Prospective Study on the Relationship of Obesity to Asthma Impairment and Risk

Schätz, Michael; Zeiger, Robert S.; Yang, Su-Jau; Chen, Wansu; Sajjan, Shiva; Allen‐Ramey, Felicia; Camargo, Carlos A.

doi:10.1016/j.jaip.2015.03.017

Cited by 49 publications

(42 citation statements)

References 36 publications

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“…In contrast to adult studies (31–33), our findings suggest that obesity is not a major risk factor for uncontrolled asthma or more severe asthma, but that atopy is a clear risk factor for asthma severity, in low-income, minority pediatric populations. We did not, however, find associations between atopy and asthma symptoms.…”

Section: Discussioncontrasting

confidence: 99%

Atopy, but not obesity is associated with asthma severity among children with persistent asthma

Phipatanakul

Perzanowski

et al. 2016

Journal of Asthma

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Background and Objective Obesity is associated with an increased risk of asthma in children. Atopic sensitization is a major risk factor for asthma including severe asthma in children. It is unclear if obesity is associated with worse asthma control or severity in children and how its effects compare to atopy. We sought to examine relationships of weight status and atopy to asthma control and severity among a population of predominantly low income, minority children and adolescents with persistent asthma. Methods A cross-sectional analysis of 832 children and adolescents, age range 5–17 years, with persistent asthma was performed. Clinical assessments included asthma questionnaires of symptoms, asthma severity score, health care utilization and medication treatment step, lung function testing, and skin prick testing as well as measures of adiposity. Data were collected between December 2010 and August 2014 from Johns Hopkins Hospital in Baltimore, MD and Children’s Hospital of Boston, MA. Results Obesity was not associated with worse asthma control or severity in this group of predominantly low income, minority children and adolescents with persistent asthma. However, a greater degree of atopy was associated with lower lung function, higher asthma severity score, and higher medication treatment step. Conclusion Atopy may be a more important risk factor for asthma severity than obesity among low-income minority children and adolescents with persistent asthma living in Northeastern cities in the United States.

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Section: Discussioncontrasting

confidence: 99%

Atopy, but not obesity is associated with asthma severity among children with persistent asthma

Phipatanakul

Perzanowski

et al. 2016

Journal of Asthma

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“…In our population of asthmatics who required any hospital readmission, more than 71% were obese or overweight, but this is not associated with the incidence of hospital readmissions. Our results are in agreement with the other authors who did not observe a relationship between obesity and exacerbations or with the control of the asthma [8,16,21,[29][30][31], although it was different from other studies where we showed a poorer control of asthma or increase in the incidence of the exacerbations with obesity [13][14][15]19,20,[32][33][34][35][36].…”

Section: Discussionsupporting

confidence: 80%

Obesity Does Not Increase the Risk of Asthma Readmissions

Barcala

Nieto‐Fontarigo

Lourido-Cebreiro

et al. 2020

JCM

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The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively performed on all hospital admissions of adult patients due to asthma exacerbation occurring in our hospital for 11 years. All those cases with asthma as the first diagnosis in the discharge report were included, or those with asthma as the second diagnosis provided when the first diagnosis was respiratory infection or respiratory failure. Only the first hospital admission of each patient was included in this study. The Odds Ratios of a higher incidence of early/late readmissions due to asthma exacerbation were calculated using a binary logistic regression, using the body mass index (BMI) as independent variable, adjusted for all the variables included in the study. The study included 809 patients with a mean age of 55.6 years, and 65.2% were female. The majority (71.4%) were obese or overweight. No significant relationship was observed in the univariate or multivariate analyses between overweight or obesity and the early or late hospital readmissions due to asthma. Therefore, obesity does not seem to be a determining factor in the risk of asthma exacerbations.

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“…There is some data to suggest overweight and obesity is associated with worsening asthma in nonpregnant adults [27]. Overweight or obesity may both impact on the airway via similar mechanisms that include systemic inflammation, airway hyperresponsiveness and the mechanical impact of weight itself on thoracic cavity function [28].…”

Section: Discussionmentioning

confidence: 99%

Patterns, predictors and outcomes of asthma control and exacerbations during pregnancy: a prospective cohort study

et al. 2016

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There exists a paucity of data for socially disadvantaged populations describing patterns and predictors of asthma control status and exacerbations during pregnancy, and their relationship to adverse perinatal outcomes.Asthmatic women (n=189) were followed prospectively during pregnancy, with visits at 12, 20, 28 and 36 weeks gestation. Data on loss of control, recurrent uncontrolled asthma and moderate/severe exacerbations were collected at each visit and their relationship to perinatal outcomes examined following stratification for fetal sex.50% of asthmatic women experienced a loss of control or moderate/severe exacerbation during pregnancy, with 22% of women experiencing a moderate/severe exacerbation. Factors associated with an increased risk of women experiencing recurrent uncontrolled asthma during pregnancy included smoking (relative risk 2.92, 95% CI 1.53–5.58), inhaled corticosteroid use at the beginning of pregnancy (relative risk 2.40, 95% CI 1.25–4.60) and increasing maternal age (relative risk 1.06, 95% CI 1.01–1.11). No factors were associated with moderate/severe exacerbations. Asthma control rather than exacerbations during pregnancy appeared to be most strongly correlated with perinatal outcomes. Following stratification by fetal sex, the presence of recurrent uncontrolled asthma was associated with an increased risk of being small for gestational age in women pregnant with females (33.3% versus 9.5%; p=0.018). In contrast, there was a nonsignificant increased risk of preterm birth in women with recurrent uncontrolled asthma that were pregnant with males (25.0% versus 11.8%; p=0.201)These results suggest that the key to improving perinatal outcomes lies in improving asthma control as early as possible in pregnancy and monitoring throughout pregnancy, rather than focusing on preventing exacerbations alone.

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Prospective Study on the Relationship of Obesity to Asthma Impairment and Risk

Cited by 49 publications

References 36 publications

Atopy, but not obesity is associated with asthma severity among children with persistent asthma

Atopy, but not obesity is associated with asthma severity among children with persistent asthma

Obesity Does Not Increase the Risk of Asthma Readmissions

Patterns, predictors and outcomes of asthma control and exacerbations during pregnancy: a prospective cohort study

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