Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity11Reprints are not available.

Griffin, Marie R.; Scheiman, James M.

doi:10.1016/s0002-9343(00)00634-3

Cited by 45 publications

(21 citation statements)

References 52 publications

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“…In spite of the rapidly changing concept of gastric ulcer management from conventional vagotomy, prostaglandin analogues, H 2 receptor antagonists, and antacids to proton pump inhibitors, gastrointestinal toxicity remains an impediment to their application in clinical practice. Specifically, gastrointestinal toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) origin may be as high as 4-8% per year and the complications are even higher for those with additional risk factors such as prior history of ulcer disease (Griffin & Scheiman, 2001). Various synthetic antiulcer drugs are presently available and some of these like cimetidine, misoprostol, ranitidine, omeprazole, and esomeprazole are employed to manage and cure NSAID-induced gastric ulcer.…”

Section: Introductionmentioning

confidence: 99%

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

Sabiu

Garuba

Sunmonu

et al. 2015

Pharmaceutical Biology

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Context: Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. Objective: The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Materials and methods: Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight (b.w.)). Ulcerated rats were orally administered with esomeprazole (a reference drug) at a dose of 20 mg/kg body weight, and Spondias mombin and Ficus exasperata at a dose of 100 and 200 mg/kg b.w. once daily for 21 d after ulcer induction. Gastric secretions and antioxidant parameters were thereafter evaluated. Results: The significantly increased (p50.05) ulcer index, gastric volume, malondialdehyde level, and pepsin activity by indomethacin were effectively reduced by 65.40, 36.47, 45.71, and 53.79%, respectively, following treatment with F. exasperata at 200 mg/kg b.w. S. mombin at this regimen also attenuated these parameters by 71.70, 46.62, 50.16, and 55.73%. Moreover, the extracts significantly increase the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. Discussion and conclusion: These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.

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Section: Introductionmentioning

confidence: 99%

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

Sabiu

Garuba

Sunmonu

et al. 2015

Pharmaceutical Biology

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“…The major risk factors associated with GI complications are age (risk increases with age), a history of peptic ulceration or GI bleeding, a history of H 2 RA use, concomitant use of anticoagulants or corticosteroids, requirement for high dosage of an NSAID and concurrent use of more than one NSAID. [4][5][6] Evidence reviewed for the recently published National Institute for Health and Clinical Excellence (NICE) guidelines 1 suggests that Cox-2 and Cox-1 NSAIDs are of equivalent efficacy in their ability to reduce pain and improve physical functioning in patients with arthritis. This evidence also suggests that, although GI adverse events occur more frequently among patients receiving Cox-2 medication than those receiving a placebo, the incidence of these events is markedly lower than among those receiving a conventional NSAID (Cox-1) without gastroprotection.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the cost-effectiveness of five strategies for the prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: a systematic review with economic modelling

Brown¹,

Hooper²,

Elliott³

et al. 2006

Health Technol Assess

137

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“…The most common GI adverse effects include GI perforations, ulcerations, and bleeding, all of which may require hospitalization 6 . The NSAID mediated toxicity is often dose related 7 . Thus reduction in serum concentration should also lessen the risk of potentially serious systemic adverse effects secondary to NSAID induced prostaglandin inhibition such as acute renal insufficiency, nephritic syndrome, NSAID gastropathy, prolonged bleeding time, and fluid retention.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Alam¹,

Baboota²,

Kohli³

et al. 2010

ScienceAsia

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A low dose proniosomal gel containing celecoxib was developed for the treatment of osteoarthritis. All the prepared formulations were subjected to physicochemical evaluations and anti-inflammatory studies. The entrapment was > 90%. The vesicle shape was determined with the help of transmission electron microscopy. The vesicle size, sizedistribution, and polydispersity studies were performed using photon correlation spectroscopy. Anti-inflammatory studies were performed using the rat hind-paw oedema induced by carrageenan (1% w/v). The selected proniosomal gel (N1LE3) produced 100% inhibition of paw oedema in rats up to 8 h after carrageenan injection. It produced 95% and 92% inhibition after 12 h and 24 h, respectively. These results indicate that proniosomes are a promising carrier for the transdermal delivery of celecoxib. Thus celecoxib can be formulated into a low dose proniosomal gel that can save the recipient from the adverse effects of large doses.

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Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity11Reprints are not available.

Cited by 45 publications

References 52 publications

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

A comparison of the cost-effectiveness of five strategies for the prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: a systematic review with economic modelling

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