Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches

Mohan, Sankari; Rao, Priya Rajendra; Hemachandran, Hridya; Pullela, Phani Kumar; C, George Priya Doss; Tayubi, Iftikhar Aslam; Babu, Subramanian; Gothandam, Kodiveri Muthukaliannan; Singh, Pooja; Siva, Ramamoorthy

doi:10.1016/j.jbiotec.2017.12.010

Cited by 42 publications

(22 citation statements)

References 200 publications

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“…Recent advances in molecular biology and metabolic engineering has helped in streamlining the process of pigment industrialization as described in Figure 3. For instance, tools involved in molecular biology helps in sequencing of fungal genomes and thus assist in identification of genes involved in production of pigmented metabolite (Sankari et al, 2018). The use of genome mining strategies for the discovery of new pigmented molecules is one of the most constructive techniques as it not only allows studying the complete metabolic capacity of fungal strain but also allows studying the gene clusters that are not expressed in standard laboratory culture conditions (Nielsen and Nielsen, 2017).…”

Section: Metabolic Engineeringmentioning

confidence: 99%

Fungi as a Potential Source of Pigments: Harnessing Filamentous Fungi

2020

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Section: Metabolic Engineeringmentioning

confidence: 99%

Fungi as a Potential Source of Pigments: Harnessing Filamentous Fungi

2020

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“…In fact, any synthetic biology approach will be limited by natural genetic variation, as described for carotenoids (Harjes et al, 2008;Lee et al, 2012;Schulz et al, 2016;Sulli et al, 2017;Price et al, 2018;Teixeira da Silva et al, 2018). Nonetheless, metabolic engineering of the pathway has been demonstrated for many crops (Giuliano, 2017;Majer et al, 2017;Nogueira et al, 2017Nogueira et al, , 2018Camagna et al, 2018;McQuinn et al, 2018;Sankari et al, 2018). These strategies have also included the successful application of gene editing technology (Dahan-Meir et al, 2018) which in the future could be used to incorporate favorable allelic variation from wild species.…”

Section: Carotenoids With Synthetic Biologymentioning

confidence: 99%

Changing Form and Function through Carotenoids and Synthetic Biology

Wurtzel

2018

Plant Physiol.

113

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Carotenoids are structurally diverse pigments and related derivatives that mediate photosynthetic function, responses to biotic and abiotic signals, and control plant architecture. It is these multifaceted roles that make carotenoids uniquely attractive as synthetic biology targets when considering ways to alter plant form and function to meet the needs of food security or new agricultural and industrial applications. This Update seeks to explore how synthetic biology might capitalize on the recent advances made in the carotenoid field. Opportunities are discussed along with the research needed to drive the carotenoid synthetic biology era forward.

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“…Blue pigment Actinorhodin, produced by Streptomyces coelicolor , has been genetically manipulated to produce a related bright yellow polyketide known as kalafungin, that is used to produce an antraquinone, which is a reddish-yellow color (148, 149). Heterologous expression has been used to develop cell factories to efficiently produce pigments by expressing biosynthetic pathways from novel or known pigment producers (150, 151).…”

Section: Technologies For Enhancing Pigment Productionmentioning

confidence: 99%

Microbial Pigments in the Food Industry—Challenges and the Way Forward

2019

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Developing new colors for the food industry is challenging, as colorants need to be compatible with a food flavors, safety, and nutritional value, and which ultimately have a minimal impact on the price of the product. In addition, food colorants should preferably be natural rather than synthetic compounds. Micro-organisms already produce industrially useful natural colorants such as carotenoids and anthocyanins. Microbial food colorants can be produced at scale at relatively low costs. This review highlights the significance of color in the food industry, why there is a need to shift to natural food colors compared to synthetic ones and how using microbial pigments as food colorants, instead of colors from other natural sources, is a preferable option. We also summarize the microbial derived food colorants currently used and discuss their classification based on their chemical structure. Finally, we discuss the challenges faced by the use and development of food grade microbial pigments and how to deal with these challenges, using advanced techniques including metabolic engineering and nanotechnology.

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Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches

Cited by 42 publications

References 200 publications

Fungi as a Potential Source of Pigments: Harnessing Filamentous Fungi

Fungi as a Potential Source of Pigments: Harnessing Filamentous Fungi

Changing Form and Function through Carotenoids and Synthetic Biology

Microbial Pigments in the Food Industry—Challenges and the Way Forward

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