Prospects of Curcumin Use in Nanobiotechnology

Kaniuk, M. I.

doi:10.15407/biotech9.03.023

Cited by 6 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is able to reduce the toxicity of DOX on the heart and liver [13,67], kidneys, brain, and reproductive organs, affecting the balance between the autophagy and apoptosis systems, reducing damage to energy production in the mitochondria of these organs [69]. The use of NPs significantly increases the bioavailability of CUR and its therapeutic effects [77,78], which reduce DOXmediated cardiotoxicity [10].…”

Section: Curcumin and Doxorubicinmentioning

confidence: 99%

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

Kaniuk¹

2023

Biotechnol. acta

Self Cite

View full text Add to dashboard Cite

The aim of the work was to review literature data on combined nanochemotherapy using the example of two drugs ̶doxorubicin and curcumin. Special attention was paid to the use of substances with synergistic properties in one nanoparticle, capable to penetrate into living cell. The method of combined chemotherapy of nanopreparations improves processing efficiency. The technique of using nanocontainers with synergistic drugs in combination with ligands reduces the side effects of chemotherapy drugs. Results. Literature data indicate that the use of nanopreparations contributes the rapid creation and use of synergistic combinations that were purposefully delivered to target cells, reducing dosage due to precise targeting. A promising direction of nanomedicine is the creation of multifunctional nanomaterials based on several active drugs having synergistic properties, with the simultaneous use of their enhancers and the strategy of active targeting. These structures enabled targeted and controlled penetration of medicinal compounds into the localization of pathological processes, reducing drugs toxicity for normal cells. Conclusions. Combined chemotherapy using polymers and nanoparticles with ligands, in which synergistic drugs are included, ensures to reduce side effects and doses of chemotherapy drugs, and helps to overcome multiple drug resistance as well.

show abstract

Section: Curcumin and Doxorubicinmentioning

confidence: 99%

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

Kaniuk¹

2023

Biotechnol. acta

Self Cite

View full text Add to dashboard Cite

show abstract

“…Curcumin (CUR) is a low-toxic natural drug derived from polyphenols extracted from Zingiberaceae plants. CUR has great prospects in the prevention and treatment of various diseases [60,61]. Significant prophylactic and/or therapeutic effects of CUR were observed in experimental animal models of a number of diseases, including atherosclerosis, diabetes, diseases of the eyes, respiratory organs, liver, pancreas, intestines, stomach, and neurodegenerative diseases [4].…”

Section: Curcuminmentioning

confidence: 99%

“…The use of nanoparticle compositions to increase the bioavailability of curcumin is a new direction of research [63]. To that end, a large number of nanomaterials have been developed to enhance the effect of CUR in vitro and in vivo [15,40,60,61].…”

Section: Curcuminmentioning

confidence: 99%

Multifunctional Nanosystems Based on Two Fluorescent Dyes, Doxorubicin and Curcumin

Kaniuk¹

2022

Biotechnol. acta

Self Cite

View full text Add to dashboard Cite

The aim of the work was to review the literature data regarding the prospects for the creation and use of multifunctional fluorescent two-dye nanosystems, which enable investigating the distribution of fluorescent components with significant acceleration of the study and introduction of nanomedicines into practice. Special attention is paid to the use of two substances with hydrophobic and hydrophilic properties in one nanoparticle (NP), capable of penetrating a living cell. The method of fluorescence confocal microscopy enables observation of the nanoscale dynamics of distribution and stability of drugs over time. The concomitant use of doxorubicin (DOX) and curcumin (CUR) in single nanoparticle causes synergism in the action of medical drugs, and their own fluorescence makes it possible to use them as multifunctional fluorescent nanosystems. Results. Data from the literature indicate that the use of two or more fluorescent dyes provide an advantage over other, more expensive methods when studying the penetration and distribution of NPs in living samples. The use of nanocarriers is an effective way to significantly increase the bioavailability of those drugs, which are poorly soluble in water. A promising direction of nanomedicine is the creation of complex bio-compatible multifunctional nanomaterials based on several active drugs, with the simultaneous use of their enhancers and the strategy of active targeting. Such recent structures enable targeted and controlled penetration of medicinal compounds into the sites of localization of pathological processes, reducing the toxicity of drugs to normal cells. Conclusions. The use of the fluorescence microscopy method, as exemplified by the two dyes, DOX and CUR, enables to trace the stages of interaction of loaded DOX and CUR nanoparticles with cultured cells, and their release from NPs to determine their amount and localization in organelles cells.

show abstract