2022
DOI: 10.17749/2070-4909/farmakoekonomika.2022.145
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Prospects for the use of chondroitin sulfate and glucosamine sulfate in the treatment of patients with obesity-associated osteoarthritis (metabolic syndrome)

Abstract: The relationship between the pathophysiology of osteoarthritis (OA) and metabolic disorders (metabolic syndrome, obesity) is provided not only by mechanical causes (increased body weight pressure on the joints). A complex of molecular mechanisms, which mediates OA effect on the development of obesity, was established. Excessive activity of toll receptors, the NF-κB cascade, and metabolic disorders of endogenous chondroitin sulfates (CS) lead to chronic inflammation and the development of a complex of comorbid … Show more

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Cited by 2 publications
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“…Pain reducing, disease progress delay, deformities correcting, and joint function enhancing are the main directions of KO treatment[ 19 , 20 ]. The current KO treatment is divided into phased and individualized treatment methods.…”
Section: Discussionmentioning
confidence: 99%
“…Pain reducing, disease progress delay, deformities correcting, and joint function enhancing are the main directions of KO treatment[ 19 , 20 ]. The current KO treatment is divided into phased and individualized treatment methods.…”
Section: Discussionmentioning
confidence: 99%