Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system

Laerm, A.; Helmbold, Peter; Goldberg, M.; Dammann, Reinhard; Holzhausen, Hans-Jürgen; Ballhausen, Wolfgang G.

doi:10.1016/j.jhep.2006.07.033

Cited by 48 publications

(49 citation statements)

References 24 publications

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“…Recent studies demonstrated that reduction of Prox1 was found in HCC tissues and low expression of Prox1 was associated with poor prognosis and un-differentiation status. 24,25 These data implicate a potential tumor suppressor role of Prox1 in HCC. However, the underlying mechanism by which Prox1 inhibits the development of HCC is unknown.…”

Section: Introductionmentioning

confidence: 71%

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype

Chang

Hung

2013

Cancer Biology & Therapy

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Section: Introductionmentioning

confidence: 71%

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype

Chang

Hung

2013

Cancer Biology & Therapy

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“…14,33,34 Decreased PROX1 expression has been found in several cancers, including hepatocellular carcinoma, biliary duct cancer, and breast cancer. [35][36][37] However, in colon cancer, overexpression of PROX1 induces colon cancer progression by promoting a transition from a benign to a highly dysplastic phenotype. 38 In cervical cancer, PROX1 lies within a region of amplification (chromosome 1q) which could suggest that PROX1 copy number gain may function similarly to that in colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Fluorescence in Situ Hybridization Markers for Prediction of Cervical Lymph Node Metastases

Wangsa

Heselmeyer‐Haddad

Ried

et al. 2009

The American Journal of Pathology

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The presence of lymph node metastases is associated with poor prognosis in early stage cervical cancer. As of yet, no molecular markers predicting lymph node metastases have been identified. We examined single genetic markers and a composite marker, comprised of three fluorescence in situ hybridization (FISH) probes targeting the genes LAMP3, PROX1, and PRKAA1, in pretreatment cervical biopsies from 16 lymph node positive cases and 15 lymph node negative controls from women with stage IB and IIA cervical cancer. In addition, we determined clonal patterns by including CCND1 to compare the clonal constitution of primary tumors and associated lymph node metastases. The composite FISH marker allowed for classification of patients into those with and without lymph node metastases with a sensitivity and specificity of 75% and 87%, respectively (P ‫؍‬ 0.001). The positive predictive value and negative predictive value were 86% and 76% , respectively. Clonal patterns varied among the tumors. In many cases , changes between the primary tumor and lymph node metastases in the most common clones may indicate that certain clones have a growth advantage for establishing metastases in lymph nodes. We conclude that the composite FISH marker may be useful for determining risk for subsequent development of lymph node metastases in patients with cervical cancer.

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“…Despite a high protein sequence similarity between Prospero and Prox1, the amino acid motif responsible for this asymmetric segregation of Prospero seems not present in Prox1 , and asymmetric segregation of Prox1 has not been reported to date. Like Prospero, Prox1 is also expressed in many other organs, such as the liver, brain, pancreas, heart, eye lens, ear sensory epithelium, taste bud, and retina (Oliver et al 1993;SosaPineda et al 2000;Govindarajan and Overbeek 2001;Miura et al 2003;Bermingham-McDonogh et al 2006;Dudas et al 2006;Edqvist et al 2006;Laerm et al 2007;Kirjavainen et al 2008;Risebro et al 2009). Interestingly, the cell-fate-specifying function of Prospero seems to have been inherited by Prox1 and appears to be the common functional theme of Prox1 in such diverse cell types.…”

Section: Prox1: the Master Regulator For Lymphatic Developmentmentioning

confidence: 99%

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

Choi

Lee²,

Hong

2012

Cold Spring Harbor Perspectives in Medicine

123

107

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The blood and lymphatic systems are the two major circulatory systems in our body. Although the blood system has been studied extensively, the lymphatic system has received much less scientific and medical attention because of its elusive morphology and mysterious pathophysiology. However, a series of landmark discoveries made in the past decade has begun to change the previous misconception of the lymphatic system to be secondary to the more essential blood vascular system. In this article, we review the current understanding of the development and pathology of the lymphatic system. We hope to convince readers that the lymphatic system is no less essential than the blood circulatory system for human health and well-being.

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Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system

Cited by 48 publications

References 24 publications

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype

Fluorescence in Situ Hybridization Markers for Prediction of Cervical Lymph Node Metastases

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

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