Prospects for using silicon nanoparticles fabricated by laser ablation in hyperthermia of tumours

Sokolovskaya, O.I.; Zabotnov, S. V.; Golovan, L. A.; Кашкаров, П. К.; Kurakina, Daria; Сергеева, Е. А.; Kirillin, Mikhail

doi:10.1070/qel17487

Cited by 7 publications

(5 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our preliminary studies, we demonstrated that a stationary temperature distribution is achieved in less than 400 s of cw irradiation [39]. It is worth noting that, according to the requirements of the hyperthermia procedure, the irradiation time in cw regime may take up to 60 min [92].…”

Section: Calculation Of Volumetric Temperature Distributionmentioning

confidence: 65%

“…At the same time, in this wavelength range, the absorption of light by silicon decreases with the increase in wavelength [56]. Our previous study [39] compared the application of the wavelengths of 633 and 800 nm for nanoparticle-mediated tumor hyperthermia. It was shown that at equal intensities the wavelength of 633 nm provides higher local heating, which determined the choice of this wavelength for this study.…”

Section: Geometry and Optical Parameters Of The Modelmentioning

confidence: 98%

“…Figure 6 shows axial and transversal profiles of the temperature distribution for r = 2.5 mm and power 110 mW (corresponding intensity I = 560 mW/cm 2 [50]) in biotissue with and without SiNPs. This combination of r and I parameters ensures heating of the entire tumor volume to temperatures above T 42 in the presence of eSiNPs at concentrations higher than 5 mg/mL, although it is worth mentioning that, besides quite a high value of intensity itself, it requires longer than 400 s to reach the stationary heating mode considered in simulations [5,39]. For the tumor without SiNPs, the employed beam intensity allows reaching T 42 at the beam axis through the whole tumor length (Figure 6a).…”

Section: Beam Size Equals the Tumor Transversal Sizementioning

confidence: 99%

“…SiNPs were additionally found to be promising as thermal coupling agents for hyperthermia [37][38][39]. In vitro experiments on a cell culture exposed to near-infrared laser irradiation demonstrated a significant reduction of tumor cell viability in the presence of SiNPs [37].…”

Section: Introductionmentioning

confidence: 99%

“…Experiments in vivo demonstrated that porous silicon in combination with laser irradiation allows for the selective destruction of cancer cells without damaging surrounding healthy cells [38]. Numerical simulations of laser tumor hyperthermia [39] demonstrated the increase of maximum tumor temperature by 4 • C due to SiNPs presence in the tumor site.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power.

show abstract

Section: Calculation Of Volumetric Temperature Distributionmentioning

confidence: 65%

Section: Geometry and Optical Parameters Of The Modelmentioning

confidence: 98%

Section: Beam Size Equals the Tumor Transversal Sizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

View full text Add to dashboard Cite

show abstract

Laser fragmentation of silicon microparticles in liquids for solution of biophotonics problems

Nesterov¹,

Sokolovskaya²,

Golovan³

et al. 2022

Quantum Electron.

View full text Add to dashboard Cite

The possibility of manufacturing silicon nanoparticles by picosecond laser fragmentation of silicon microparticles in water is analysed. It is shown that for fragmentation duration of 40 min, the dependence of the average sizes of particles on the initial mass concentration of the micropowder varied in the range of 0.5–12 mg mL-1 is nonmonotonic, with the maximum average size of 165 nm being achieved at a concentration of 5 mg mL-1. To explain the obtained result, the simulation of propagation of a focused laser beam in a scattering suspension of silicon microparticles is performed for their different mass concentrations. It is demonstrated that at concentrations not exceeding 5 mg mL-1, fragmentation occurs in the paraxial region of the beam when it propagates deep into the cuvette with a suspension, while at higher concentrations it occurs primarily in the superficial layer owing to strong extinction. Calculations results allow the experimental features of the formation of silicon nanoparticles to be explained. Spectrophotometry measurements on suspensions of nanoparticles obtained at the initial concentration of microparticles of 12 mg mL-1 are compared with the theoretical estimates of the absorption and scattering coefficients obtained in the framework of the Mie theory. Measured optical properties indicate the potential of using fragmented nanoparticles as scattering and/or absorbing contrast agents in optical imaging of biological objects.

show abstract

Enhancement of skin tumor laser hyperthermia with Ytterbium nanoparticles: numerical simulation

Othman,

Hassan,

Karim

2024

Biomed. Mater.

View full text Add to dashboard Cite

Laser hyperthermia therapy (HT) has emerged as a well-established method for treating cancer, yet it poses unique challenges in comprehending heat transfer dynamics within both healthy and cancerous tissues due to their intricate nature. This study investigates laser HT therapy as a promising avenue for addressing skin cancer. Employing two distinct near-infrared (NIR) laser beams at 980 nm, we analyze temperature variations within tumors, employing Pennes’ bioheat transfer equation as our fundamental investigative framework. Furthermore, our study delves into the influence of Ytterbium nanoparticles (YbNPs) on predicting temperature distributions in healthy and cancerous skin tissues. Our findings reveal that the application of YbNPs using a Gaussian beam shape results in a notable maximum temperature increase of 5 °C within the tumor compared to nanoparticle-free heating. Similarly, utilizing a flat top beam alongside YbNPs induces a temperature rise of 3 °C. While this research provides valuable insights into utilizing YbNPs with a Gaussian laser beam configuration for skin cancer treatment, a more thorough understanding could be attained through additional details on experimental parameters such as setup, exposure duration, and specific implications for skin cancer therapy.

show abstract

Prospects for using silicon nanoparticles fabricated by laser ablation in hyperthermia of tumours

Cited by 7 publications

References 55 publications

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Laser fragmentation of silicon microparticles in liquids for solution of biophotonics problems

Enhancement of skin tumor laser hyperthermia with Ytterbium nanoparticles: numerical simulation

Contact Info

Product

Resources

About