Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-Regeneration

Ashraf, Roqia; Sofi, Hasham S.; Beigh, Mushtaq A.; Majeed, Shafquat; Arjamand, Shabana; Sheikh, Faheem A.

doi:10.1007/978-981-13-0947-2_27

Cited by 23 publications

(10 citation statements)

References 179 publications

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“…SCs are the major glial cells of the PNS and have many roles, including maintenance of the nerve, myelination of the axons, and secretion of numerous molecules that promote axon growth and nerve regeneration, including neural cell adhesion molecules (N-CAM), collagen, laminin, and adhesion molecule L1 [3,60,63]. SCs at injury sites secrete trophic factors that control the regeneration process of axotomized neurons [64]. When transplanted into a peripheral nerve injury site, the SCs can migrate across the injury site to form a cellular bridge across which the regenerating axons can be guided (See Table 1 for some studies evaluate incorporation SCs with electrospun NGCs).…”

Section: Incorporated Cellsmentioning

confidence: 99%

Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

2022

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Injuries to the peripheral nervous system result in devastating consequences with loss of motor and sensory function and lifelong impairments. Current treatments have largely relied on surgical procedures, including nerve autografts to repair damaged nerves. Despite improvements to the surgical procedures over the years, the clinical success of nerve autografts is limited by fundamental issues, such as low functionality and mismatching between the damaged and donor nerves. While peripheral nerves can regenerate to some extent, the resultant outcomes are often disappointing, particularly for serious injuries, and the ongoing loss of function due to poor nerve regeneration is a serious public health problem worldwide. Thus, a successful therapeutic modality to bring functional recovery is urgently needed. With advances in three-dimensional cell culturing, nerve guidance conduits (NGCs) have emerged as a promising strategy for improving functional outcomes. Therefore, they offer a potential therapeutic alternative to nerve autografts. NGCs are tubular biostructures to bridge nerve injury sites via orienting axonal growth in an organized fashion as well as supplying a supportively appropriate microenvironment. Comprehensive NGC creation requires fundamental considerations of various aspects, including structure design, extracellular matrix components and cell composition. With these considerations, the production of an NGC that mimics the endogenous extracellular matrix structure can enhance neuron–NGC interactions and thereby promote regeneration and restoration of function in the target area. The use of electrospun fibrous substrates has a high potential to replicate the native extracellular matrix structure. With recent advances in electrospinning, it is now possible to generate numerous different biomimetic features within the NGCs. This review explores the use of electrospinning for the regeneration of the nervous system and discusses the main requirements, challenges and advances in developing and applying the electrospun NGC in the clinical practice of nerve injuries.

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Section: Incorporated Cellsmentioning

confidence: 99%

Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

2022

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“…ALG is a natural linear anionic polysaccharide, generally extracted from brown algae seaweed, consisting of repeated units of (1-4)-β-d-mannuronic acid and an α-l-guluronic acid building block [ 53 ]. ALG possesses several fruitful features, encompassing high biocompatibility, low toxicity, and good gelation properties, which make it an ideal polymer for the development of a scaffold intended for tissue engineering and drug delivery, due to its interaction with bivalent cations.…”

Section: Alginatementioning

confidence: 99%

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

et al. 2023

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Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised.

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“…Polymers are selected based on the end uses such as hydrogel applications, drug delivery vehicles, 3D cell culture, nerve conduits and tissue scaffolds. Successful polymers chosen for nerve conduit printing should offer mechanical support for growing neurites, reduce scar tissue formation, regulate cell healing signals to guide axonal growth and augment tissue regeneration and integration [ 47 , 48 ]. Polymeric neural probes and electrodes made with graphene nanoparticles are successfully implanted to treat peripheral nerve injury conditions and neurodegenerative diseases in animal models [ 49 , 50 , 51 , 52 ].…”

Section: Scaffold Materialsmentioning

confidence: 99%

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

Soman¹,

Vijayavenkataraman

2020

IJMS

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The peripheral nervous system controls the functions of sensation, movement and motor coordination of the body. Peripheral nerves can get damaged easily by trauma or neurodegenerative diseases. The injury can cause a devastating effect on the affected individual and his aides. Treatment modalities include anti-inflammatory medications, physiotherapy, surgery, nerve grafting and rehabilitation. 3D bioprinted peripheral nerve conduits serve as nerve grafts to fill the gaps of severed nerve bodies. The application of induced pluripotent stem cells, its derivatives and bioprinting are important techniques that come in handy while making living peripheral nerve conduits. The design of nerve conduits and bioprinting require comprehensive information on neural architecture, type of injury, neural supporting cells, scaffold materials to use, neural growth factors to add and to streamline the mechanical properties of the conduit. This paper gives a perspective on the factors to consider while bioprinting the peripheral nerve conduits.

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Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-Regeneration

Cited by 23 publications

References 179 publications

Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

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