Prospective trial of Adipose-Derived Regenerative Cell (ADRC)-enriched fat grafting for partial mastectomy defects: The RESTORE-2 trial

Pérez-Cano, Rosa; Vranckx, Jan; Lasso, José M.; Calabrese, Claudio; Merck, Belén; Milstein, Alexander M.; Sassoon, Elaine M.; Delay, E.; Weiler-Mithoff, Eva

doi:10.1016/j.ejso.2012.02.178

Cited by 178 publications

(155 citation statements)

References 19 publications

Supporting

Mentioning

147

Contrasting

Unclassified

Order By: Relevance

“…A fat graft specimen contains mature adipocytes and preadipocytes, also known as adipose derived stem cells (ASC) 56,58,59 . ASCs have considerable angiogenic and antiapoptotic features and constitute 10% of the cell population, however graft survival is largely dependent on them given their huge proliferative contribution 14,40,[57][58][59] .…”

Section: Commented [Re8]: Are These Figure Pooled Results Frommentioning

confidence: 99%

A Case-Controlled Study of the Oncologic Safety of Fat Grafting

Gale

Rakha

Ball

et al. 2015

Plastic and Reconstructive Surgery

110

View full text Add to dashboard Cite

show abstract

Section: Commented [Re8]: Are These Figure Pooled Results Frommentioning

confidence: 99%

A Case-Controlled Study of the Oncologic Safety of Fat Grafting

Gale

Rakha

Ball

et al. 2015

Plastic and Reconstructive Surgery

110

View full text Add to dashboard Cite

show abstract

“…29 cases resulted in improved and 35 cases sustained unchanged by LENT-SOMA scale for breast radiotherapy morphology. 50 out of 67 reported satisfactory in quality of life scale by SF-36v2 and there was an improvement in blinded MRI assessment in 54 out of 65 cases (18). ADRCs mixed with fat tissue have potential in cell therapy for radiation injury due to increasing neovascularization and retention of the fat property.…”

Section: Discussionmentioning

confidence: 99%

Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries

Akita

Yoshimoto

Ohtsuru

et al. 2012

Radiation Protection Dosimetry

View full text Add to dashboard Cite

Abstract:Effective therapy for chronic radiation injuries such as ulcer, prone to infection and stiffness are expected. As the therapeutic radiation is often involve wider and deeper tissues and often require extensive debridement and reconstruction, which are not sometimes appropriate for elderly and compromised hosts.Autologous adipose-derived regenerative cells (ADRCs) are highly yielding form relatively elderly aged consecutive 10 cases, 63.6 ± 14.9 years (52 to 89 years), with mean radiation dose of 75.0 ± 35.4 Gy (50 to 120 Gy) were included with at least 10-month follow-ups. Minimal debridement and ADRC injection in the wound bed and margin along with injection of mixture of fat and ADRCs in the periphery were tested for efficacy and regenerated tissue quality by clinically as well as imaging by CT and MRI.Uncultured ADRCs of 1.6 ± 1.3 × 10 7 cells were obtained. All cases healed uneventfully after 6.6 ± 3.2 weeks (2 to 10 weeks) post-operatively. The done site morbidity was negligible and no major complications such as paralysis or massive hematoma. The regenerated tissue quality was significantly superior to the pre-operatively and the mixture of fat and ADRCs connected to the intact tissue demonstrated very soft and pliable quality. Mean follow-up at 1.9 ± 0.8 years (0.9 to 2.9 years) revealed no recurrence or new ulceration after treatment. Thus, the ADRC s treatment for decades-long radiation injuries is effective, safe and improves the quality of wounds.

show abstract

“…There are only limited data regarding the long-term oncological safety of lipofilling; however, one retrospective review did show that after a mean follow-up period of >40 months, fat grafting did not affect local tumour recurrence or survival (125). The most common complications with autologous fat grafting include fat necrosis (3.6%), oil cysts (1.8%) and infection (0.9%) (126)(127)(128). Complications appear to be higher with implant-based reconstructions compared with autologous flap reconstructions (129).…”

Section: What Is the Role Of Autologous Fat Grafting As An Adjuncmentioning

confidence: 99%