Prospective Validation of the Association of Local Tumor Stage and Grade as a Predictive Factor for Occult Lymph Node Micrometastasis in Patients With Penile Carcinoma and Clinically Negative Inguinal Lymph Nodes

Solsona, E.; Iborra, I.; Rubio, José; Casanova, J.; Ricós, J.V.; Calabuig, C

doi:10.1016/s0022-5347(05)66337-9

Cited by 180 publications

(60 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2006). Risk groups systems combine histological grade with tumor extension to estimate the likelihood of inguinal nodal involvement (Solsona et al 2001, 2004; Hungerhuber et al 2006; Ornellas et al 2008). The combination of histological grade, anatomical level of invasion and presence of perineural invasion was found to be strongly related to nodal involvement and cancer-specific survival (Chaux et al.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis

Chaux

2015

SpringerPlus

View full text Add to dashboard Cite

PurposeTo report the clinicopathologic and outcome features of superficial high-grade and deep low-grade penile squamous cell carcinomas.MethodsFrom a retrospectively-collected series of patients with penile cancer we identified 41 cases corresponding to 12 superficial high-grade tumors and 29 deep low-grade tumors. As outcomes we evaluated inguinal lymph node status, presence of tumor relapse, final nodal status, and cancer-specific death. Follow-up ranged from 0.8 to 386.7 months (mean 152.5 months, median 157.3 months).ResultsClinicopathologic features were similar between superficial high-grade and deep low-grade tumors, except for a tendency (Fisher’s exact ) of the former to include tumors with a verruciform pattern of growth. A significantly higher proportion of inguinal lymph node metastasis was found in superficial high-grade tumors compared to deep low-grade tumors [4/5 (80%) vs. 1/5 (20%) respectively, Fisher’s exact ]. No significant differences were found regarding tumor relapse (Fisher’s exact ), final nodal status (Mantel-Cox’s ), or cancer-related death (Mantel-Cox’s ).ConclusionsPatients with superficial high-grade tumors had a significantly higher proportion of inguinal lymph node metastasis compared to patients with deep low-grade tumors. On this regard, prophylactic inguinal lymphadenectomy might be indicated in cases of superficial tumors with high-grade histology while in deeply invasive low-grade penile carcinomas a more conservative approach may be considered.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis

Chaux

2015

SpringerPlus

View full text Add to dashboard Cite

show abstract

“…4,25 These factors can then further define patients into low-, intermediate-, and high-risk groups for lymph node metastasis. 18,60,61 The European Association of Urology determined risk stratification groups for patients with nonpalpable ILNs, and validated this in both univariate and multivariate analyses of prognostic factors. Patients can be stratified according to stage and/or grade into risk groups based on the likelihood of harboring occult node-positive disease, with the low-risk group defined as patients with Tis, Ta,G1–2 or T1,G1; the intermediate-risk group as those with T1,G2; and the high-risk group as those with T2 or G3.…”

Section: Management Of Regional Lymph Nodesmentioning

confidence: 99%

“…Patients can be stratified according to stage and/or grade into risk groups based on the likelihood of harboring occult node-positive disease, with the low-risk group defined as patients with Tis, Ta,G1–2 or T1,G1; the intermediate-risk group as those with T1,G2; and the high-risk group as those with T2 or G3. 51,60 …”

Section: Management Of Regional Lymph Nodesmentioning

confidence: 99%

“…60,93 For patients in the high-risk group (T2 or G3) and intermediate-risk patients with lymphovascular invasion, a modified or radical inguinal lymphadenectomy is strongly recommended, because occult metastatic disease ranges between 68% and 73%. 46,60,93 If positive nodes are present on the frozen section, then a superficial and deep inguinal lymphadenectomy should be performed (with consideration of a PLND).…”

Section: Management Of Regional Lymph Nodesmentioning

confidence: 99%

See 1 more Smart Citation

Penile Cancer

Clark¹,

Spiess²,

Agarwal³

et al. 2013

J Natl Compr Canc Netw

159

View full text Add to dashboard Cite

Squamous cell carcinoma of the penis represents approximately 0.5% of all cancers among men in the United States and other developed countries. Although rare, it is associated with significant disfigurement, and only half of the patients survive beyond 5 years. Proper evaluation of both the primary lesion and lymph nodes is critical, because nodal involvement is the most important factor of survival. The NCCN Clinical Practice Guidelines in Oncology for Penile Cancer provide recommendations on the diagnosis and management of this devastating disease based on evidence and expert consensus.

show abstract

“…Potential prognostic markers are usually validated using prospective studies for clinical application [25]. Tissue or blood specimens are typically accumulated on a long-term basis until there are clear objectives for study.…”

Section: Introductionmentioning

confidence: 99%

Deconvolution of the Gene Expression Profiles of Valuable Banked Blood Specimens for Studying the Prognostic Values of Altered Peripheral Immune Cell Proportions in Cancer Patients

Dong

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundThe altered composition of immune cells in peripheral blood has been reported to be associated with cancer patient survival. However, analysis of the composition of peripheral immune cells are often limited in retrospective survival studies employing banked blood specimens with long-term follow-up because the application of flow cytometry to such specimens is problematic. The aim of this study was to demonstrate the feasibility of deconvolving blood-based gene expression profiles (GEPs) to estimate the proportions of immune cells and determine their prognostic values for cancer patients.Methods and ResultsHere, using GEPs from peripheral blood mononuclear cells (PBMC) of 108 non-small cell lung cancer (NSCLC) patients, we deconvolved the immune cell proportions and analyzed their association with patient survival. Univariate Kaplan-Meier analysis showed that a low proportion of T cells was significantly associated with poor patient survival, as was the proportion of T helper cells; however, only the proportion of T cells was independently prognostic for patients by a multivariate Cox regression analysis (hazard ratio = 2.23; 95% CI, 1.01–4.92; p = .048). Considering that altered peripheral blood compositions can reflect altered immune responses within the tumor microenvironment, based on a tissue-based GEPs of NSCLC patients, we demonstrated a significant association between poor patient survival and the low level of antigen presentation, which play a critical role in T cell proliferation.ConclusionsThese results demonstrate that it is feasible to deconvolve GEPs from banked blood specimens for retrospective survival analysis of alterations of immune cell composition, and suggest the proportion of T cells in PBMC which might reflect the antigen presentation level within the tumor microenvironment can be a prognostic marker for NSCLC patients.

show abstract

Prospective Validation of the Association of Local Tumor Stage and Grade as a Predictive Factor for Occult Lymph Node Micrometastasis in Patients With Penile Carcinoma and Clinically Negative Inguinal Lymph Nodes

Cited by 180 publications

References 19 publications

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis

Penile Cancer

Deconvolution of the Gene Expression Profiles of Valuable Banked Blood Specimens for Studying the Prognostic Values of Altered Peripheral Immune Cell Proportions in Cancer Patients

Contact Info

Product

Resources

About