1995
DOI: 10.1016/0091-3057(95)00139-n
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Prostacyclin analogue TTC-909 reduces memory impairment in rats with cerebral embolism

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Cited by 14 publications
(4 citation statements)
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“…Additionally, administration of PGI 2 agonists TTC-909 [14] and ONO-1301 [15] both reduce infarct volume after middle cerebral artery occlusion (MCAO) in rats, with ONO-1301 reducing neurological deficits. TTC-909 was also shown to reduce memory impairments in rats with cerebral embolism [16], supporting the notion that PGI 2 may play a role in cognitive functions.…”
Section: Introductionmentioning
confidence: 75%
“…Additionally, administration of PGI 2 agonists TTC-909 [14] and ONO-1301 [15] both reduce infarct volume after middle cerebral artery occlusion (MCAO) in rats, with ONO-1301 reducing neurological deficits. TTC-909 was also shown to reduce memory impairments in rats with cerebral embolism [16], supporting the notion that PGI 2 may play a role in cognitive functions.…”
Section: Introductionmentioning
confidence: 75%
“…Researchers have observed that PGI 2 analogs provide neuronal protection and improve the outcome of learning and memory defects in the cerebral ischemia models of focal as well as global ischemia (Awad et al, 1983; Dohi, 1987; Karasawa et al, 2002, 2003; Takamatsu et al, 2002). In a gerbil global ischemia model and in a rat cerebral embolism ischemia model, it was shown that PGI 2 analogs reduced the neuronal loss in the hippocampal CA1 region and decreased memory impairments (Uchiyama-Tsuyuki et al, 1995; Matsuda et al, 1997; Cui et al, 1999; Satoh et al, 1999), further advocating the potential development of PGI 2 analogs for treating patients with ischemic injury, particularly delayed neuronal injury.…”
Section: Discussionmentioning
confidence: 99%
“…sodium protected against the development of stroke and renal damage, and resulted in blood pressure reduction and increased heart rate in saline-drinking, stroke-prone spontaneously hypertensive rats (SHRSPs) [29]. The PGI 2 analog TTC-909 reduced memory impairment in rats with cerebral embolism [30], and OP-2507 conferred protection against regional infarction and neurological deficits [31]. While a preliminary study suggested that PGI 2 lacked therapeutic efficacy in human cerebral infarction [32,33], these results did not exclude a beneficial role for PGI 2 in the treatment of acute cerebral ischemia, provided PGI 2 is administered at higher doses, for longer durations, and at earlier time points [15].…”
Section: Physiological Roles Of Pgimentioning
confidence: 99%