Prospective Study on Factors Associated with Referral of Patients with Opioid Maintenance Therapy from Specialized Addictive Disorders Centers to Primary Care

Guillou-Landréat, Morgane; Levassor, Philippe; Guerlais, Marylène; Sébille, Véronique; Victorri‐Vigneau, Caroline

doi:10.3390/ijerph18115749

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…At the end of the second stage of rehabilitation physical training, Liu's overall strength quality was significantly improved. 6 The bench press score was improved to the personal all-time best score of 140 kg at the 14th week after surgery, and finally reached 150 kg; 8 super groups of pull-ups (6 for each group) and flexor arm support (8 for each group) with 32kg weight; Complete 10 times with 55 kg high turn. Hard 160 kg, nearly 2 times the weight; Box squat weight 100 kg, each group of 4, can be completed in two consecutive groups; Rome chair lifting 10 kg, complete 20, a total of 6 groups; Shoulder on the bench load hip sprint, can be in fast circumstances, load 80 kg, 12, 6 groups; Under the condition of timing, 25 barbell pieces can be completed, a total of 6 groups.…”

Section: Discussionmentioning

confidence: 93%

Athlete Tearing and Rehabilitation Characteristics

Zhao

Zhang

Kim

et al. 2021

Rev Bras Med Esporte

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Introduction: The speed and quality of functional recovery after knee cruciate ligament reconstruction directly affect the training effect and competition results of athletes. Objective: To evaluate the effect of early systematic rehabilitation after reconstruction of ligament tears in outdoor sports athletes. Methods: In this study, Liu Mou, an outstanding player of the national men's rugby team, was selected as the experimental object. A rehabilitation training program was adopted, and rehabilitation began from 2 to 5 weeks after reconstruction. Results: After the recovery of the first stage for 4 weeks, the knee extension Angle of the injured limb in Liu's sitting position reached 180 degrees. In the second stage of rehabilitation physical training, the body composition test showed that body fat decreased from 20.8% before rehabilitation to 16.3%. At the end of the third stage of physical training, he could complete the high flip. Conclusions: Through different stages of postoperative rehabilitation physical training, Liu's physical condition fully recovered to a higher level. He could then participate in normal football training and return to the game, indicating that Liu's rehabilitation training after anterior cruciate ligament reconstruction is effective. Level of evidence II; Therapeutic studies - investigation of treatment results.

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Section: Discussionmentioning

confidence: 93%

Athlete Tearing and Rehabilitation Characteristics

Zhao

Zhang

Kim

et al. 2021

Rev Bras Med Esporte

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“…The 6-month period was chosen since it is the time generally required to adapt and stabilize the dosage of OMT in the context of a global opioid use disorder treatment. In a previous study, we showed that PWUD with opioid dependence were clinically improved and stabilized in the first 6 months and 50% were referred within 280 days of entry into the center specialized in addictive disorders and the OMT introduction [ 50 ]. PWUD attending one of the 10 involved centers during the inclusion period, and corresponding to the inclusion criteria were proposed to participate to the study.…”

Section: Methodsmentioning

confidence: 99%

How do people who use drugs receiving Opioid Medication Therapy perceive their treatment ? A multicentre study

