Prospective study on microstructure in medication-naïve adolescents with first-episode major depressive disorder

Lee, Jong ha; Chi, Suhyuk; Ko, Minsoo; Song, Minjae; Ham, Byung Joo; Ko, Young-Hoon; Suh, Sangil; Lee, Moon Soo

doi:10.1016/j.jad.2021.06.048

Cited by 9 publications

(4 citation statements)

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“…for the updated search) of the selected full-text articles and discussion of the selected lists, no additional references were identified. Table 1 17 − 22 , 29 – 36 summarizes the final list of records included in the Systematic Review.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the included papers described incorporating motion and/or eddy current correction in their DTI pre-processing methods (13 of 14, except for Lee et al 29 ). Five studies explicitly discussed including an inhomogeneity correction.…”

Section: Resultsmentioning

confidence: 99%

“… 17 , 20 , 33 Four studies explicitly described checking the quality of the data or results (by visual inspection). 19 , 20 , 29 , 33 …”

Section: Resultsmentioning

confidence: 99%

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Systematic Review: White Matter Microstructural Organization in Adolescents With Depression

Radoeva,

Milev,

Hunt

et al. 2023

JAACAP Open

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review: White Matter Microstructural Organization in Adolescents With Depression

Radoeva,

Milev,

Hunt

et al. 2023

JAACAP Open

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“…Another interesting observation in our present study was that besides the higher depression proportion, the AG group exhibited poorer WM microstructure integrity than the AA group, mainly in CC, internal capsule, corona radiata and fornix. These WM tracts have been reported to have decreased FA in MDD (91)(92)(93)(94). Vulser et al have investigated the association of subthreshold depression with WM microstructure alterations in adolescents and found that decreased FA in the anterior body and genu of CC in adolescents with subthreshold depression (95).…”

Section: Discussionmentioning

confidence: 99%

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

et al. 2022

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BackgroundCircadian rhythm was involved in the pathogenesis of depression. The detection of circadian genes and white matter (WM) integrity achieved increasing focus for early prediction and diagnosis of major depressive disorder (MDD). This study aimed to explore the effects of PER1 gene polymorphisms (rs7221412), one of the key circadian genes, on the association between depressive level and WM microstructural integrity.Materials and methodsDiffusion tensor imaging scanning and depression assessment (Beck Depression Inventory, BDI) were performed in 77 healthy college students. Participants also underwent PER1 polymorphism detection and were divided into the AG group and AA group. The effects of PER1 genotypes on the association between the WM characteristics and BDI were analyzed using tract-based spatial statistics method.ResultsCompared with homozygous form of PER1 gene (AA), more individuals with risk allele G of PER1 gene (AG) were in depression state with BDI cutoff of 14 (χ2 = 7.37, uncorrected p = 0.007). At the level of brain imaging, the WM integrity in corpus callosum, internal capsule, corona radiata and fornix was poorer in AG group compared with AA group. Furthermore, significant interaction effects of genotype × BDI on WM characteristics were observed in several emotion-related WM tracts. To be specific, the significant relationships between BDI and WM characteristics in corpus callosum, internal capsule, corona radiata, fornix, external capsule and sagittal stratum were only found in AG group, but not in AA group.ConclusionOur findings suggested that the PER1 genotypes and emotion-related WM microstructure may provide more effective measures of depression risk at an early phase.

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Regional amplitude abnormities in the major depressive disorder: A resting-state fMRI study and support vector machine analysis

Chen

Zhao

et al. 2022

Journal of Affective Disorders

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Prospective study on microstructure in medication-naïve adolescents with first-episode major depressive disorder

Cited by 9 publications

References 50 publications

Systematic Review: White Matter Microstructural Organization in Adolescents With Depression

Systematic Review: White Matter Microstructural Organization in Adolescents With Depression

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

Regional amplitude abnormities in the major depressive disorder: A resting-state fMRI study and support vector machine analysis

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