2016
DOI: 10.1016/j.thromres.2016.01.008
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Prospective study of γ′ fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)

Abstract: Introduction Epidemiological studies generally have not found plasma total fibrinogen to be a risk factor for venous thromboembolism (VTE), but several have reported associations between variants in the fibrinogen gamma gene (FGG) and VTE. A case-control study in whites suggested plasma γ′ fibrinogen concentration may be associated inversely with VTE, but this was not replicated in African Americans. Objective To examine the prospective association between γ′ fibrinogen concentrations and occurrence of VTE. … Show more

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Cited by 11 publications
(6 citation statements)
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“…[67][68][69] In general, ↑ γ' is associated with arterial thrombosis, ↓ γ' with venous thrombosis, although this remains inconclusive. 66 Platelet binding Clot sƟffness Clot structure Fibrinolysis Thrombin binding ("anƟthrombin I")…”
Section: Atherosclerosis: Atherosclerosis: Fibrin In Plaques Contribumentioning
confidence: 99%
“…[67][68][69] In general, ↑ γ' is associated with arterial thrombosis, ↓ γ' with venous thrombosis, although this remains inconclusive. 66 Platelet binding Clot sƟffness Clot structure Fibrinolysis Thrombin binding ("anƟthrombin I")…”
Section: Atherosclerosis: Atherosclerosis: Fibrin In Plaques Contribumentioning
confidence: 99%
“…FGG rs20668655 has previously been demonstrated to be significantly associated with lower γ' fibrinogen levels in cross-sectional analyses. 46 Being situated in a cleavage stimulatory factor consensus 2a sequence just downstream of the polyadenylation site of the γA fibrinogen exon 10, the minor allele of rs20668655 may result in the production of more γA and less γ' fibrinogen through increased splicing of intron 9. 18 The coding SNP, rs6050 (Aα Thr312Ala), situated in the αC domain, previously reported to alter clot structure and properties by increased factor XIII cross-linking, 47 did not influence change in clot properties over time.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, minor allele carriers of FGG rs2066865 and FGA rs6050 demonstrated a decrease in % ' fibrinogen over the 10-year period, while levels in homozygous major allele individuals tended to increase. FGG rs20668655 has previously been demonstrated to be significantly associated with lower ' fibrinogen levels in cross-sectional analyses [46]. Being situated in a cleavage stimulatory factor (CstF) consensus 2a sequence just downstream of the polyadenylation site of the A fibrinogen exon 10, the minor allele of rs20668655 may result in the production of more A and less ' fibrinogen through increased splicing of intron 9 [18].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…While there is literature suggestive that SCA patients experience cognitive dysfunction, to our knowledge, no prior studies evaluated SCT and cognitive impairment [5], [6], [7], [8], [9]. It is established that SCT is associated with hypercoagulability [25] and risk of both venous thromboembolism [19] and kidney disease [16], [17], [18], [36], [37]. In an autopsy series of 128 SCT patients, there appeared to be higher rates of visceral infarcts, including in the brain, than those without SCT (18% vs. < 1%) [22], [38].…”
Section: Discussionmentioning
confidence: 99%