Prospects for the treatment of preeclampsia

Сидорова, И. С.; Nikitina, Nikitina N.A.

doi:10.18565/aig.2018.6.5-10

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 Preeclampsia as the main obstetric pathology is inherently considered at present as an immunological phenomenon. 18 The development of preeclampsia is a reaction similar to rejection of an allograft and the production of various antibodies, including antiphospholipid ones. 19 It is believed that immune processes not only contribute to the development of preeclampsia, but also determine its severity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of cytokines in pregnant women with chronic iron deficiency anemia in preeclampsia pathogenesis

K¹,

T²,

Da³

2020

OGIJ

View full text Add to dashboard Cite

The frequency of development of hypertensive states in IDA reaches 32-45%. The pathogenesis of the combined complications of pregnancy with anemia and preeclampsia, including immunological aspects has been little studied. Purpose: to clarify the role of violations general and local cytokine status in pregnant women with anemia in the genesis of preeclampsia and justify the need to include immuno suppressants for the prevention and treatment of preeclampsia. Materials and methods: In 96 pregnant women with iron deficiency anemia (IDA) and preeclampsia in the third trimester of gestation the cytokine status of IL-1β, IL-6, IL-8, TNFα and lactoferrin in the serum of peripheral blood and in extracts of the placenta decidual tissue was examined by ELISA. Pregnant women were divided into 4 groups: 24-with mild anemia, 18-with moderate anemia, 26-with preeclampsia and with mild anemia and 28 pregnant women with preeclampsia and with moderate anemia. Results: It has been established that preeclampsia on the background of IDA is accompanied by a significant increase in the level of pro-inflammatory cytokines (p<0,05) and the acute phase protein lactoferrin (p<0,05) on the systemic and to a greater extent on the local level in the development of preeclampsia on the background of anemia of moderate severity (p<0,05). Discussion: The data obtained confirm the involvement of the immune system in the pathogenesis of preeclampsia, one of the trigger mechanisms of which is the immune imbalance in iron deficiency anemia. A pathogenetic rationale for the use of immunosuppressive therapy for combined pathology is given. Conclusion: The use of placental hormone - progesterone as an immunosuppressive drug in terms of substantiating new immunotherapy strategies for the prevention of preeclampsia is a topical trend in obstetric practice.

show abstract

Section: Introductionmentioning

confidence: 99%

“…19 It is believed that immune processes not only contribute to the development of preeclampsia, but also determine its severity. 17,18,20 The aim of the study was to clarify the role of violations of the general and local cytokine status in pregnant women with anemia in the genesis of preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Role of cytokines in pregnant women with chronic iron deficiency anemia in preeclampsia pathogenesis

K¹,

T²,

Da³

2020

OGIJ

View full text Add to dashboard Cite

show abstract

Efficacy of using progesterone as an immunosuppressant for the prevention of preeclampsia in pregnant women with iron-deficiency anemia

Djabbarova,

Ismoilova,

Ziyaeva

et al. 2023

Journal of obstetrics and women's diseases

View full text Add to dashboard Cite

BACKGROUND:In previous studies, our data on the activation of pro-inflammatory cytokines at the systemic and local levels indicated an inadequate maternal immune response to fetal egg antigens against the backdrop of endocrine system restructuring and iron-deficiency anemia, which is a fundamental mechanism underlying the pathogenesis of preeclampsia. The above was the basis for the use of immunotherapy at a high risk of developing preeclampsia in pregnant women. AIM:The aim of this study was to evaluate the use of micronized progesterone as an immunosuppressant for the prevention of preeclampsia in pregnant women with iron-deficiency anemia. MATERIALS AND METHODS:We examined 44 pregnant women with iron-deficiency anemia in dynamics by trimesters of pregnancy: patients before and after taking micronized progesterone (main group,n= 25) and untreated pregnant women (comparison group,n= 19). We used general clinical and laboratory methods, assessing serum progesterone levels at 46, 2528 and 3236 weeks of pregnancy before and after the treatment, as well as statistical methods using evidence-based medicine approaches. RESULTS:Taking micronized progesterone in pregnant women with iron-deficiency anemia from early gestation increased blood progesterone level by 1.5 times by 28 weeks of pregnancy (p 0.05) and by 2.5 times by 3234 weeks of pregnancy (p 0.05) compared to that in women who did not take the hormonal drug. In case of progesterone deficiency in pregnant women with iron-deficiency anemia and mild preeclampsia, the administration of micronized progesterone elevated its blood level by 2.4 times (p 0.05), but in severe preeclampsia in untreated women, the hormone concentrations were reduced. In women with iron-deficiency anemia, due to the inclusion of progestogen in standard antianemic therapy from early stages and throughout pregnancy, the incidence of severe preeclampsia and preterm birth was decreased in 93.3% of cases, which led to a live birth in most cases. CONCLUSIONS:Micronized progesterone in pregnant women may be used to correct progesterone deficiency conditions, one of which is iron-deficiency anemia, and, as an immunosuppressant, to protect the fetus from an aggressive maternal immune response, manifested by the development of preeclampsia and other complications. The use of the gestagen therapy from early pregnancy is a promising tool for the prevention of preeclampsia in pregnant women with iron-deficiency anemia. Undoubtedly, further and more extensive research is needed to better understand this issue.

show abstract

Prospects for the treatment of preeclampsia

Cited by 2 publications

References 0 publications

Role of cytokines in pregnant women with chronic iron deficiency anemia in preeclampsia pathogenesis

Role of cytokines in pregnant women with chronic iron deficiency anemia in preeclampsia pathogenesis

Efficacy of using progesterone as an immunosuppressant for the prevention of preeclampsia in pregnant women with iron-deficiency anemia

Contact Info

Product

Resources

About