2023
DOI: 10.1159/000534185
|View full text |Cite
|
Sign up to set email alerts
|

Prospects and Pitfalls of Plasma Complement C4 in Schizophrenia: Building a Better Biomarker

Emily G. Severance,
Emese Prandovszky,
Shuojia Yang
et al.

Abstract: Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors interacting during neurodevelopment. Infections, inflammation, and autoimmune diseases are over-represented in schizophrenia leading to immune system-centered hypotheses. Complement component C4 is genetically and neurobiologically associated with schizophrenia, and its dual activity peripherally and in the brain makes it an exceptional target for biomarker development. Studies to… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(1 citation statement)
references
References 107 publications
(145 reference statements)
0
1
0
Order By: Relevance
“…Skalniak et al.’s study indicates that lower CRP and C4 complement levels predict greater symptom improvement after 12 weeks of antipsychotic treatment ( 89 ). In accordance, Dr Yolken’s team, with over two decades of research on infections and immune dysregulation in schizophrenia, recently published a pilot study discussing the potential value of CRP and C4 complement as informative biomarkers in schizophrenia ( 90 ).…”
Section: Research Studies In the Present Topicmentioning
confidence: 99%
“…Skalniak et al.’s study indicates that lower CRP and C4 complement levels predict greater symptom improvement after 12 weeks of antipsychotic treatment ( 89 ). In accordance, Dr Yolken’s team, with over two decades of research on infections and immune dysregulation in schizophrenia, recently published a pilot study discussing the potential value of CRP and C4 complement as informative biomarkers in schizophrenia ( 90 ).…”
Section: Research Studies In the Present Topicmentioning
confidence: 99%