Prospective survey of neoplastic and non-neoplastic uterine disorders in 116 domestic rabbits (Oryctolagus cuniculus)

Mäkitaipale, Johanna; Airas, Niina; Engblom, Sanna; Lindén, Jere

doi:10.1053/j.jepm.2022.01.001

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…O diagnóstico utilizado para hiperplasia endometrial cística é a ultrassonografia (SAITO et al, 2002;WALTER et al, 2010;SLADAKOVIC et al, 2015;MÄKITAIPALE et al, 2022). Em alguns casos é possível observar a presença de massas esféricas irregulares, podendo ser associadas à presença de neoplasias.…”

Section: Resultados E Discussõesunclassified

“…No presente caso, foi realizado exame ultrassonográfico para confirmar a origem da secreção sanguinolenta, sendo possível diagnosticar a hiperplasia endometrial, porém não foi possível observar a presença de massas no endométrio. Quanto ao diagnóstico de leiomioma, deve ser realizada a análise histopatológica para confirmar suas características microscópicas, não sendo recomendado utilizar somente a palpação abdominal e o exame radiográfico como método de diagnóstico definitivo (WALTER et al, 2010;MÄKITAIPALE et al, 2022).…”

Section: Resultados E Discussõesunclassified

“…A ocorrência simultânea dessas duas enfermidades ainda não é comprovada precisamente, entretanto, um estudo realizado por Asakawa et al, (2008), demonstrou que aproximadamente 80% das amostras coletadas com hiperplasia endometrial cística eram hormônio-dependente; além da interferência da idade nos achados científicos de Saito et al (2002), Walter et al (2010), Quevedo et al (2015), Mäkitaipale et al (2022) e Shiga et al (2022) que demonstraram a prevalência dessas patologias em animais mais velhos (entre quatro a sete anos). Contudo, o animal do presente caso é jovem, possuindo menos de dois anos, contradizendo os relatos.…”

Section: Resultados E Discussõesunclassified

“…Os animais acometidos com o leiomioma e hiperplasia endometrial cística constantemente apresentam sinais clínicos de sangramento vulvar, além de outros sinais como aumento do abdomen, desconforto abdominal, desordem mamária, letargia e anorexia. Contudo, alguns animais ainda podem se apresentar de forma assintomática e não serem identificados (SAITO et al, 2002;RAIMUNDO, 2022;KOJIMOTO et al, 2021;QUESENBERRY et al, 2021;MÄKITAIPALE et al, 2022) (2002), os dados mostraram que 28,79% (14/47) dos animais estavam acometidos com HEC, e em outro estudo feito por Walter et al (2010) 40,68% (24/59) dos animais possuíam a mesma enfermidade. Em humanos e cães, os leiomiomas são as neoplasias diagnosticadas com maior frequência, porém em coelhos a ocorrência é menos frequente (RICHTER et al, 2006;SOUZA et al, 2008;CHEN;NOVO, 2018;LIMA;ANDREUSSI, 2019;SILVESTRE, 2019).…”

Section: Resultados E Discussõesunclassified

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LEIOMIOMA UTERINO ASSOCIADO A HIPERPLASIA ENDOMETRIAL CÍSTICA DIFUSA EM COELHO DOMÉSTICO (Oryctolagus cuniculus) – RELATO DE CASO

Lima,

Malta,

Pedri

et al. 2023

ENCIBIO

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Section: Resultados E Discussõesunclassified

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LEIOMIOMA UTERINO ASSOCIADO A HIPERPLASIA ENDOMETRIAL CÍSTICA DIFUSA EM COELHO DOMÉSTICO (Oryctolagus cuniculus) – RELATO DE CASO

Lima,

Malta,

Pedri

et al. 2023

ENCIBIO

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Neoplastic and non-neoplastic lesions in biopsy samples from pet rabbits in Hong Kong: a retrospective analysis, 2019-2022

Hill,

Tse,

Ferguson

et al. 2024

J VET Diagn Invest

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Rabbits are popular pets in the urban environment of Hong Kong, ranking third behind cats and dogs. Here we describe the frequency of neoplastic and non-neoplastic lesions in biopsies from pet rabbits submitted to the CityU Veterinary Diagnostic Laboratory between 2019 and 2022, comprising 247 tissue samples from 243 rabbits collected by veterinarians in 19 veterinary clinics. Among the 243 rabbits, there were 128 females (65 spayed), 114 males (54 castrated); sex information was not provided for 1 rabbit. The rabbit breeds included 45 Lionhead, 35 Dwarf, 14 Lop, 11 Dwarf Lop, 5 French Lop, 3 Angora, 2 Dutch, 2 Holland Lop, and 1 each of Netherland Dwarf, Velveteen, Mini Lop, and New Zealand White. The mean ages of rabbits with neoplastic and non-neoplastic lesions were 7.1 and 5.7 y, respectively. The most common neoplastic lesions were adenocarcinoma (26.4%), trichoblastoma (21.4%), sarcoma (9.4%), and thymoma (8.2%). The most common non-neoplastic lesion was uterine cystic endometrial hyperplasia (14.8%), followed by dermal abscess formation in the ventral abdomen or skin of the head (12.5%). Although a broad spectrum of other lesions was described, our findings in biopsies from pet rabbits in Hong Kong are consistent with those in other jurisdictions.

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Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy

Vaccaro,

Navas,

Ercolano

et al. 2024

Animals

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Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. This study evaluates (1) the expression of COX-2 in rabbit uterine adenocarcinomas, (2) the correlation between immunophenotypic expression and histopathological changes, and (3) the post-surgery response to therapy with COX-2 inhibitors. Forty rabbit uteri were divided into three groups: neoplastic, hyperplastic, and normal endometrium. A histological and immunohistochemical score was applied to investigate the tumor’s grade and the COX-2 expression. By histological evaluation, 30 cases of endometrial adenocarcinoma, 5 cases of endometrial hyperplasia and 5 normal endometria were found. Of the six cases of endometrial adenocarcinoma with follow-up available, four received a post-surgical treatment with meloxicam and two were treated by surgery alone. The survival time of the animals treated with meloxicam was longer than that observed in the untreated animals. A statistically significant difference in COX-2 IHS was observed between non-neoplastic endometrium and adenocarcinoma. The progressive increase in COX-2 expression from normal epithelium to carcinoma suggests that upregulation of COX-2 expression may play a role in tumor initiation and progression. Our findings suggest the possible use of COX-2 inhibitors in treating uterine adenocarcinoma in rabbits. Further study will be needed to confirm this hypothesis.

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Prospective survey of neoplastic and non-neoplastic uterine disorders in 116 domestic rabbits (Oryctolagus cuniculus)

Cited by 3 publications

References 24 publications

LEIOMIOMA UTERINO ASSOCIADO A HIPERPLASIA ENDOMETRIAL CÍSTICA DIFUSA EM COELHO DOMÉSTICO (Oryctolagus cuniculus) – RELATO DE CASO

LEIOMIOMA UTERINO ASSOCIADO A HIPERPLASIA ENDOMETRIAL CÍSTICA DIFUSA EM COELHO DOMÉSTICO (Oryctolagus cuniculus) – RELATO DE CASO

Neoplastic and non-neoplastic lesions in biopsy samples from pet rabbits in Hong Kong: a retrospective analysis, 2019-2022

Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy

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