Prospects of neuromodulation for chronic pain

Isagulyan, E D; Михайлова, В. А.; Aslakhanova, Karina S; Slavin, Konstantin V.

doi:10.1016/j.dscb.2021.100027

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Nowadays the field of neuromodulation is progressively evolving showing significant advancement in therapeutic efficacy. There is a growing number of new modes or targets of neurostimulation, continuous improvement in existing approaches, and steady reduction in complications [32].…”

Section: Stimulation Methodsmentioning

confidence: 99%

Spinal Cord Stimulation for Spinal Cord Injury

Isagulyan¹,

Михайлова²,

Ilyinski³

2023

Spinal Cord Injury - Current Trends in Acute Management, Function Preservation and Rehabilitation Protocols

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Spinal cord injury is a medically complex and life-disrupting condition, associated with very high mortality rates (early death rates after admission range from 4 to 20%). In addition, it’s complicated subsequent severe disability due to the development of early or late complications. Today, in high-income countries, SCI can be viewed less as the end of a worthwhile or productive life and more as a personal and social challenge that can be successfully overcome. SCI can be divided into two types of injury on the basis of severity: complete and incomplete injury. Damage to the spinal cord may be traumatic (falls, road traffic injuries, occupational and sports injuries, violence) or non-traumatic (infectious disease, tumor, musculoskeletal disease, congenital problems such as spina bifid).

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Section: Stimulation Methodsmentioning

confidence: 99%

Spinal Cord Stimulation for Spinal Cord Injury

Isagulyan¹,

Михайлова²,

Ilyinski³

2023

Spinal Cord Injury - Current Trends in Acute Management, Function Preservation and Rehabilitation Protocols

View full text Add to dashboard Cite

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The Role and Applications of Artificial Intelligence in the Treatment of Chronic Pain

Meier,

Refahi,

Hearne

et al. 2024

Curr Pain Headache Rep

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Wireless neuromodulation at submillimeter precision via a microwave split-ring resonator

Marar,

Jiang,

et al. 2024

Sci. Adv.

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A broad spectrum of electromagnetic waves has been explored for wireless neuromodulation. Transcranial magnetic stimulation, with long wavelengths, cannot provide submillimeter spatial resolution. Visible light, with its short wavelengths, suffers from strong scattering in the deep tissue. Microwaves have centimeter-scale penetration depth and have been shown to reversibly inhibit neuronal activity. Yet, microwaves alone do not provide sufficient spatial precision to modulate target neurons without affecting surrounding tissues. Here, we report a split-ring resonator (SRR) that generates an enhanced microwave field at its gap with submillimeter spatial precision. With the SRR, microwaves at dosages below the safe exposure limit are shown to inhibit the firing of neurons within 1 mm of the SRR gap site. The microwave SRR reduced seizure activity at a low dose in both in vitro and in vivo models of epilepsy. This microwave dosage is confirmed to be biosafe via histological and biochemical assessment of brain tissue.

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Prospects of neuromodulation for chronic pain

Cited by 3 publications

References 60 publications

Spinal Cord Stimulation for Spinal Cord Injury

Spinal Cord Stimulation for Spinal Cord Injury

The Role and Applications of Artificial Intelligence in the Treatment of Chronic Pain

Wireless neuromodulation at submillimeter precision via a microwave split-ring resonator

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