Prospects for the Use of Genome-Editing Technology to Correct Neurodegenerative Diseases

Using Genome Editing for Alzheimer’s Disease Therapy: from Experiment to Clinic

“…OF ALZHEIMER'S DISEASE The achievements of functional genomics have significantly advanced the understanding of the brain at the cellular level in normal and pathological conditions, providing a number of tools that allow us to study the role of individual genes in models on cells and living organisms. Thus, genetic factors associated with the development of a whole number of neurological diseases, including AD, Parkinson's disease, Huntington's disease, and others were introduced in the genome of animals and investigated (see, for example [50][51][52]). CRISPR-Cas9 probably significantly simplifies and facilitates the modification of genes compared to the other tools and can be used for the development of approaches to the therapy of inherited and sporadic AD (Fig.…”