Prospective Use of Probiotics to Maintain Astronaut Health during Spaceflight

Bharindwal, Sahaj; Goswami, Nupur; Jha, Pamela; Pandey, S.; Jobby, Renitta

doi:10.3390/life13030727

Cited by 9 publications

(4 citation statements)

References 100 publications

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“…Exploring the microbiome in space has the potential to pave the way for novel therapies and remedies for various health ailments. For example, researchers are exploring the use of probiotics and other microbiome-based therapies to prevent or treat conditions such as bone loss and immune system dysfunction that can occur during space travel ( Turroni et al, 2020 ; Bharindwal et al, 2023 ).…”

Section: Why Studying the Human Microbiome In Space Is Of Crucial Imp...mentioning

confidence: 99%

How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond

Mortazavi,

Said-Salman,

Mortazavi

et al. 2024

Front. Microbiol.

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The ability of human cells to adapt to space radiation is essential for the well-being of astronauts during long-distance space expeditions, such as voyages to Mars or other deep space destinations. However, the adaptation of the microbiomes should not be overlooked. Microorganisms inside an astronaut’s body, or inside the space station or other spacecraft, will also be exposed to radiation, which may induce resistance to antibiotics, UV, heat, desiccation, and other life-threatening factors. Therefore, it is essential to consider the potential effects of radiation not only on humans but also on their microbiomes to develop effective risk reduction strategies for space missions. Studying the human microbiome in space missions can have several potential benefits, including but not limited to a better understanding of the major effects space travel has on human health, developing new technologies for monitoring health and developing new radiation therapies and treatments. While radioadaptive response in astronauts’ cells can lead to resistance against high levels of space radiation, radioadaptive response in their microbiome can lead to resistance against UV, heat, desiccation, antibiotics, and radiation. As astronauts and their microbiomes compete to adapt to the space environment. The microorganisms may emerge as the winners, leading to life-threatening situations due to lethal infections. Therefore, understanding the magnitude of the adaptation of microorganisms before launching a space mission is crucial to be able to develop effective strategies to mitigate the risks associated with radiation exposure. Ensuring the safety and well-being of astronauts during long-duration space missions and minimizing the risks linked with radiation exposure can be achieved by adopting this approach.

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Section: Why Studying the Human Microbiome In Space Is Of Crucial Imp...mentioning

confidence: 99%

How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond

Mortazavi,

Said-Salman,

Mortazavi

et al. 2024

Front. Microbiol.

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“…Furthermore, it has been proven that the space flights conditions had an impact on the overall microbiome of astronauts and the host-microbe interactions ( Tesei et al, 2022 ). Probiotics have been suggested as promising countermeasures for health issues during long-haul space flights and we propose that this could be applied for oral diseases and infections ( Bharindwal et al, 2023 ). Further studies are deemed necessary to validate this proposal.…”

Section: The Effect Of Space Flights On the Oral Mucosamentioning

confidence: 99%

Considerations for oral and dental tissues in holistic care during long-haul space flights

Bakr,

Caswell,

Hussein

et al. 2024

Front. Physiol.

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The health of astronauts during and after the return from long-haul space missions is paramount. There is plethora of research in the literature about the medical side of astronauts’ health, however, the dental and oral health of the space crew seem to be overlooked with limited information in the literature about the effects of the space environment and microgravity on the oral and dental tissues. In this article, we shed some light on the latest available research related to space dentistry and provide some hypotheses that could guide the directions of future research and help maintain the oral health of space crews. We also promote for the importance of regenerative medicine and dentistry as well highlight the opportunities available in the expanding field of bioprinting/biomanufacturing through utilizing the effects of microgravity on stem cells culture techniques. Finally, we provide recommendations for adopting a multidisciplinary approach for oral healthcare during long-haul space flights.

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“…Additionally, weightlessness causes hormonal homeostasis disorders such as decreased testosterone levels in men 6 . Additionally, disorders of the gut microflora can affect gastrointestinal function 7 , including sleep problems 8 . Moreover, psychological changes, such as feelings of social isolation, decreased motivation and mood, and an increased risk of psychiatric disorders, such as depression and anxiety, are also associated risks 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Numerical analysis of blood flow in the abdominal aorta under simulated weightlessness and earth conditions

Żyłka,

Górski,

Żyłka

et al. 2024

Sci Rep

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Blood flow through the abdominal aorta and iliac arteries is a crucial area of research in hemodynamics and cardiovascular diseases. To get in to the problem, this study presents detailed analyses of blood flow through the abdominal aorta, together with left and right iliac arteries, under Earth gravity and weightless conditions, both at the rest stage, and during physical activity. The analysis were conducted using ANSYS Fluent software. The results indicate, that there is significantly less variation in blood flow velocity under weightless conditions, compared to measurement taken under Earth Gravity conditions. Study presents, that the maximum and minimum blood flow velocities decrease and increase, respectively, under weightless conditions. Our model for the left iliac artery revealed higher blood flow velocities during the peak of the systolic phase (systole) and lower velocities during the early diastolic phase (diastole). Furthermore, we analyzed the shear stress of the vessel wall and the mean shear stress over time. Additionally, the distribution of oscillatory shear rate, commonly used in hemodynamic analyses, was examined to assess the effects of blood flow on the blood vessels. Countermeasures to mitigate the negative effects of weightlessness on astronauts health are discussed, including exercises performed on the equipment aboard the space station. These exercises aim to maintain optimal blood flow, prevent the formation of atherosclerotic plaques, and reduce the risk of cardiovascular complications.

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Prospective Use of Probiotics to Maintain Astronaut Health during Spaceflight

Cited by 9 publications

References 100 publications

How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond

How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond

Considerations for oral and dental tissues in holistic care during long-haul space flights

Numerical analysis of blood flow in the abdominal aorta under simulated weightlessness and earth conditions

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