Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance

Payganova, N E; Yastremsky, A. P.

doi:10.17116/otorino202186031104

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…Antimicrobial Peptides (AMPs) are a class of small molecular peptides produced by the body to resist the invasion of pathogenic microorganisms when pathogenic microorganisms invade which have good inhibitory effect and are the first line of defense of the body's innate immune system and are resistant to most drug-resistant bacteria, viruses, fungi, etc (Payganova et al, 2021;Gumienna et al, 2021;Sahoo et al, 2021). Antimicrobial peptides have a wide range of sources, exist in most organisms, and can be isolated from insects, invertebrates, mammals, and even humans.…”

Section: Introductionmentioning

confidence: 99%

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Zhao

2021

SMLNUVMB

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The porcine intestinal epithelial cell line IPEC-J2 cells, which were isolated from neonatal piglet mid-jejunum, the main components of the intestinal epithelium and play an important role in the intestine. Escherichia coli is an important cause of diarrhea in human and animal. E.coli infections are the leading cause of travelers' diarrhea and a major cause of diarrhea in developing nations, where it can be life-threatening among children. The aim of this study is to explore MPX against E. coli to inhibit IPEC-J2 cells apoptosis and enhance cell barrier. In this study, scanning electron microscopy results found that E. coli infection caused cell apoptosis and destroyed cell membranes of IPEC-J2 cell. MPX effectively alleviated apoptosis of IPEC-J2 cells. The laser confocal results further found that MPX prevented cell apoptosis by inhibiting caspase-3 and caspase-9 activation. In addition, it was found that MPX regulated the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in IPEC-J2 cells and is closely related to Rac1 by adding a Rac1 inhibitor. The results of adhesion and invasion experiments further found that MPX inhibited bacterial adhesion and invasion through Rac1. The above results indicated that MPX has better function in inhibiting IPEC-J2 cells apoptosis and enhancing cell barrier.

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Section: Introductionmentioning

confidence: 99%

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Zhao

2021

SMLNUVMB

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Microbial colonization of the nasal mucosa in the elderly with chronic rhinosinusitis

Tarasova,

Belan,

Stepanenko

et al. 2024

Saratov J Med Sci Res

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Objective: to study the bacteriological landscape of nasal secretions from the middle nasal passage in patients with chronic rhinosinusitis (CRS) aged 60 to 95 years and to identify the most significant genera and types of microorganisms characteristic of the treatment of chronic rhinosinusitis in this age group. Material and methods. Taking into account the inclusion and non-inclusion criteria, 83 patients were selected, of which the following groups were formed by age and presence of CRS: group 1 (comparison group 1) — patients without CRS aged 60-74 years (n=24); group 2 — (comparison group 2) patients without CRS aged 75-95 years (n=20); group 3 — patients with CRS aged 60-74 years (n=22) and group 4 — patients with CRS aged 75-95 years (n=18). All patients received swabs from the middle nasal passage. The obtained samples were sent for bacteriological examination to identify microorganisms. Results. The level of representatives of the genera Staphylococcus spp. with CRS in the elderly and senile 66.6 and 16.6%, respectively, Enterococcus spp. were seeded 66.6 and 16.6%. The presence of Klebsiella pneumoniae (16.6%), Klebsiella oxytoca (5.8%) and Pseudomonas aeruginosa (11.1%) indicates the risk of long-term persistent upper respiratory tract infections. In the group of patients with CRS aged 60-74, representatives of the genus Candidiales (5.5%) were seeded. Conclusion. S. aureus, S. haemolyticus and Enterococcus faecalis were the overwhelming species in elderly patients (60-74 years old). Microflora diversity in patients aged 75-95 years Klebsiella pneumoniae (16.6%), Klebsiella oxytoca (5.8%) and Pseudomonas aeruginosa (11.1 %) it affects the course and possible complications of CRS.

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Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx

Гуров¹,

Dubovaya²,

Ermolaev³

et al. 2022

Vestn. otorinolaringol.

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Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance

Cited by 6 publications

References 14 publications

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Microbial colonization of the nasal mucosa in the elderly with chronic rhinosinusitis

Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx

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