Prospects for Multimodality Imaging in Peripheral Artery Disease

Kinlay, Scott

doi:10.1161/circimaging.113.001434

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The underlying mechanism for the observed association has not been clearly elucidated. Previous studies suggested that both impaired vasculature and skeletal muscle pathophysiologic changes contributed to the lower extremity dysfunction in PAD participants [17][18][19][20]. People with PAD have smaller calf muscle area and increased calf muscle percent fat than people without PAD [21,22].…”

Section: Discussionmentioning

confidence: 99%

Association between calf girth and peripheral artery disease in the Atherosclerosis Risk in Communities Study

Liang

Zhang

Sun

et al. 2020

Journal of Cardiology

View full text Add to dashboard Cite

Background: The pathogenesis of peripheral artery disease (PAD) is associated with impaired calf muscle. We sought to investigate the association between gender-specific calf girth and the prevalence of PAD among participants from a community-based cohort study. Methods: A total 13,808 participants in the Atherosclerosis Risk in Communities (ARIC) study without prior PAD were included in the final analysis. Calf girth was measured at baseline (1985)(1986)(1987). A hospital diagnosis with an ICD-9 code defined incident PAD during follow up. Cox regression analysis adjusted for demographic variables and other covariates was used to estimate hazard ratios (HR) and 95% confidence interval (CI) for the association between calf girth and PAD. Results: After a medium follow-up of 25.2 years, the overall prevalence of PAD in our study was 5.2% (721/ 13,808), 335 patients were women and 386 were men. The adjusted HR for PAD with calf girth as continuous variables was 0.99 (95% CI 0.95-1.04) in females and 0.93 (95% CI 0.88-0.99) in males, respectively. Moreover, interaction for gender was statistically significant between calf girth and PAD in overall population (p = 0.001). Conclusions: Our findings revealed a linear association of calf girth with the prevalence of PAD among male participants in ARIC.

show abstract