for differentiating between melanocytic and nonmelanocytic vulvar lesions, dermoscopy should be considered an investigative tool, as clinical observation alone may not be sufficient for accurate diagnosis.

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Prospective study of vulvar nevi

Cited by 78 publications

References 6 publications

Dermoscopy of Pigmented Lesions of the Vulva: A Retrospective Morphological Study

Dermoscopy of Pigmented Lesions of the Vulva: A Retrospective Morphological Study

Precursors to melanoma and their mimics: nevi of special sites

Vulvar Melanocytic Nevi: A Dermoscopic Investigation

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