Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

Rahman, Md. Ataur; Dash, Raju; Sohag, Abdullah Al Mamun; Alam, Mahboob; Rhim, Hyewhon; Ha, Hunjoo; Moon, Il Soo; Uddin, Jamal; Hannan, Md. Abdul

doi:10.3390/md19030167

Cited by 24 publications

(15 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effectiveness of all these molecules varies between patients and stages of the disease, and in many cases, these drugs have adverse effects (nausea, vomiting, and diarrhea). For all these reasons, numerous efforts have been made in developing new therapeutic agents to find new drugs of value against AD [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. It is widely known that the development of AD is linked to amyloid-β peptides and tau aggregation.…”

Section: Introductionmentioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

View full text Add to dashboard Cite

Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, they have structure and function similarities with biological sterols, especially cholesterol. Stigmasterol and β -sitosterol, specifically, have shown very promising results in clinical trials against several diseases [ 57 ]. Marine sterols may also provide prospective lead compounds in the development of new therapeutic drugs, due to recent advances in technology such as nanoparticles and microencapsulation [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Metabolites Profiling and In Vitro Biological Characterization of Different Fractions of Cliona sp. Marine Sponge from the Red Sea Egypt

et al. 2023

View full text Add to dashboard Cite

Red Sea marine sponges are an important source of biologically active natural products. Therefore, the present study aimed to investigate, for the first time, the components of n-hexane, dichloromethane, and ethyl acetate fractions of Cliona sp. marine sponge collected from the Red Sea, Egypt using UPLC-ESI-MS/MS (Ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry) analysis. The analysis revealed the tentative identification of 23, 16, and 24 compounds from the n-hexane, dichloromethane, and ethyl acetate fractions of Cliona sp., respectively. In addition, the examination of these fractions resulted in the isolation and identification of three sterols and one amino acid. The identification of the isolated compounds was confirmed by 1D and 2D NMR (Nuclear Magnetic Resonance), and MS (Mass spectrometry), and IR (Infrared) spectroscopy. The in vitro cytotoxic, antioxidant, and antimicrobial activities of the total ethanolic extract and its sub-fractions were also evaluated. Interestingly, the ethyl acetate fraction showed potent cytotoxic activity against colon (HCT-116) and human larynx carcinoma (HEP-2) cell lines with IC50 (Half-maximal Inhibitory Concentration) 6.11 ± 0.2 and 12.6 ± 0.9 µg/mL, respectively. However, the dichloromethane fraction showed strong antioxidant activity, with IC50 75.53 ± 3.41 µg/mL. Notably, the total ethanolic extract showed the strongest antibacterial activity against Staphylococcus aureus and Escherichia coli, with MIC (Minimum Inhibitory Concentration) 62.5 ± 0.82 and 125 ± 0.62 µg/mL, respectively, compared to other fractions. In conclusion, this is the first report on the secondary metabolites content and biological activities of Cliona sp. from the Red Sea, Egypt. It also highlights the need for further research on the most active fractions against various cancer cell lines and resistant bacterial and fungal strains. Cliona sp. extract and its fractions could be a potential source of novel and safe natural drugs with a wide range of medicinal and pharmaceutical applications.

show abstract

“…Additionally, terpenoids can decrease lipid peroxidation, preserving neuronal membrane integrity. Some terpenoids can inhibit the formation of amyloid plaques by binding to Aβ, thereby promoting the formation of nontoxic oligomers (Rahman et al, 2021). These cellular mechanisms collectively highlight terpenoids' potential as neuroprotective agents, offering avenues for therapeutic interventions in neurodegenerative disorders characterized by Aβ‐induced inflammation and oxidative stress.…”

Section: Intricate Interplaymentioning

confidence: 99%

Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases

Rani,

Zia‐Ul‐Sabah,

Tabassum

et al. 2024

Eur J of Neuroscience

View full text Add to dashboard Cite

Neurodegenerative diseases (NDs) are a significant global health concern, primarily affecting middle and older populations. Recently, there has been growing interest in herbal therapeutics as a potential approach to address diverse neuropathological conditions. Despite the widespread prevalence of NDs, limited phytochemical has been reported for their promising therapeutic potential with distinct underlying mechanisms. Additionally, the intricate molecular pathways influenced by herbal phytoconstituents, particularly in neurodegenerative disorders, are also not well documented. This report explores the phytoconstituents of Ficus racemosa (F. racemosa), an unfamiliar plant of the Moraceae family, for their potential interactions with pathological pathways of NDs. The influential phytoconstituents of F. racemosa, including polyphenols, glycosides, terpenoids, and furocoumarin, have been reported for targeting diverse pathological states. We proposed the most convincing molecular interplay between leading phytoconstituents and detrimental signalling cascades. However, extensive research is required to thoroughly understand the phytochemical persuaded intricate molecular pathway. The comprehensive evidence strongly suggests that F. racemosa and its natural compounds could be valuable in treating NDs. This points towards an exciting path for future research and the development of potential treatments based on a molecular level.

show abstract

Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

Cited by 24 publications

References 84 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Metabolites Profiling and In Vitro Biological Characterization of Different Fractions of Cliona sp. Marine Sponge from the Red Sea Egypt

Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases

Contact Info

Product

Resources

About