2023
DOI: 10.17816/kmj346694
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Prospects for the creation of new drug candidates with antidepressant activity among thietanes

Irina L. Nikitina,
Gulnara G. Gaisina,
Elena E. Klen
et al.

Abstract: The article presents the results of systematic studies on the search for new biologically active molecules with antidepressant activity in the series of thietane-containing heterocyclic compounds and 3-substituted thietane dioxides. The used strategy for the search for antidepressant substances, based on in vivo pharmacological screening in combination with in silico methods of mathematical modeling and toxico-pharmacokinetic evaluation, is described. Studies of the biological activity of thietane-containing r… Show more

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