Dany¹,

Challet-Bouju

Laforgue

et al. 2022

Harm Reduct J

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Background The resurgence of heroin use and the misuse of pharmaceutical opioids are some of the reasons for a worldwide increase in opioid dependence. Opioid Medication Therapies (OMT) have amply demonstrated their efficacy. From a medical point of view, the main objectives of OMT concern medical and social outcomes, centred on risk reduction and the cessation of opioid use. But patient points of view can differ and few studies have explored opioid-dependent patient viewpoints on their OMT. This variable seems important to consider in a patient-centred approach. The aim of our study was to explore points of view of people who use drugs (PWUD) treated with OMT, in a large multicentre sample. Method A cross-sectional multicentre study explored the points of view of PWUD with Opioid Use Disorder following OMT. Data regarding the patients’ points of view were collected using a self-administered questionnaire developed by the scientific committee of the study. A descriptive analysis and an exploratory factor analysis were performed to explore the structure of items exploring patient viewpoints. Results 263 opioid dependent PWUD were included, a majority were men consuming heroin prior to being prescribed OMT. 68% were on methadone, 32% were on buprenorphine. Most PWUD identified a positive impact on their lives, with 92.8% agreeing or strongly agreeing that OMT had changed a lot of things in their lives. The exploratory factor analysis identified three factors: (F1) items related to points of views concerning the objectives and efficacy of OMT; (F2) items related to the legitimacy of OMT as a treatment compared to a drug, (F3) items related to experiences and relationships with OMT. Conclusion Patient viewpoints on efficacy were correlated with the pharmacological benefits of OMT and with the associated psychosocial measures. The implications of OMT in relationships, such as the feeling of being judged, concerned a majority. Points of view were ambivalent concerning the role of OMT as a treatment or as a drug. Involving patient points of view in therapeutic strategies decisions could help enhance positive views among PWUD on OMT and help PWUD towards their recovery. Trial registration: OPAL study was registered: (NCT01847729).

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“…The International Statistical Classification of Diseases and Related Health Problems-10 (ICD-10) criteria align in general with DSM-5 ( Hasin et al, 2013 ). OUD may develop at opioid doses employed in prescription pain management ( McAuliffe, 2013 ; Minozzi et al, 2013 ; Campbell et al, 2015 ; Degenhardt et al, 2021 ), although the burden of prescription OUD in pain patients is difficult to estimate ( Guillou-Landreat et al, 2021 ; Hasin et al, 2022 ; Sullivan and Ballantyne, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges

Salinsky,

Merritt,

Zamora

et al. 2023

Front. Pharmacol.

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Opioid misuse and opioid-involved overdose deaths are a massive public health problem involving the intertwined misuse of prescription opioids for pain management with the emergence of extremely potent fentanyl derivatives, sold as standalone products or adulterants in counterfeit prescription opioids or heroin. The incidence of repeated opioid overdose events indicates a problematic use pattern consistent with the development of the medical condition of opioid use disorder (OUD). Prescription and illicit opioids reduce pain perception by activating µ-opioid receptors (MOR) localized to the central nervous system (CNS). Dysregulation of meso-corticolimbic circuitry that subserves reward and adaptive behaviors is fundamentally involved in the progressive behavioral changes that promote and are consequent to OUD. Although opioid-induced analgesia and the rewarding effects of abused opioids are primarily mediated through MOR activation, serotonin (5-HT) is an important contributor to the pharmacology of opioid abused drugs (including heroin and prescription opioids) and OUD. There is a recent resurgence of interest into psychedelic compounds that act primarily through the 5-HT2A receptor (5-HT2AR) as a new frontier in combatting such diseases (e.g., depression, anxiety, and substance use disorders). Emerging data suggest that the MOR and 5-HT2AR crosstalk at the cellular level and within key nodes of OUD circuitry, highlighting a major opportunity for novel pharmacological intervention for OUD. There is an important gap in the preclinical profiling of psychedelic 5-HT2AR agonists in OUD models. Further, as these molecules carry risks, additional analyses of the profiles of non-hallucinogenic 5-HT2AR agonists and/or 5-HT2AR positive allosteric modulators may provide a new pathway for 5-HT2AR therapeutics. In this review, we discuss the opportunities and challenges associated with utilizing 5-HT2AR agonists as therapeutics for OUD.

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Prospective Study on Factors Associated with Referral of Patients with Opioid Maintenance Therapy from Specialized Addictive Disorders Centers to Primary Care

Cited by 4 publications

References 37 publications

Athlete Tearing and Rehabilitation Characteristics

Athlete Tearing and Rehabilitation Characteristics

How do people who use drugs receiving Opioid Medication Therapy perceive their treatment ? A multicentre study

μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges

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