Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements Using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions

Vörös, Szilárd; Rinehart, Sarah; Qian, Zhen; Vázquez, Gustavo; Anderson, Hunt; Murrieta, Laura; Wilmer, Charles; Carlson, Harold; Taylor, Kenneth W.; Ballard, William L.; Karmpaliotis, Dimitri; Kalynych, Anna; Brown, Charles L.

doi:10.1016/j.jcin.2010.10.008

Cited by 179 publications

(66 citation statements)

References 19 publications

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“…In addition, the assessment of the entire coronary tree requires a 3-vessel catheter-based interrogation, which may involve additional risks for the patients [21] . In this regard, CCTA would be a valuable non-invasive alternative to IVUS, especially in light of the good correlation of the 2 techniques in terms of plaque composition assessment [14,32,38,[47][48][49] .…”

Section: Virtual Histology-intravascular Ultrasoundmentioning

confidence: 99%

Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers

Gitsioudis

Katus

Korosoglou

2014

WJC

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Chronic inflammatory mechanisms in the arterial wall lead to atherosclerosis, and include endothelial cell damage, inflammation, apoptosis, lipoprotein deposition, calcification and fibrosis. Cardiac computed tomography angiography (CCTA) has been shown to be a promising tool for non-invasive assessment of theses specific compositional and structural changes in coronary arteries. This review focuses on the technical background of CCTA-based quantitative plaque characterization. Furthermore, we discuss the available evidence for CCTA-based plaque characterization and the potential role of CCTA for risk stratification of patients with coronary artery disease.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Atherosclerotic plaque composition; Quantification analysis; Multi-slice cardiac computed tomography; Biomarkers Core tip: This review gives an overview of the current status of noninvasive assessment of coronary artery disease (CAD) and the ability of cardiac computed tomography angiography (CCTA) and cardiac biomarkers for the diagnostic classification and risk stratification of patients with suspected and known CAD. Since all techniques described herein are available in the clinical routine and are associated with an acceptable time spent the translation to the clinical realm appears promising. Focusing on CCTA-based quantitative plaque characterization we herein present the (1) available evidence; (2) comparison with other techniques of plaque characterization; and (3) the value of "bio-imaging" for the risk stratification of patients with CAD.Gitsioudis G, Katus HA, Korosoglou G. Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers.

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Section: Virtual Histology-intravascular Ultrasoundmentioning

confidence: 99%

Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers

Gitsioudis

Katus

Korosoglou

2014

WJC

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“…58 When compared with VH-IVUS, fibrous plaques display high attenuation on CT, whereas low attenuation occurs in relation to necrotic core and fibrofatty tissue. 59 Good correlations have also been shown between high-risk CT features and TCFA on OCT, 60 and CT-derived plaque burden to cholesterol deposition on NIRS. 61 On the basis of IVUS studies, Hounsfield unit <30 on CCTA has been proposed as a cutoff for identification of lipid rich plaque, with 30 to 150 Hounsfield unit for fibrous and >220 Hounsfield unit calcific.…”

Section: Ct-derived Plaque Morphologymentioning

confidence: 96%

Imaging of atherosclerosis

Takx

Partovi

Ghoshhajra

2015

Int J Cardiovasc Imaging

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Advances in atherosclerosis imaging technology and research have provided a range of diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular imaging methods additionally promise great scientific and translational applications beyond this quest. When combined with conventional anatomic-and hemodynamic-based assessments of disease severity, cross-sectional multimodal imaging incorporating molecular probes and other novel noninvasive techniques can add detailed interrogation of plaque composition, activity, and overall disease burden. In the catheterization laboratory, intravascular imaging provides unparalleled access to the world beneath the plaque surface, allowing tissue characterization and measurement of cap thickness with micrometer spatial resolution. Atherosclerosis imaging captures key data that reveal snapshots into underlying biology, which can test our understanding of fundamental research questions and shape our approach toward patient management. Imaging can also be used to quantify response to therapeutic interventions and ultimately help predict cardiovascular risk. Although there are undeniable barriers to clinical translation, many of these hold-ups might soon be surpassed by rapidly evolving innovations to improve image acquisition, coregistration, motion correction, and reduce radiation exposure. This article provides a comprehensive review of current and experimental atherosclerosis imaging methods and their uses in research and potential for translation to the clinic. (Circ Res. 2016;118:750-769.

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“…16,17 There is a growing evidence to show that CCTA has good correlation with IVUS in the quantitative plaque analysis. [18][19][20][21][22] However, limited research is conducted with regard to the inter/intra-reader and interscanner agreement or variability of CCTA in the quantitative assessment of coronary plaques. This has been addressed in a recently published study which is discussed in the following sections.…”

Section: 15mentioning

confidence: 99%

Quantitative Assessment of Coronary Plaques by Coronary CT Angiography: High Inter-Reader and Intra-Reader Agreement is Achieved but Inter-Scanner Variability should not be Ignored

Sun¹

2017

Heart Res Open J

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CitationSun Z. Quantitative assessment of coronary plaques by coronary CT angiography: High inter-reader and intra-reader agreement is achieved but inter-scanner variability should not be ignored. Heart Res Open J. 2017; 4(1): e1-e5. doi: 10.17140/HROJ-4-e007 ABSTRACTThis editorial discusses a recent paper published in the December issue of Radiology 2016 on the quantitative assessment of coronary plaques by coronary computed tomography (CT) angiography. Three main findings are discussed in the editorial: First, coronary CT angiography is an accurate imaging modality for analysis of plaque volume as well as monitoring volume change, with excellent inter-and intra-reader agreement with use of the state-of-the-art CT scanners. Second, the reliability of coronary CT angiography is noticed for low scan variability when plaque volume assessment is performed with the same vendor, but with high variability of nearly 30% when assessment is conducted with different vendors at baseline and follow-up scans. Finally, a large sample size is required to assess non-calcified plaques, in particular with use of different vendors.KEY WORDS: Coronary artery disease; Coronary CT angiography; Coronary plaque; Volume measurement; Variability.Coronary CT angiography (CCTA) is currently a widely used imaging modality for the diagnostic assessment of patients with suspected coronary artery disease (CAD) with high diagnostic accuracy reported in the literature.1-5 Rapid technological developments on cardiac CT imaging have occurred over the last decade which have led to the development and improvement of diagnostic spectrum of CCTA in the quantitative analysis of coronary plaques, in addition to the diagnostic value of coronary artery stenosis. These included characterization of plaque features and the corresponding clinical outcomes such as prediction of major adverse cardiac events, in addition to the routine assessment of coronary lumen stenosis. [6][7][8][9] Detection of plaque components, in particular, differentiation of non-calcified (vulnerable) from calcified (stable) plaques is more significant than detection of lumen stenosis because close association has been reported between plaque composition and myocardial ischemia and development of adverse cardiac events.10-13 Therefore, the current research direction of CCTA has primarily focused on the quantitative assessment of plaque features instead of coronary lumen analysis because the degree of lumen stenosis is not always associated with myocardial ischemic changes. 14,15Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are two imaging modalities which allow excellent plaque characterization by providing intravascular views of plaque components, however, both are invasive, thus, they are not commonly performed in clinical practice. As a less invasive modality with widespread use in daily practice, CCTA is able to provide quantitative assessment of plaque morphology and components which add

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Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements Using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions

Cited by 179 publications

References 19 publications

Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers

Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers

Imaging of atherosclerosis

Quantitative Assessment of Coronary Plaques by Coronary CT Angiography: High Inter-Reader and Intra-Reader Agreement is Achieved but Inter-Scanner Variability should not be Ignored

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