Prospects and Limitations of Systematic Monitoring in Patients with Laryngeal Cancer

Brunetti, Francesco; Menzio, P; Cortesina, G; Sartoris, A; Morra, B.; Bussi, Mario

doi:10.3109/00016487909126439

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…The E-rosette test and EAC-rosette test were performed at time of diag- The results of histologic examinations are summarized in Table I. As in our previous work,1 8 in some cases prevalent hyperplasia of both lymphatic sinuses macrophages (M.Hy) and thymus-dependent areas (T.D.A.Hy) were found. In other instances, hyperplasia of germinal centers (G.C.Hy) predominated.…”

Section: Methodsmentioning

confidence: 87%

Relationships between Cervical Node Histological Patterns and Rosette Test Scores: Possible Prognostic Value in Laryngeal Cancer

Menzio¹,

Cortesina²,

Sartoris³

et al. 1980

The Laryngoscope

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In previous research the authors have remarked that some hystological patterns — macrophagic hyperplasia and thymus‐dependent areas hyperplasia — when prevailing in cervical nodes of laryngeal cancer patients, possess a positive prognostic value. In this study the possible relationship between the results of E and EAC‐rosettes and prevailing hystologic patterns in cervical nodes is investigated. A positive correlation was not found. Conclusively, the inconsistency of aspecific tests for prognostic purposes and the need for a specific immunological monitoring system are outlined.

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Section: Methodsmentioning

confidence: 87%

Relationships between Cervical Node Histological Patterns and Rosette Test Scores: Possible Prognostic Value in Laryngeal Cancer

Menzio¹,

Cortesina²,

Sartoris³

et al. 1980

The Laryngoscope

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“…Pitanje odnosa imunol{okih poreme}aja u malignih oboljenja je od velikog teorijskog i prakti~nog zna~aja, njegovo re{enje moglo bi da doprinese razja{njenju patogeneze maligne bolesti i da omogu}i razvoj dijagnosti~kih metoda i imunoterapije. Medjutim ovo pitanje je zbog kontroverznih nalaza i nedostatka dobrog klini~kog modela jo{ uvek otvoreno 4,7,12 . Pre operacije, u obolelih od karcinoma larinksa registrovane su vrednosti IgG i IgA u nivou kontrolnih; smanjene koncentracije IgM; i pove}ane koncentracije CIC u serumu.…”

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“…Takodje, pacijenti sa karcinomom respiratornog traktã iji je deo i larinks, imaju povi{ene nivoe IgA i IgG u sekretu mukoze ove oblasti, a i u serumu 5,6 rezime nivoa serumskih imunoglobulina i da na njih ne uti~u terapijske procedure 3 . Nasuprot tome, u radovima drugih autora povi{eni nivoi serumskog IgA su imali prognosti~ki zna~aj i bili su u direktnoj korelaciji sa tumorskom kategorijom pacijenata sa laringealnim i nazofaringealnimkarcinomom 7 .…”

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“…Pored op{teg imunosupresi-vnog imunosupresivnog dejstva, interakcije malignog tkiva i imunolo{kog sistema imaju jo{ jedan va'an nivo, a {to je specifi~ni imunolo{ki odgovor na tumor asocirane antigene (TAA) 7,8,9 . U vezi s tim odgovorom se u odredjenoj fazi maligne bolesti pojavljuju i specifi~ni blokiraju}i serumski faktori, u po~etnoj fazi bolesti su to necitotoksi~na antitela, u srednjoj solubilni imuni kompleksi, a u kasnijim fazama bolesti imunokompleksi i solubilni antigeni.…”

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“…lo{om prognozom 9,10,11 . U bolesnika sa karcinomom larinksa takodje je nadjena po-ve}ana kon}entracija blokiraju}ih serumskih faktora 7,12,13 . Imuni kompleksi, mogu da nastanu i nezavisno od antigena malignih }elija i variraju pod uticajem fizio-lo{ih i patofiziolo{kih uticaja, stoga neki autori osporavaju veliku klini~ku vrednost odredjivanja imunih kompleksa u serumu obolelih od malignih bolesti.…”

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Immunoglobulins G, A, M and circulatory immune complexes in patients with laryngeal carcinoma

et al. 2009

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Immunobiologic Staging of Patients with Carcinoma of the Head and Neck

Katz

1983

The Laryngoscope

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For decades immunologic deficiencies have been documented in patients with carcinoma, and many investigators have attempted to utilize this information in determining prognosis more accurately. Determining prognosis more accurately would be most helpful with Stage III patients, since at present there are no useful guidelines as to which Stage III patients would benefit from aggressive surgery and/or radiation therapy and which would not. Assays of cellular immunity--such as skin testing, determining peripheral T-lymphocyte counts, and assessing lymphocyte reactivity--have achieved extremely limited clinical application. These assays are too expensive and/or too difficult to perform in the routine clinical setting. Total lymphocyte counts, however, are readily available in the clinical setting and can be helpful in determining prognosis. Other readily available clinical information, such as age and pretreatment serum immunoglobulin levels, can also be of value in determining prognosis. In this study, logistic regression was utilized to determine the prognostic implications of stage, age, and pretreatment total lymphocyte counts in 132 patients with carcinoma of the head and neck. Although each variable determined prognosis accurately less than 70% of the time, the stage, age, lymphocyte prognostic index (SALPI) accurately predicted outcome at 3 year follow-up 80% of the time (Pr. less than .0001). Discriminant function analysis was utilized to determine the prognostic implications of pretreatment serum immunoglobulins in 243 patients with head and neck carcinoma. A serum immunoglobulin prognostic index (SIPI) was derived which was based on the observations that elevated levels of immunoglobulin A (IgA) indicated a poor prognosis, while elevated levels of immunoglobulin E (IgE) and immunoglobulin D (IgD) indicated a favorable prognosis (Pr. less than .009). The SIPI was not as accurate as the SALPI in determining prognosis; however, when the indices were used simultaneously, concurring indices predicted the outcome of Stage III patients correctly 86% of the time.

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Prospects and Limitations of Systematic Monitoring in Patients with Laryngeal Cancer

Cited by 8 publications

References 21 publications

Relationships between Cervical Node Histological Patterns and Rosette Test Scores: Possible Prognostic Value in Laryngeal Cancer

Relationships between Cervical Node Histological Patterns and Rosette Test Scores: Possible Prognostic Value in Laryngeal Cancer

Immunoglobulins G, A, M and circulatory immune complexes in patients with laryngeal carcinoma

Immunobiologic Staging of Patients with Carcinoma of the Head and Neck

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