Prospects for phytopreparations (botanicals) use in modern pharmacology

Владимировна²,

Rev Clin Pharm Drug Ther

et al. 2020

The article presents a review of the literature on the use of a variety of herbal remedies, showing pronounced immunotropic and adaptogenic properties, as correctors of violations of the immune status, developing in various pathological conditions. The information about the advantages of the use of drugs of plant origin in comparison with synthetic drugs, such as "soft" immunomodulatory effect, low toxicity, beneficial effect on metabolic processes, a wide range of biological effects due to the ability of herbal remedies to activate the functions of not only immune but also neuroendocrine systems. In addition, the article discusses some of the mechanisms of immunometabolic, antioxidant and adaptogenic effects of some herbal remedies, which serve as the basis for further study of their biological properties in order to expand the possibilities of phytopreparations in the arsenal of modern pharmacology.

Section: заключениеunclassified

Some mechanisms of immunotropic and adaptogenous effect of phytopreparations

Владимировна²,

Rev Clin Pharm Drug Ther

et al. 2020

Proceedings of the International Scientific Conference the Fifth Technological Order: Prospects for the Development and Moderni

“…The main advantage of herbal remedies (or phytodrugs) over synthetic drugs is a mild moderate effect on the body with the gradual development of a therapeutic effect. In addition, the phytodrugs in animal husbandry does not impose restrictions on their use [1]. In practical veterinary medicine, the expert use of phytopreparations can prevent and treat many animal diseases, reduce livestock mortality, and reduce the cost of expensive chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

The “Urticostim” Phytocomposition’s Impact on the Hematological and Immunological Status of Experimental Animals

Veretennikova¹,

Boyko²,

Vlasenko³

et al. 2020

An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition -Urticostim‖ effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8% and 3%, respectively. A dose of 0.1 ml/kg caused a decrease in the bilirubin concentration of rats by 30% compared with the control indices. Daily administration of a 2.0 ml/kg dose for 14 days led to an increase in urea concentration by 20%. A dose of 0.1 ml/kg increased the absolute number of lymphocytes due to all populations of lymphoid cells. Quantitative fluctuations of T and B lymphocytes and cytotoxic T lymphocytes were characterized by an increase of 1.58, 1.66 and 1.47 times, respectively, relative to the control group indices. With an increase in the Urticostim dose by 10-20 times, a significant decrease in the concentration of T lymphocytes to 0.5±0.2 thousand/μl was noted versus 1.2±0.1 thousand/μl in the control index, as well as cytotoxic T lymphocytesup to 1.2±0.2 thousand/μl versus 1.9±0.2 thousand/μl. The number of B lymphocytes was at the same level as the control values.

EUREKA: Health Sciences

“…The issue of therapy of gastroenterological diseases is given the attention of many specialists of medicine and pharmacy. Phytotherapy in the treatment of this group of diseases occupies a special place [2,3]. Scientists have reported the use of raw materials of such medicinal plants as aloe tree, blueberries, wormwood in ulcerative colitis; caraway seeds, medicinal chamomile, peppermint, medicinal lemon balm -with gastrointestinal cramps, gastritis, ulcers; calamus -in chronic dyspepsia, flatulence; angelica -for irritable bowel syndrome [4].…”

Section: Introductionmentioning

confidence: 99%

Research on the Selection of Excipients as the Rationale for the Composition of the Tablets With Dry Extract of Sanguisorba Officinalis

Shulga

Bezkrovna

Domar

2020

The aim. The aim of the research was to study the effect of different groups of excipients on the pharmaco-technological propertiesof the powder mass for tabletting in the development of the composition of the tablets with dry extract of Sanguisorba officinalis for complex therapy of the gastrointestinal tract diseases.Materials and methods. Objects of study -dry extract Sanguisorba officinalis, 25 excipients used in the production of tablets by the method of direct compression, grouped into five groups of factors (fillers based on sugars and microcrystalline cellulose, disintegrants, glidants and lubricants), samples of powder masses. Studies on the determination of pharmaco-technological properties (fluidity, bulk density, bulk density after shrinkage, degree of compressibility, Hausner ratio, and angle of repose) of the obtained powder masses were carried out according to the methods of the State Pharmacopoeia of Ukraine, Second edition. The method of mathematical planning of the experiment was used in the work, the obtained results were subjected to variance analysis, and the ranked series of advantages were placed, in which the excipients were placed in the sequence of their influence on the studied pharmaco-tecnological parameters.Results and discussion. The influence of excipients (factors) on the pharmaco-technological properties (responses) of the powdered tablet masses with the construction of ranked benefits was studied using a five-factor experiment, a hyper-Graeco-Latin square. The results of the analysis of variance showed that glidants have the greatest influence on the fluidity, the bulk density and the bulk density after shrinkage. Neusilin US 2 significantly affects the fluidity of the powder masses and Hausner ratio, the Talc having the greatest effect on the bulk density and the bulk density after shrinkage of the powder masses. The representative of the disintegrants group -Sodium starch glycolate most influences the compressibility index, the sugar-based filler -Pearlitol 500 DC -on the angle of repose.Conclusions. The effect of 25 excipients on the pharmaco-technological characteristics of the powdered tablet masses with dry extract of Sanguisorba officinalis was studied. It was found that among the sugars-based fillers equally good results were shown © The Author(s) 2020 This is an open access article under the CC BY license Original Research Article: full paper (2020), «EUREKA: Health Sciences» Number 2 67Pharmacology, Toxicology and Pharmaceutical Science in the powder masses with Compri sugar, Tablettose 80 and Pearlitol 500 DC; among the microcrystalline cellulose based fillers is Prosolv 90; among glidants -Neusilin US 2; no comparison was made of the disintegrants and lubricant excipients from the studied list of leader substances. The results of the studies indicate the possibility of obtaining tablets by the direct compression method, and further study of their pharmaco-technological characteristics will allow to establish the optimal composition of excipients.