Prospective study on central venous line associated bloodstream infections

Wagner, Mine; Bonhoeffer, Jan; Erb, Thomas O.; Glanzmann, René; Häcker, Frank Martin; Paulussen, Michael; Weibel, Daniel; Heininger, Ulrich

doi:10.1136/adc.2010.208595

Cited by 32 publications

(30 citation statements)

References 20 publications

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“…Comparing studies on CLABSI is challenging due to different study population and methodology used. Only another prospective study, conducted in a whole pediatric hospital, is available in literature [10]. This study included 152 patients for overall 14,752 catheter observation days, with a CLABSI rate of 0.95/1000 central line-days [10].…”

Section: Discussionmentioning

confidence: 99%

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Central-line associated bloodstream infections in a tertiary care children’s University hospital: a prospective study

et al. 2016

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BackgroundThe central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children’s university hospital.MethodsThe study involved all children aged less than 18 years admitted to Meyer Children’s University Hospital, Florence, Italy who had a central line access between the October 15th, 2014 and the April 14th, 2015. CLABSI were defined according to the Center for Disease Control and Prevention criteria. CLABSI incidence rates with 95% confidence limits were calculated and stratified for the study variables. For each factor the relative risk and 95% confidence intervals were evaluated. Statistical analysis was performed using the statistical software SPSS for Windows, version 22.0 (SPSS Inc., Chicago, IL), p < 0.05 was considered statistically significant.ResultsCLABSI rate was 3.73/1000 (95% CI: 2.54–5.28) central line-days. A higher CLABSI incidence was seen with female gender (p = 0.045) and underlying medical conditions (excepting prematurity, surgical diseases and malignancy) (p = 0.06). In our study 5 infections, were caused by extended-spectrum β-lactamase producing organisms and in one case by carbapenem-resistant Klebsiella pneumoniae.ConclusionsOur study confirms the spreading of multi-resistant pathogens as causes of healthcare associated infections in children. An increased incidence rate of CLABSI in our study was related to underlying medical conditions. Pediatric studies focusing on healthcare infections in this type of patients should be done in order to deepen our understanding on associated risk factors and possible intervention areas.

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Section: Discussionmentioning

confidence: 99%

“…A Swiss study performed in a single institution between April 2008 and March 2009 on 152 patients showed an overall CLABSI incidence of 0.95/1000 central line-days. In this study, CLABSI incidence varied by type of catheter and by patient’s age, with the highest risk in neonates with Silastic® percutaneous central line [10]. …”

Section: Introductionmentioning

confidence: 99%

Central-line associated bloodstream infections in a tertiary care children’s University hospital: a prospective study

et al. 2016

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“…CLABSI is one of the deadliest types of HAIs, with a mortality rate of 12%-25%. [11][12][13] Several factors, such as those related to the patients (immunodeficiency, need for extracorporeal life support or renal replacement therapy), CVC use (prolonged catheterization, type of CVC material, and anatomical site of insertion and handling), have been shown to increase the risk of CVC infection. 13 Here, we report an epidemiologic study about the CLABSIs in our PICU.…”

Section: Introductionmentioning

confidence: 99%

Central Line-Associated Bloodstream Infections in Pediatric Intensive Care Unit

Kendirli¹,

Yaman²,

Ödek³

et al. 2017

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Introduction:The aim of this study was to determine the frequency of central line-associated bloodstream infections, risk factors, their relationship with catheter insertion location, and the effect of central line-associated bloodstream infections on mortality and pediatric intensive care unit (PICU) length of stay. Methods: This was a prospective, observational and cohort study, carried out between November 2009 and February 2011. During this period, all the patients who had central-line were monitored for central line-associated bloodstream infection. Results: In the study period, 275 patients were admitted to our PICU. The frequency of invasive device usage was 38.9% (107) for central venous catheter, 38.2% (105) for mechanical ventilation, 53.3% (147) for urinary catheter, and 11.3% (32) for artery line. Central lineassociated bloodstream infection was detected in 16 (14.8%) of the patients and 23 central line-associated bloodstream infection attacks were observed. There were 14 central line-associated bloodstream infection attacks in 1.000 central venous catheter usage days. There were 168 patients without central venous catheter and 4 (2.4%) of them had blood stream infection. Thirty-six patients died and the mortality rate was 13%. Five of these patients (13.8%) died due to central line-associated bloodstream infection, 27 (25%) of them had central venous catheter and 9 (6%) of them did not (p=0.001). Conclusion:In conclusion, central line-associated bloodstream infection is one of the serious healthcare-associated infections, and it is an important cause of morbidity and mortality in PICUs. Keywords: Nosocomial infection, central line-associated bloodstream infection, pediatric intensive careGiriş: Bu çalışmanın amacı, kateter ilişkili kan dolaşımı enfeksiyonlarının sıklığını, risk faktörlerini, kateter yerleştirme yerleri ile olan ilişkisini, ayrıca bu enfeksiyonların mortalite ve çocuk yoğun bakım ünitesi (ÇYBÜ) kalış süresine olan etkisini belirlemektir. AbstractÖz

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“…(7) For long-term central venous access, cuffed and tunneled CVCs are associated with a higher risk for CLABSI than totally implanted devices (Porth-a-cath). (10,11,28). However, if the patient needs continuous access for many days or intermittent access day after day, a cuffed and tunneled CVC is preferable to a totally implanted device.…”

Section: Discussionmentioning

confidence: 99%

The risk of central line-associated bloodstream infections with different types of central vascular catheters in a multidisciplinary neonatal and pediatric intensive care unit

2013

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Prospective study on central venous line associated bloodstream infections

Cited by 32 publications

References 20 publications

Central-line associated bloodstream infections in a tertiary care children’s University hospital: a prospective study

Central-line associated bloodstream infections in a tertiary care children’s University hospital: a prospective study

Central Line-Associated Bloodstream Infections in Pediatric Intensive Care Unit

The risk of central line-associated bloodstream infections with different types of central vascular catheters in a multidisciplinary neonatal and pediatric intensive care unit

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