Gamma-ray and fast-neutron imaging was performed with a novel liquid xenon (LXe) scintillation detector read out by a Gaseous Photomultiplier (GPM). The 100 mm diameter detector prototype comprised a capillary-filled LXe converter/scintillator, coupled to a triple-THGEM imaging-GPM, with its first electrode coated by a CsI UV-photocathode, operated in Ne/5%CH4 at cryogenic temperatures.Radiation localization in 2D was derived from scintillation-induced photoelectron avalanches, measured on the GPM's segmented anode. The localization properties of 60 Co gamma-rays and a mixed fastneutron/gamma-ray field from an AmBe neutron source were derived from irradiation of a Pb edge absorber. Spatial resolutions of 12±2 mm and 10±2 mm (FWHM) were reached with 60 Co and AmBe sources, respectively. The experimental results are in good agreement with GEANT4 simulations. The calculated ultimate expected resolutions for our application-relevant 4.4 and 15.1 MeV gamma-rays and 1-15 MeV neutrons are 2-4 mm and ~2 mm (FWHM), respectively. These results indicate the potential applicability of the new detector concept to Fast-Neutron Resonance Radiography (FNRR) and Dual-Discrete-Energy Gamma Radiography (DDEGR) of large objects. and simulations (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc); Micropattern gaseous detectors (MSGC, GEM, THGEM, RETHGEM, MHSP, MICROPIC, MICROMEGAS, InGrid, etc); Photon detectors for UV, visible and IR photons (gas) (gas-photocathodes, solid-photocathodes); Neutron detectors (cold, thermal, fast neutrons); Gamma detectors (scintillators, CZT, HPG, HgI etc); Detection of contraband and drugs; Detection of explosives 2 1 IntroductionGamma-ray and fast-neutron imaging technologies are currently applied for investigating the content of aviation-and marine-cargo containers, trucks and nuclear waste containers (see for example [1, 2]). MeV-scale x-ray or gamma-ray radiographic inspection methods, such as Dual Energy Bremsstrahlung Radiography (DEBR) [3][4][5] or Dual-Discrete-Energy Gamma Radiography (DDEGR) [6], are used for the detection of concealed Special Nuclear Materials (SNM), providing high-resolution images of object shapes and densities and some selectivity between high-Z elements.DEBR makes use of continuous x-ray spectra, generated by accelerated electrons at two different bombarding energies. DDEGR relies on two discrete gamma-rays, of 4.4 MeV and 15.1 MeV, emitted by the 11 B(d,nγ) 12 C reaction. Fast-neutron imaging methods, such as Fast-Neutron Resonance Radiography (FNRR) [7], utilize a broad neutron spectrum of 2-10 MeV to provide a sensitive probe for identifying low-Z elements such as H, C, N and O; these are the main constituents of explosives and narcotics. In addition, FNRR provides a means for identifying the type of the explosive by determination of the density ratios of its main constituent elements [7]. FNRR has been also proposed recently for determining of oil and water content in drilled formation cores [8].The r...