Latin America shows high plant biodiversity, this diversity is also reflected in all Colombian bioregions, supported by the varied topography and climates. Despite these rich natural resources, scientific understanding of Colombia's flora remains incomplete. The present study addresses the need to discuss the scientific publications around Colombian natural products derived from plants, specifically to the Coffee region. This is part of a larger initiative to explore the information available and highlight the research conducted so far. Consequently, Colombian authorities have recently launched programs to better study and utilize this biodiversity. Research related to natural products in Colombia is distributed across several information sources, making it challenging to recognize and compile. Additionally, studies focused on the structural elucidation of compounds are recent and have been reported only in the last twenty years. Likewise, it is not very abundant according to the results found. This study aims to review the current state of research on natural products derived from plants in Colombia's coffee region. To achieve this, we conducted a bibliometric analysis focusing on literature in English publications from the last few years retrieved from Web of Science (WoS) and Scopus. The analysis included identifying the most productive authors and key research topics with Bibliometrix. We also examined the impact and visibility of the publications by analyzing the H-index and quartile rankings of the journals where the research was published. Additionally, keyword analysis was performed using VOSviewer to visualize the main themes and trends in the field. This comprehensive review provides insights into the development and direction of research on natural products derived from plants in Colombia's Coffee region, highlighting the most influential studies and emerging areas of interest.