Prospective validation of the Chinese University Prognostic Index and comparison with other staging systems for hepatocellular carcinoma in an Asian population

Abstract

We have validated CUPI in a population composed of predominant HBV-related HCC. CUPI is an appropriate staging system for HBV-related HCC. In patients with advanced HCC, both CUPI and CLIP offer good risk stratification.

A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma

“…Patients who had stage III and stage IV disease also were grouped for evaluation because of the similar outcomes in this group, as demonstrated in a previous study. 13 Within both groups of patients (stages I/II and stages III/IV), the IL-10 level further stratified patients into 2 categories with statistically significant, distinct overall survival (P ¼ .0066 and P ¼ .0002, respectively).…”

“…13 To examine the robustness of the prognostic significance of serum IL-10 and to minimize the problem of hypercollinearity, 2 multivariate analyses with different sets of data were conducted. For the first multivariate analysis, the following factors were included: sociodemographics (age, sex, ECOG performance status), log IL-10, tumor staging (BCLC, CLIP, TNM, Okuda, CUPI), treatment modality (locoablative therapy vs palliative therapy), Child-Pugh stage, ALT level, and MELD score.…”

“…[6][7][8][9] Several tumor staging systems have been established for predicting the prognosis of patients with different severities of HCC. [10][11][12][13] Interleukin 10 (IL-10) is a pleiotropic cytokine that plays a central role in modulation of the immune system in humans.…”

Staging of Hepatocellular Carcinoma

“…Various staging systems used in HCC include the European systems [French staging system, 6 Barcelona Clinic Liver Cancer (BCLC) staging system 7 and the cancer of the liver Italian program (CLIP) 8 ], Asian systems [Okuda staging system, 9 Japan integrated Staging (JIS), 10 Tokyo score 10 and Chinese University Prognostic Index (CUPI) 11 ].…”

“…CUPI performed the best in predicting 3-month survival while CLIP performed better in predicting the outcome of 6-and 12-month survival rate. 11 A study from Japan involving 1173 HCC patients found that the bm-JIS score showed good stratification ability and was demonstrated to be a better predictor of the prognosis than the c-JIS score and the BALAD score, especially for the patients with a good prognosis. 13 In a recent study 15 comparing CLIP staging with Okuda staging system and Child-Pugh scoring system, CLIP staging was found to give more accurate prognostic information in comparison to Okuda and Child-Pugh classification.…”