Prospects of exogenous inositols in maintaining of skin, hair and nails condition: A review

Abstract

Myoinositol (MI) and D-chiroinositol (DCI), used in the therapy of menstrual disorders, polycystic ovarian syndrome (PCOS), hirsutism, acne, gestational diabetes, and other diseases, are required for intracellular signal transduction from insulin and other hormone receptors. Clinical practice shows that, for instance, MI and DCI in the treatment of PCOS improve the condition of skin, hair, and nails. These effects of MI and DCI are related to the normalization of insulin signaling and support of differentiation and growth of various skin cell types (keratinocytes, fibroblasts, epitheliocytes, etc.). The effects of MI and DCI on the skin and its appendages, including in wound healing, can be enhanced by manganese, which provides an antioxidant effect and improves the connective tissue matrix of the skin, and folic acid, which is involved in amino acid metabolism, proliferation, and differentiation of dividing cells.

The role of hsa‐miR‐193a‐5p as an important factor for control of inositol in alopecia areata

“…Moreover, a constellation of intracellular signaling pathways, including but not limited to Phosphatidylinositol 3‐kinase, protein kinase C, and calcium, assumes a pivotal role in bolstering cell proliferation within mammalian balance epithelia, thereby potentially contributing to the process of hair cell regeneration. 44 , 45 …”

“…Moreover, a constellation of intracellular signaling pathways, including but not limited to Phosphatidylinositol 3-kinase, protein kinase C, and calcium, assumes a pivotal role in bolstering cell proliferation within mammalian balance epithelia, thereby potentially contributing to the process of hair cell regeneration. 44,45 The cells known as dermal papilla cells, which are in the hair follicle, play a crucial role in producing signals that are responsible for controlling the actions of the adjacent epithelial cells throughout the hair cycle. These significant findings propose that the inositol phosphatecalcium signaling system and activated signaling pathways potentially participate in the intricate mechanisms that underlie the functions of hair, such as its growth, regeneration, and maintenance.…”

“…It is worth noting that inositol phosphates, exemplified by inositol 1,4,5 trisphosphate, emerge as key players in the regulation of cytosolic calcium concentrations, a crucial aspect of hair cell function. Moreover, a constellation of intracellular signaling pathways, including but not limited to Phosphatidylinositol 3‐kinase, protein kinase C, and calcium, assumes a pivotal role in bolstering cell proliferation within mammalian balance epithelia, thereby potentially contributing to the process of hair cell regeneration 44,45 …”